NEMO / IKBKG antibody

Principal name

NEMO / IKBKG antibody

Alternative names for NEMO / IKBKG antibody

FIP3, FIP-3, IKKAP1, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modulator,NF-kappa-B essential modifier, Inhibitor of nuclear factor kappa-B kinase subunit gamma, IkB kinase-associated protein 1

SwissProt ID

O88522 (Mouse), Q6TMG5 (Rat), Q95KU9 (Bovin), Q9Y6K9 (Human)

Gene ID

8517 (IKBKG), 16151 (Ikbkg), 309295

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Bt (Bat), Eq (Equine), Hst (Hamster), Mky (Monkey), Prim (Primate), Shrew, Bear

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F)

Background of NEMO / IKBKG antibody

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization sigl of NF-kB thereby preventing translocation of NF-kB to the nucleus. Exterl stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kise complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. IKK3/g preferentially interacts with IKK2/b and is required for activation of IKK complex. IKK3/g is also known as NEMO (NF-kB Essential MOdulator). Recent data suggest that the human T-cell leukemia virus type I Tax oncoprotein that activates NF-kB binds neither to IKKa nor IKKb, but complexes directly with IKKg. This suggests that IKKg may be a key molecule acting as an adapter for onco-protein specific sigling to IKKa and IKKb.

General readings

1. Iha, H., et al. Oncogene, 22, 8912-8923 (2003).
2. Chu, Z.L., et al. J. Biol. Chem. 22, 15297-15300 (1999).
Clone EA2-6 is used in references number 1.)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NEMO / IKBKG antibody

Immunoperoxidase of monoclonal antibody to IKBKG on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Mouse IgG1 4G9 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

NEMO / IKBKG antibody

Western blot analysis of IKK gamma in HeLa whole cell lysate with IKK gamma antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of extracts from 293 cells, using IKK-? (Ab-31) AntibodyThe lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of extracts from COS-7 cells, using IKK-? antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of extracts from 293 cells treated with TNF-a (20ng /ml, 5mins), using IKK-? (Phospho-Ser31) Antibody (#TA311837).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of extracts from HepG2 cells, treated with Anisomycin (0.5uM, 5hours), using IKK-? (Phospho-Ser85) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using IKK-? (Phospho-Ser376) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of extracts from HepG2 cells, treated with Anisomycin (0.5uM, 5hours), using IKK-? (Ab-85) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of extracts from COLO cells, using OR10G6 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of IKK-gamma expression in 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of IKK-? expression in Anisomycin treated HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of IKK- gamma phosphorylation expression in TNF-a treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of IKK-? phosphorylation expression in Anisomycin treated HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western blot analysis of extracts of various cell lines, using IKBKG antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western Blot: IKK-gamma Antibody (46B844) [TA336392] - analysis using NEMO (IKKgamma) antibody. Lysate from human Jurkat cells probed with NEMO antibody at 2 ug/ml. I goat anti-mouse Ig HRP secondary and PicoTect ECL substrate solution were used for this Mouse IgG1 46B844 Purified Hu F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western Blot: IKK-gamma Antibody (72C627) [TA336398] - Analysis using IKK gamma (NEMO) antibody. Lysate from 1) human Jurkat and 2) mouse NIH 3T3 cells probed with IKK gamma antibody at 2 ug/ml. Mouse IgG1 72C627 Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western Blot: IKK-gamma Antibody [TA336681] - WB detection of IKK-gamma in Interleuking 1 stimulated 293 cells at 1:500 dilution. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Western Blot: IKK-gamma Antibody [TA336682] - WB detection of IKK-gamma in Interleukin 1 stimulated HEK 293 cells at a dilution of 1:500. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

NEMO / IKBKG Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NEMO / IKBKG antibody

Figure 1. Western blot using anti-IKKgamma Mab (Cat. #AM11080PU-N) to detect IKKgamma in ZR75-1 cell lysate. Mouse IgG1 55AT986.5.78 Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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