NDRG1 antibody

Principal name

NDRG1 antibody

Alternative names for NDRG1 antibody

CAP43, DRG1, DRG-1, RTP, Rit42, N-myc downstream-regulated gene 1 protein, Nickel-specific induction protein Cap43, Differentiation-related gene 1 protein, Reducing agents and tunicamycin-responsive protein

SwissProt ID

Q3SYX0 (Bovin), Q62433 (Mouse), Q6JE36 (Rat), Q92597 (Human)

Gene ID

10397 (NDRG1), 17988 (Ndrg1), 299923

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Rb (Rabbit), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of NDRG1 antibody

N-myc downstream-regulated gene 1 (NDRG1), also termed Cap43, Drg1, RTP/rit42, and Proxy-1, is a member of the NDRG family, which is composed of four members (NDRG1-4) that function in growth, differentiation, and cell survival. NDRG1 is ubiquitously expressed and highly responsive to a variety of stress sigls including D damage, hypoxia, and elevated levels of nickel and calcium. Expression of NDRG1 is elevated in N-myc defective mice and is negatively regulated by N- and c-myc. During D damage, NDRG1 is induced in a p53-dependent fashion and is necessary for p53-mediated apoptosis. Research studies have shown that NDRG1 may also play a role in cancer progression by promoting differentiation, inhibiting growth, and modulating metastasis and angiogenesis. Nonsense mutation of the NDRG1 gene has been shown to cause hereditary motor and sensory neuropathy-Lom (HMSNL), which is supported by studies demonstrating the role of NDRG1 in maintaining myelin sheaths and axol survival. NDRG1 is up-regulated during mast cell maturation and its deletion leads to attenuated allergic responses. Both NDRG1 and NDRG2 are substrates of SGK1, although the precise physiological role of SGK1-mediated phosphorylation is not known. NDRG1 is phosphorylated by SGK1 at Thr328, Ser330, Thr346, Thr356, and Thr366. Phosphorylation by SGK1 primes NDRG1 for phosphorylation by GSK-3.

General readings

Richardson DR., et al. (2008) Biochim Biophys Acta. 1783(10):1981-92.
Costa M., et al. (2008) Carcinogenesis. 29(1):2-8.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NDRG1 antibody

  Rabbit anti-NDRG1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using NDRG1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDRG1 (C-term) antibody

  Goat Polyclonal Antibody against NDRG1  
TA302840 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDRG1 antibody

  Anti-NDRG1 Rabbit Polyclonal Antibody  
Predicted band size: 43 kDa . Positive control: Human lymphoma tissue lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NDRG1 antibody

  Rabbit Polyclonal Anti-NDRG1 Antibody  
WB Suggested Anti-NDRG1 Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDRG1 antibody

  Rabbit Polyclonal Anti-NDRG1 Antibody  
WB Suggested Anti-NDRG1 Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NDRG1 (N-term) antibody

Western blot analysis of NDRG1 Antibody (N-term) (AP17582PU-N) in MDA-MB231 cell line lysates (35ug/lane). NDRG1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

NDRG1 (C-term) antibody

Immunohistochemistry Image: Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

NDRG1 antibody

NDRG1 Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NDRG1 - human gene knockout kit via CRISPR

NDRG1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NDRG1 - human gene knockout kit via CRISPR

NDRG1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NDRG1 - human gene knockout kit via CRISPR

NDRG1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ndrg1 - mouse gene knockout kit via CRISPR

Ndrg1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ndrg1 - mouse gene knockout kit via CRISPR

Ndrg1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ndrg1 - mouse gene knockout kit via CRISPR

Ndrg1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ndrg1 - mouse gene knockout kit via CRISPR

Ndrg1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NDRG1 (transcript variant 2)

  Recombinant protein of human N-myc downstream regulated 1 (NDRG1), transcript variant 2  
NDRG1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

NDRG1 (transcript variant 1)

  Recombinant protein of human N-myc downstream regulated 1 (NDRG1), transcript variant 1  
NDRG1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

NDRG1 (1-394, His-tag)

NDRG1 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

NDRG1 (1-394, His-tag)

NDRG1 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

NDRG1 overexpression lysate

NDRG1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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