Netrin receptor DCC antibody

Principal name

Netrin receptor DCC antibody

Alternative names for Netrin receptor DCC antibody

IGDCC1, Tumor suppressor protein DCC, Colorectal cancer suppressor, CRC18, CRCR1, Immunoglobulin superfamily DCC subclass member 1

SwissProt ID

P43146 (Human), P70211 (Mouse)

Gene ID

1630 (DCC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), Fi (Fish), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Xen (Xenopus), Bear, GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Netrin receptor DCC antibody

Deleted in Colorectal Carcinoma protein (DCC) is a transmembrane protein belonging to the immunoglobulin superfamily. DCC and neogenin are well-known as a receptor forNetrin 1 in developing brain, but DCC also acts as a gamma-secretase-dependent transcription coactivator. Therefore, DCC mediates axon guidance of neuronal growth cones towards sources of netrin-1 ligand. DCC is a tumor suppressor gene as well as a conditional oncogene (1). When DCC is bound to its ligand, Netrin, it acts as oncogene and activates the pathways that promote cell survival and neurite growth down-stream to ligand concentration. Halo DCC promotes apoptotic pathways (2,3). When DCC is not bound to netrin-1 it can initiate apoptosis without the formation of an apoptosome or cytochrome c release (4). Recently it was discovered that DCC suppresses metastasis in cells.

DCC is a 1447 aa protein resides on rat chromosome 18q12. DCC is expressed in low abundance ubiquitously and at higher levels in many areas of the brain, particularly in dopaminergic neurons. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Higher levels of DCC are found in neonatal tissues and its expression is significantly reduced in adult hood (3). The DCC is expressed on developing spinal cord neurons to promote axonal and neurite growth in response to netrin. DCC and neogenin, two of the netrin-1 receptors, have recently been shown to have sites for tyrosine phosphorylation (at Y1420 on DCC) and are likely interacting with Src family kinases in regulating responses to netrin-1(5). The DCC protein undergoes proteolytic degradation to yield a 120 kDa fragment in apoptotic cells (6).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Netrin receptor DCC antibody

  Rabbit polyclonal anti-DCC antibody  
Immunofluorescence analysis of LOVO cells, using DCC antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Netrin receptor DCC antibody

  Rabbit Polyclonal Anti-DCC Antibody  
WB Suggested Anti-DCC Antibody Titration: 0.2-1 ug/ml; Positive Control: ACHN cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Netrin receptor DCC antibody

  Rabbit Polyclonal Anti-DCC Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (DCC Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Netrin receptor DCC antibody

  DCC mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCC (RC218506, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DCC. Mouse IgG2b OTI4A1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Netrin receptor DCC antibody

  DCC mouse monoclonal antibody, clone OTI5D10 (formerly 5D10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCC (RC218506, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DCC. Mouse IgG1 OTI5D10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Netrin receptor DCC (1437-1447) antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bear, Can, Elephant, Eq, Fi, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Xen P
50 µg / €470.00
  Acris Antibodies GmbH

Netrin receptor DCC (Center) antibody

Formalin fixed and paraffin embedded human stomach tissue stained with Netrin receptor DCC Antibody Cat.-No AP51195PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Netrin receptor DCC antibody

Immunofluorescence analysis of LOVO cells, using DCC Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €230.00
  Assay Biotech

Netrin receptor DCC antibody

Immunofluorescence analysis of LOVO cells, using DCC Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

DCC - human gene knockout kit via CRISPR

DCC - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DCC - human gene knockout kit via CRISPR

DCC - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DCC - human gene knockout kit via CRISPR

DCC - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DCC - human gene knockout kit via CRISPR

DCC - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Netrin receptor DCC

  Recombinant protein of human deleted in colorectal carcinoma (DCC)  
Netrin receptor DCC Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DCC (mGFP-tagged) - Human deleted in colorectal carcinoma (DCC), 200 uL, >10^7 TU/mL

Lenti ORF particles, DCC (mGFP-tagged) - Human deleted in colorectal carcinoma (DCC), 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

15 Item(s)

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