Neuregulin 1 antibody

Principal name

Neuregulin 1 antibody

Alternative names for Neuregulin 1 antibody

NRG1, GGF, HGL, HRGA, NDF, SMDF, Heregulin, HRG, Breast cancer cell differentiation factor p45, Glial growth factor, Neu differentiation factor, Pro-neuregulin-1 membrane-bound isoform, Acetylcholine receptor-inducing activity, Sensory and motor neuron-derived factor

SwissProt ID

O93383 (Xenla), P43322 (Rat), Q02297 (Human), Q05199 (Chick), Q9UPE3 (Human)

Gene ID

3084 (NRG1), 112400 (Nrg1), 7183084 (accA)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Rb (Rabbit), Mky (Monkey), Eq (Equine), Por (Porcine), Sh (Sheep), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection))

Background of Neuregulin 1 antibody

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. [provided by RefSeq]. Transcript Variant: This variant (HRG-beta1), along with HRG-alpha, beta2, and beta3 variants, was identified in various normal tissues and cancer cell lines. The protein product encoded by this variant is distinct from that of HRG-alpha in the region of amino acids 213-239. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Choi W  et al. The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin. J Cell Sci 123:3102-11 (2010). IHC-Fr, WB ; Human . PubMed: 20736300

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neuregulin 1 antibody

Western blot analysis of extracts from SKOV3 cells, using NRG1 isoform-10 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

Western blot analysis of MCF7 cell lysate using NRG1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

To detect Human Heregulin-beta1 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Human Heregulin-beta1. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

To detect Human Heregulin-beta1 by sandwich ELISA (using 100ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human Heregulin-beta1(TA328336) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human Heregulin-beta1. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

Anti-NRG1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

Anti-NRG1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

NRG1 (neuregulin 1) Antibody (against the N terminal of NRG1) (50ug) validated by WB using Fetal Brain Lysate at 0.2-1 ug/ml. Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

NRG1 (neuregulin 1) Antibody (against the middle region of NRG1) (50ug) validated by WB using Jurkat cell lysate at 0.2-1 ug/ml. Rabbit IgG Purified Bov, GP, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

Western blot analysis on SK-OV3 cell lysate using NRG1 isoform-10 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuregulin 1 antibody

Transfected cell immunofluorescence: COS cells expressing Flag-tagged human Neureguline-HBD. Red = rabbit anti-Flag, Green = N120A/9. Mouse IgG2a N120A/9 Supernatant Hu ICC/IF
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Neuregulin 1 antibody

Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Myc-tagged Neuregulin-CRD (NRG-CRD) or untagged Kv2.1 plasmid and probed with N126B/31 (left), 19E10
(middle) and K89/41 (right) TC supe. Mouse IgG2b N126B/31 Supernatant Hu ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Neuregulin 1 antibody

Transfected cell immunofluorescence: COS cells expressing Flag-tagged human Neureguline-HBD. Red = rabbit anti-Flag, Green = N120A/9. Mouse IgG2a N120A/9 Purified Hu ICC/IF
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Neuregulin 1 antibody

Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Myc-tagged Neuregulin-CRD (NRG-CRD) or untagged Kv2.1 plasmid and probed with N126B/31 (left), 19E10
(middle) and K89/41 (right) TC supe. Mouse IgG2b N126B/31 Purified Hu ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Neuregulin 1 antibody

Figure 1. Immunohistochemical staining using HRG antibody (AM05303PU-N) on formalin fixed, paraffin embedded human prostate carcinoma tissue sections. Mouse IgG2a 7D5 Purified Hu, Ms, Rt C, IP, P, WB
0.1 mg / €570.00
  Acris Antibodies GmbH

Neuregulin 1 (Beta-3) antibody

Western Blot analysis: Cell lysates of 293T (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human NRG1 (1/1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 k1G13 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Neuregulin 1 (Beta-3) antibody

Western Blot analysis: Cell lysates of 293T (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human NRG1 (1/1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 k1G13 Purified Hu E, WB
50 µl / €230.00
  Acris Antibodies GmbH

Neuregulin 1 antibody

Immunohistochemistry (IHC) analysis of Neuregulin-1/SMDF antibody (Cat.-No.: AP06168PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Neuregulin 1 (Center) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Neuregulin 1 (Isoform 10) (N-term) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Neuregulin 1 antibody

Western Blot analysis of NRG1 expression in transfected 293T cell line (H00003084-T01) by NRG1 MaxPab polyclonal antibody.

Lane 1: NRG1 transfected lysate(32.67 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

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