NDP kinase A antibody

Principal name

NDP kinase A antibody

Alternative names for NDP kinase A antibody

NME1, NDPKA, NM23, nm23-H1, GAAD, Nucleoside diphosphate kinase A, Granzyme A-activated DNase

SwissProt ID

P15531 (Human), P15532 (Mouse), Q05982 (Rat)

Gene ID

4830 (NME1), 191575 (Nme1), 8877 (SPHK1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Mky (Monkey)

Available hosts

Rabbit, Mouse, Chicken, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Frozen Sections (C), Dot blot (Dot), Flow Cytometry (F), Luminex (LMNX)

Background of NDP kinase A antibody

The NME1 gene was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. 
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. 
Cellular Location: Cytopla sm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. 
Tissue Location: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed.

General readings

Boissan, M. et al., Cancer Res. 70(19): 7710-7722 (2010).
Wang, P.H. et al., Gynecol. Oncol. 119(1): 70-75 (2010).
Conery, A.R. et al., Proc. Natl. Acad. Sci. U.S.A. 107(35): 15461-15466(2010).
Wang, Z. et al., Med. Sci. Monit. 16 (8): CR357-CR364 (2010).
Li, Y. et al., Cancer Res. 70(14): 5695-5705 (2010).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-NME1 mouse monoclonal antibody. (UM800022; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB91 Purified Can, Hu, Mky, Rt P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-NME1 mouse monoclonal antibody. (UM800023; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB92 Purified Can, Hu, Rt P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-NME1 mouse monoclonal antibody. (UM800024; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB93 Purified Can, Hu, Rt P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-NME1 mouse monoclonal antibody. (UM800025; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB94 Purified Can, Hu, Mky, Rt P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-NME1 mouse monoclonal antibody. (UM800022; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB91 Purified Can, Hu, Mky, Rt P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-NME1 mouse monoclonal antibody. (UM800023; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB92 Purified Can, Hu, Rt P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-NME1 mouse monoclonal antibody. (UM800024; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB93 Purified Can, Hu, Rt P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-NME1 mouse monoclonal antibody. (UM800025; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB94 Purified Can, Hu, Mky, Rt P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-NME1 Rabbit Polyclonal antibody. (TA590015) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDP kinase A antibody

NME1 ELISA with 1A12 Capture (TA600459) and 7F2 Detection (TA700460) Antibodies. Substrate used: Recombinant Human NME1 (TP301731) Mouse IgG1 OTI1A12 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDP kinase A antibody

NME1 ELISA with 4H2 Capture (TA600460) and 6E8 Detection (TA700461) Antibodies. Substrate used: Recombinant Human NME1 (TP301731) Mouse IgG1 OTI4H2 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDP kinase A antibody

NME1 ELISA with 22F10 Capture (TA600463) and 7D6 Detection (TA700459) Antibodies. Substrate used: Recombinant Human NME1 (TP301731) Mouse IgG1 OTI7D6 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801245) Mouse IgG2a OTI4G3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801246) Mouse IgG1 OTI2D8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801248) Mouse IgG2a OTI2A5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801249) Mouse IgG2a OTI7D6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801257) Mouse IgG1 OTI7E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801258) Mouse IgG2a OTI3F2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801259) Mouse IgG2a OTI1A12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NDP kinase A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NME1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801260) Mouse IgG1 OTI1C12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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