NCBP2 antibody

Principal name

NCBP2 antibody

Alternative names for NCBP2 antibody

CBP20, PIG55, Nuclear cap-binding protein subunit 2

SwissProt ID

P52298 (Human), Q9CQ49 (Mouse)

Gene ID

22916 (NCBP2), 68092 (Ncbp2)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of NCBP2 antibody

In eukaryotes, the majority of mRNAs have an m(7)G cap, which is added cotranscriptionally and plays a critical role in many aspects of mRNA metabolism. The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC). CBC consists of two cap binding proteins, CBP20 and CBP80, which mediate the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation and U snRNA export. The genes CBC1 and CBC2 encode CBP80 and CBP20, respectively. CBP80 comprises three domains, each containing a MIF4G domain. CBP20 has an RNAP fold and associates with the second and third domains of CBP80. CBP also plays a role in nonsense-mediated decay (NMD), a process which eliminates mRNAs, and prematurely terminates translation. CBP80-bound mRNA undergoes a pioneer round of translation before CBP80-CBP20 are replaced by eIF4E, and Upf2 and Upf3 proteins.

General readings

Strasser A., et al.( (2005) EMBO J 24(13):2235-43.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NCBP2 antibody

  Rabbit polyclonal anti-NCBP2 antibody  
Western blot analysis of extracts from COLO205 cells, using NCBP2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NCBP2 antibody

Western blot (WB) analysis of CBP20 antibody (Cat.-No.: AP06704PU-N) at 1/500 dilution Lane1:Hela whole cell lysate Lane2:Mouse kidney tissue lysate Lane3:Rat liver tissue lysate Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NCBP2 antibody

Western blot analysis of extracts from COLO205 cells, using NCBP2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

NCBP2 antibody

Western blot analysis of extracts from COLO205 cells, using NCBP2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

NCBP2 - human gene knockout kit via CRISPR

NCBP2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NCBP2 - human gene knockout kit via CRISPR

NCBP2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NCBP2 - human gene knockout kit via CRISPR

NCBP2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NCBP2 - human gene knockout kit via CRISPR

NCBP2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ncbp2 - mouse gene knockout kit via CRISPR

Ncbp2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ncbp2 - mouse gene knockout kit via CRISPR

Ncbp2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ncbp2 - mouse gene knockout kit via CRISPR

Ncbp2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ncbp2 - mouse gene knockout kit via CRISPR

Ncbp2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NCBP2 (transcript variant 1)

  Recombinant protein of human nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 1  
NCBP2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

NCBP2 (transcript variant 2)

  Purified recombinant protein of Homo sapiens nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 2  
NCBP2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

NCBP2 (1-156, His-tag)

NCBP2 Human Purified > 95 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

NCBP2 (1-156, His-tag)

NCBP2 Human Purified > 95 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

NCBP2 overexpression lysate

NCBP2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NCBP2 (mGFP-tagged)-Human nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NCBP2 (mGFP-tagged)-Human nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, NCBP2 (Myc-DDK-tagged)-Human nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NCBP2 (Myc-DDK-tagged)-Human nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ncbp2 (GFP-tagged) - Mouse nuclear cap binding protein subunit 2 (Ncbp2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ncbp2 (GFP-tagged) - Mouse nuclear cap binding protein subunit 2 (Ncbp2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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