NDP antibody

Principal name

NDP antibody

Alternative names for NDP antibody

Norrin, Norrie disease protein,EVR2

SwissProt ID

P48744 (Mouse), Q00604 (Human), Q2KI78 (Bovin)

Gene ID

4693 (NDP), 17986 (Ndp)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of NDP antibody

Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.

General readings

Luhmann U F., et al. (2005) Invest Pothalmol Vis Sci. 46:3372-3382.Luhmann U F., et al. (2005) Genesis. 42:253-262

16 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NDP antibody

  Rabbit Polyclonal Norrin Antibody  
Western blot analysis of Norrin in Jurkat cell lysate with Norrin antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDP antibody

  Rabbit anti-NDP Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using NDP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDP antibody

  Rabbit polyclonal Anti-NDP Antibody  
WB Suggested Anti-NDP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

NDP - human gene knockout kit via CRISPR

NDP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NDP - human gene knockout kit via CRISPR

NDP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NDP - human gene knockout kit via CRISPR

NDP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NDP - human gene knockout kit via CRISPR

NDP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ndp - mouse gene knockout kit via CRISPR

Ndp - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ndp - mouse gene knockout kit via CRISPR

Ndp - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ndp - mouse gene knockout kit via CRISPR

Ndp - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ndp - mouse gene knockout kit via CRISPR

Ndp - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NDP (25-133, His-tag)

NDP Human Purified > 80 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

NDP (25-133, His-tag)

NDP Human Purified > 80 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

NDP overexpression lysate

NDP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ndp (GFP-tagged) - Mouse Norrie disease (pseudoglioma) (human) (Ndp), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ndp (GFP-tagged) - Mouse Norrie disease (pseudoglioma) (human) (Ndp), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ndp (Myc-DDK-tagged) - Mouse Norrie disease (pseudoglioma) (human) (Ndp), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ndp (Myc-DDK-tagged) - Mouse Norrie disease (pseudoglioma) (human) (Ndp), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

16 Item(s)

per page
  • LinkedIn