NESCA antibody

Principal name

NESCA antibody

Alternative names for NESCA antibody

RUSC1, RUN and SH3 domain-containing protein 1

SwissProt ID

Q8BG26 (Mouse), Q9BVN2 (Human)

Gene ID

23623 (RUSC1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of NESCA antibody

RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IkappaB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-kappaB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappaB activation pathway.

11 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NESCA antibody

Western blot analysis of RUSC1 in A-20 cell lysate with RUSC1 antibody at 1 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NESCA Control Peptide

NESCA
50 µg / €160.00
  Acris Antibodies GmbH

NESCA antibody

Immunofluorescence of purified MaxPab antibody to RUSC1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

NESCA antibody

Immunofluorescence of purified MaxPab antibody to RUSC1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

NESCA antibody

Immunohistochemistry-Paraffin: RUSC1 Antibody [NBP1-81004] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

NESCA antibody

Immunohistochemistry-Paraffin: RUSC1 Antibody [NBP1-81005] - Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

NESCA antibody

Immunohistochemistry-Paraffin: RUSC1 Antibody [NBP1-81006] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity(granular pattern) in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NESCA (transcript variant 4)

NESCA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

NESCA

NESCA Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

RUSC1 293T Cell Transient Overexpression Lysate(Denatured)

RUSC1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

RUSC1 overexpression lysate

RUSC1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

11 Item(s)

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