Netrin-1 antibody

Principal name

Netrin-1 antibody

Alternative names for Netrin-1 antibody

NTN1, NTN1L

SwissProt ID

O09118 (Mouse), O95631 (Human), Q924Z9 (Rat)

Gene ID

9423 (NTN1), 18208 (Ntn1), 114523

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Fe (Feline), Mky (Monkey), Rt (Rat), Macaque, Eq (Equine), Fi (Fish), Hst (Hamster), Op (Opossum), Por (Porcine), Prim (Primate), Xen (Xenopus), L (Lizard), Can (Canine), Chk (Chicken)

Available hosts

Chicken, Rabbit, Goat, Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Netrin-1 antibody

Netrin-1 (Ntrn1) also known as axonal guidance protein (Ntrn1) is a diffuse protein made by the floor plate cells that belongs to the netrin family of proteins. Netrin family of proteins guides axons to or away from the midline of the developing nervous system (1). In mammals, netrins act as ligands for DCC (deleted in colorectal cancer) receptor and the UNC5 receptor homologues: UNC5A, B, C and D. DCC mediates chemoattraction whereas repulsion is mediated by UNC5 homologues and, in some cases, DCC (2). Netrin-1, located at human chromosome 17p13-p12, attracts spinal commissural axons and repels trochlear axons in vitro. In mice, deficiencies in Netrin-1 led to defects in spinal commissural axon projections (3). Netrin-1 also acts as an early ventral spinal cord-derived chemorepellent for dorsal root ganglion (DRG) axons. In the dorsal and intermediate spinal cord, it prevents DRG axons from being directed towards the dorsal spinal cord (4). Netrin-1 and its associated receptors play a key role cell death and tumor formation.
Netrin-1/receptor pair induces apoptosis in cultured cells and also acts as regulators of tumor development (5, 6). These properties of Netrin-1 have been implicated in colorectal tumorigenesis by regulating apoptosis (6). In the embryo, Netrin-1 is widely expressed in the developing nervous system and in mesodermal tissues. In adults, it is highly expressed in heart, small intestine, colon, liver and prostrate. It is also expressed in brain tumors and neuroblastomas. Netrin-1 is approximately a 73kDa protein (604 amino acids).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Netrin-1 (C-term) antibody

TA305829 (0.5ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Netrin-1 antibody

NTN1 Antibody (C-term) (Cat. #TA325129) western blot analysis in U87-MG cell line lysates (35ug/lane).This demonstrates the NTN1 antibody detected the NTN1 protein (arrow). Rabbit IgG Purified Chk, Hu, Ms, Por WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Netrin-1 Control Peptide

Netrin-1 Purified
50 µg / €220.00
  Acris Antibodies GmbH

Netrin-1 antibody

Figure 1. Western blot using AP05263PU-N , Rabbit Polyclonal at 0.05 µg/ml on MDCKII cell extract (10 µg/lane). Blots were developed with goat anti rabbit Ig (1:75k) and Pierce's Supersignal West Femto system. Rabbit IgG Aff - Purified Bov, Fe, Hu, Mky, Ms, Rt WB
25 µg / €490.00
  Acris Antibodies GmbH

Netrin-1 antibody

Western blot using AP05263SU-N, rabbit polyclonal at 5 µg/ml on MDCKII cell extract (10 µg/lane). Blots were developed with goat anti rabbit Ig (1:100k) and Pierce's Supersignal West Femto system. Rabbit IgG Purified Bov, Fe, Hu, Mky, Ms, Rt WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Netrin-1 Control Peptide

Netrin-1
0.25 mg / €250.00
  Acris Antibodies GmbH

Netrin-1 antibody

Western blot using Netrin-1  antibody (AP10176PU-N at 1/500 dilution). Rabbit Aff - Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Netrin-1 antibody

Immunohistochemistry analysis of Netrin-1 antibody (Cat.-No AP20679PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Netrin-1 (498-509) antibody

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bov, Elephant, Eq, Fi, Hst, Hu, L, Mky, Ms, Op, Por, Prim, Rt, Xen P
50 µg / €470.00
  Acris Antibodies GmbH

Netrin-1 antibody

Dissociated cell cultures of an e13 Mouse brain showing Netrin-1 (green staining) in neuronal precursor cells. Chicken Ig Aff - Purified Hu, Ms ICC/IF, P
0.1 mg / €500.00
  Acris Antibodies GmbH

Netrin-1 antibody

Netrin-1 Mouse IgG2a 5H8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Netrin-1 antibody

Western blot using NTN1 polyclonal antibody ( Cat # PAB10137 ) at 5 µg/ml on MDCK II cell extract (10 µg/lane). Bov, Hu, Macaque, Ms, Rt
0.1 mg / €400.00
  Abnova Taiwan Corp.

Netrin-1 antibody

Netrin-1 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

Netrin-1 antibody

Immunohistochemical analysis of Netrin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Netrin-1 antibody

Immunohistochemical analysis of Netrin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Netrin-1 antibody

Immunohistochemical analysis of Netrin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Netrin-1 antibody

Dissociated cell cultures of an e13 mouse brain showing Netrin-1 (green staining) in neuronal precursor cells. Chicken Aff - Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €180.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Ntn1 - mouse gene knockout kit via CRISPR

Ntn1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ntn1 - mouse gene knockout kit via CRISPR

Ntn1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ntn1 - mouse gene knockout kit via CRISPR

Ntn1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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