Nephrocystin 1 antibody

Principal name

Nephrocystin 1 antibody

Alternative names for Nephrocystin 1 antibody

NPHP1, NPH1

SwissProt ID

O15259 (Human), O15259-4, Q9QY53 (Mouse), Q9TU19 (Canfa)

Gene ID

4867 (NPHP1), 53885 (Nphp1)

Available reactivities

Ms (Mouse), Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Nephrocystin 1 antibody

Together with Cas NPHP1 may play a role in the control of epithelial cell polarity. NPHP1 seems to help to recruit protein tyrosine kise 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent sigling.This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion sigling, likely as part of a multifunctiol complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neotal breathing abnormalities, sometimes including retil dystrophy and rel disease. Multiple transcript variants encoding different isoforms have been found for this gene.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Nephrocystin 1 antibody

  Rabbit polyclonal Anti-NPHP1 Antibody  
WB Suggested Anti-NPHP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

Nephrocystin 1 antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Purified Ms WB
0.25 mg / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NPHP1 - human gene knockout kit via CRISPR

NPHP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NPHP1 - human gene knockout kit via CRISPR

NPHP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NPHP1 - human gene knockout kit via CRISPR

NPHP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NPHP1 - human gene knockout kit via CRISPR

NPHP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nphp1 - mouse gene knockout kit via CRISPR

Nphp1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nphp1 - mouse gene knockout kit via CRISPR

Nphp1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nphp1 - mouse gene knockout kit via CRISPR

Nphp1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nphp1 - mouse gene knockout kit via CRISPR

Nphp1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NPHP1 overexpression lysate

NPHP1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

NPHP1 overexpression lysate

NPHP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NPHP1 (mGFP-tagged) - Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (mGFP-tagged) - Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,620.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPHP1 (mGFP-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (mGFP-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPHP1 (mGFP-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (mGFP-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,620.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPHP1 (mGFP-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (mGFP-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,540.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPHP1 (mGFP-tagged) - Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (mGFP-tagged) - Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,270.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPHP1 (Myc-DDK tagged) - Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (Myc-DDK tagged) - Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,460.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPHP1 (Myc-DDK-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (Myc-DDK-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPHP1 (Myc-DDK-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NPHP1 (Myc-DDK-tagged)-Human nephronophthisis 1 (juvenile) (NPHP1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,460.00
  OriGene Technologies, Inc.

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