NCK2 antibody

Principal name

NCK2 antibody

Alternative names for NCK2 antibody

NCK adaptor protein 2, SH2/SH3 adaptor protein NCK-beta

SwissProt ID

O43639 (Human)

Gene ID

8440 (NCK2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP)

Background of NCK2 antibody

The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 (NCKα) and NCK2 (NCKβ), which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. Specifically, overexpression of NCK1 in NIH/3T3 cells decreases DNA synthesis stimulated by EGF. Furthermore, the SH2 domain of NCK2 inhibits EGF- and PDGF-induced DNA synthesis. The SH3 domain of NCK binds a proline-rich domain on PAK, a known actin cytoskeleton regulator. The NCK protein thus mediates the interaction between PAK and RAC. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation. Various growth factor receptors, cell surface antigens and adhesion molecules phosphorylate mammalian NCK1 and NCK2.The human NCK1 and NCK2 genes map to chromosomes 3q21 and 2q12, respectively.

General readings

Braverman L.E., et al. (1999) J. Biol. Chem. 274:5542-5549Latreille M., et al. (2006) J. Biol. Chem. 281:26633-26644

13 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NCK2 antibody

  Rabbit polyclonal anti-NCK2 antibody  
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using NCK2 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NCK2 antibody

Immunohistochemistry (IHC) analyzes of NCK2 antibody (Cat.-No.: AP06442PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms P
0.1 mg / €350.00
  Acris Antibodies GmbH

NCK2 (119-276) antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P
50 µg / €530.00
  Acris Antibodies GmbH

NCK2 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using NCK2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
50 µg / €230.00
  Assay Biotech

NCK2 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using NCK2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / €330.00
  Assay Biotech

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NCK2 (transcript variant 2)

  Recombinant protein of human NCK adaptor protein 2 (NCK2), transcript variant 2  
NCK2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

NCK2 (transcript variant 1)

  Recombinant protein of human NCK adaptor protein 2 (NCK2), transcript variant 1  
NCK2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

NCK2 (1-380, His-tag)

NCK2 Human Purified > 85 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

NCK2 (1-380, His-tag)

NCK2 Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

NCK2 overexpression lysate

NCK2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

NCK2 overexpression lysate

NCK2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NCK2 (mGFP-tagged) - Human NCK adaptor protein 2 (NCK2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NCK2 (mGFP-tagged) - Human NCK adaptor protein 2 (NCK2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NCK2 (Myc-DDK tagged) - Human NCK adaptor protein 2 (NCK2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, NCK2 (Myc-DDK tagged) - Human NCK adaptor protein 2 (NCK2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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