Natriuretic peptides B antibody

Principal name

Natriuretic peptides B antibody

Alternative names for Natriuretic peptides B antibody

NPPB, Brain natriuretic peptide, BNP, proBNP, Gamma-brain natriuretic peptide

SwissProt ID

P07634 (Pig), P13204 (Bovin), P13205 (Rat), P16859 (Canfa), P16860 (Human), P40753 (Mouse)

Gene ID

4879 (NPPB), 25105 (Nppb), 18158

Available reactivities

Hu (Human), Rt (Rat), Mky (Monkey), Ms (Mouse)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Radioimmunoassay (R), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), ELISA (capture) (E(capture)), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Natriuretic peptides B antibody

The family of natriuretic peptides comprise of several 22-53 amino acid peptides with vasoadilator and diuretic properties and play a pivotal role in cardiovascular homeostasis. The arterial natriuretic peptide (ANP) and the brain natriuretic peptide (BNP) are serected as prohormones (Pro-ANP and Pro-BNP and their levels are significantly increases in non survival cardiacdysfunction patients (1). They are also useful as a laboratory markers for myocardial dysfunction and various other clinical conditions such as pulmonary thromboembolism, transient tachypnea, sepsis and stroke. The levels of these peptides may also differentiate between survival and non-survival acute sepsis. The human BNP gene is located on chromosome 1 and encodes the prohormone proBNP. The main stimulus for peptide synthesis and secretion is myocyte stretch. The cardiac myocytesare the major sosurce of ProBNP, cardiac fibroblasts also produce the ProBNP. The realease of BNP is under the control of several neurohormone. The biological effects include diuresis, vasodilatation, inhibition of renin and aldosterone production and of cardiac and vascular myocyte growth (2)
There has been growing interest in the use of serum B-type natriuretic peptide (BNP) and the N-terminal segment of its pro-hormone (NT-proBNP) as biomarkers for cardiac disease. Increased plasma concentrations of cardiac-derived B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (proBNP) are both associated with left ventricular dysfunction (3). BNP protects the heart from adverse consequences of overload by increasing natriuresis and diuresis, relaxing vascular smooth muscle, inhibiting the renin-angiotensin-aldosterone system, and by counteracting cardiac hypertrophy and fibrosis. Human cardiomyocytes synthesized BNP as a 108 amino aicd prohormone (proBNP), which is cleaved to 32-amino aicd BNP and the 76-residue N-terminal fragment(NT-proBNP). Serum levels of both fragments are good indicator of cardiac dysfunction, increased concentrations are strong predictors of recurring myocardial infarction, heart failure, and even death.
The ProANP protein is a approximately 18kDa (151 amino acids) protein.

General readings

General / background references:Pfister R et al. Use of NT-proBNP in routine testing and comparison to BNP. Eur J Heart Fail 6:289-93 (2004). PubMed PMID: 14987578
Hall C Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail 6:257-60 (2004). PubMed PMID: 14987573
Hobbs FD et al. Reliability of N-terminal pro-brain natriuretic peptide assay in diagnosis of heart failure: cohort study in representative and high risk community populations. BMJ 324:1498 (2002). PubMed PMID: 12077039
Mair J et al. The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure. Clin Chem Lab Med 39:571-88 (2001). PubMed PMID: 11522102

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BNP Immune complex (BNP / proBNP / 24C5) antibody

BNP Immune complex Mouse IgG2a Ab-BNP2 Purified Hu E
1 mg / €590.00
  HyTest Ltd.

BNP Immune complex (BNP / proBNP / 24C5) antibody

BNP Immune complex Mouse IgG2a Ab-BNP2cc Purified Hu E, E(detection)
1 mg / €590.00
  HyTest Ltd.

Brain Natriuretic Peptide (BNP) antibody

Brain Natriuretic Peptide (BNP) Rabbit Purified Hu, Rt C, WB
50 µl / €530.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 7-13 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 7-13 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 17-16 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 17-16 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 21-46 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 21-46 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG2b 3-56 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG2b 3-56 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG2b 3-21 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG2b 3-21 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 50E1 Purified Hu E, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-10) antibody

Brain Natriuretic Peptide (BNP32) Rabbit Serum Hu R
0.1 ml / €440.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-10) antibody

Brain Natriuretic Peptide (BNP32) Rabbit Serum Hu R
20 µl / €170.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) antibody

Brain Natriuretic Peptide (BNP32) Rabbit Serum Hu, Rt C, E, R
0.1 ml / €480.00
  Acris Antibodies GmbH

Brain Natriuretic Peptide (BNP32) (1-32) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 2G9 Purified Hu E, WB
1 mg / €590.00
  HyTest Ltd.

Brain Natriuretic Peptide (BNP32) (11-17) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 24C5 Purified Hu E, E(detection), WB
1 mg / €590.00
  HyTest Ltd.

Brain Natriuretic Peptide (BNP32) (11-22) antibody

Brain Natriuretic Peptide (BNP32) Mouse IgG1 26E2 Purified Hu E, E(detection), WB
1 mg / €590.00
  HyTest Ltd.

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