Neurexin 1 alpha antibody

Principal name

Neurexin 1 alpha antibody

Alternative names for Neurexin 1 alpha antibody

NRXN1

SwissProt ID

Q28146 (Bovin), Q63372 (Rat), Q9CS84 (Mouse), Q9DDD0 (Chick), Q9UDM6 (Human), Q9ULB1 (Human)

Gene ID

9378 (NRXN1), 60391 (Nrxn1)

Available reactivities

Hu (Human), Bov (Bovine), Rt (Rat), Ms (Mouse), Can (Canine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Flow Cytometry (F)

Background of Neurexin 1 alpha antibody

Neurexins (NRXNs) are a family of transmembrane, syptic adhesion molecules. NRXNS were identified as receptors for a-latrotoxin, a presyptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presyptic proteins that form a trans-syptic cell-adhesion complex with postsyptic neuroligins. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer a-isoform (a-NRXNs) and a downstream promoter to generate a shorter �-isoform (�- NRXNs) .The a-isoforms and �-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presyptic membrane and bind trans-syptically to postsyptic adhesion molecules and receptors. Neurexins are expressed in all neurons, and are subject to extensive altertive splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns. The extracellular domain of neurexin 1a (NRXN1a) is composed of three neurexin repeats (I, II, and III), which each contains the modules LNS-EGF-LNS. NRXN1a binds endogenous ligands including neuroligins, LRRTM family members, neurexophilin, a-dystroglycan, and GABA(A) receptors. NRXN1a gene mutations have been identified in neuropsychiatric diseases including Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD).

General readings

Feng J, Schroer R, Yan J, Song W, Yang C, Bockholt A, Cook EH Jr, Skinner C, Schwartz CE, Sommer SS. High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci Lett. 2006 Nov 27;409(1):10-3. Epub 2006 Oct 10. PMID: 17034946

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neurexin 1 alpha antibody

HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human NRXN1 with DYKDDDDK tag probed with EB07831(0.5ug/ml) in Lane A and probed with anti- DYKDDDDK Tag (1/3000) in lane C. Mock-transfected HEK293 probed with EB07831(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neurexin 1 alpha antibody

Western blot analysis of Neurexin expression in tissue lysate from rat kidney (Lane 1) and rat liver (Lane 2). Rabbit Aff - Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neurexin 1 alpha antibody

Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates: 1,2. Anti-Neurexin 1α (extracellular) antibody , (1:400). 3,4. Anti-Neurexin 1α (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neurexin 1 alpha antibody

Neurexin 1 alpha Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Neurexin 1 alpha antibody

Neurexin 1 alpha Mouse IgG2b 4F7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neurexin 1 alpha antibody

NRXN1 polyclonal antibody ( Cat # PAB7583 ) ( 0.05 µg/ml ) staining of human brain ( cerebellum ) lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Neurexin 1 alpha antibody

Western blot analysis of extracts from Jurkat cells, using NRXN1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

Neurexin 1 alpha antibody

Western blot analysis of extracts from Jurkat cells, using NRXN1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Neurexin 1 alpha antibody

Neurexin 1 alpha Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Neurexin 1 alpha antibody

Neurexin 1 alpha Rabbit Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Nrxn1/ Nrxn2 / Nrxn3 antibody

Western blot analysis of Nrxn1/Nrxn2/Nrxn3 expression in tissue lysate from rat kidney ( Lane 1 ) and rat liver ( Lane 2 ) . Rabbit Bov, Hu, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neurexin 1 alpha (transcript variant alpha1)

Neurexin 1 alpha Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Neurexin 1 alpha

Neurexin 1 alpha Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Neurexin 1 alpha

Neurexin 1 alpha Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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