Neurochondrin antibody

Principal name

Neurochondrin antibody

Alternative names for Neurochondrin antibody

NCDN, KIAA0607

SwissProt ID

O35095 (Rat), Q2KJ97 (Bovin), Q9UBB6 (Human), Q9VI25 (Drome), Q9Z0E0 (Mouse)

Gene ID

89791 (Ncdn), 23154 (NCDN)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Frozen Sections (C)

Background of Neurochondrin antibody

Norbin, also known as Neurochondrin, is a neuron-specific cytoplasmic protein involved in dendrite outgrowth. Overexpression of norbin in cultured Neuro 2a cells induced neurite-outgrowth (1). Norbin is located at rat chromosome 5q36. In addition to its involvement in dendrite outgrowth, Norbin is implicated in neural plasticity, chondrocyte differentiation, and early embryogenesis and in bone metabolism by inducing bone marrow cells to absorb bone matrix (2). Norbin is also an important endogenous modulator of metabotropic glutamate receptor 5 (mGluR5). It increases the cell surface localization of the receptor and positively regulates its signaling by physically interacting with the receptor (3). Norbin also acts as a signal molecule. It is a negative regulator of Ca2+/Calmodulin-dependent protein kinase II (CaMKII) phosphorylation and it is essential for the spatial learning process of the neurons (4).
Recently it was shown that Norbin is a Diaphanous1 (Dia1) interacting protein, specifically binding to only the formin homology 3 (FH3). Furthermore, it was uncovered that the first 100 amino acids, but not the C-terminal region, of Norbin were responsible for its effect on neurite outgrowth (5). Norbin knockout mice showed a behavioral phenotype associated with a rodent model of schizophrenia and disruption of norbin gene resulted in epileptic seizure (3). Targeted disruption of Norbin gene resulted in embryonic lethality (6). It is also suggested that Norbin is involved in age and sex dependent brain function. Norbin is expressed in hippocampus, amygdala, septum, nucleus accumbens and dorsal striatum. It is approximately an 87.5kDa protein (729 amino acids).

General readings

Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, Fukamizu A. Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure. J Biol Chem. 2005 May 27;280(21):20503-8. Epub 2005 Mar 24. PMID: 15790563

18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neurochondrin antibody

WB Suggested Anti-NCDN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neurochondrin Control Peptide

Neurochondrin
0.25 mg / €250.00
  Acris Antibodies GmbH

Neurochondrin antibody

Western Blot of Norbin Antibody (Cat.-No AP09865PU-N) probed with Rat brain Lysate. Antibody dilution is 1/500 in antibody dilution buffer. MW of Norbin is 88.5kDa. Rabbit Aff - Purified Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Neurochondrin antibody

Neurochondrin Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Neurochondrin antibody

Neurochondrin Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Neurochondrin antibody

NCDN MaxPab polyclonal antibody. Western Blot analysis of NCDN expression in rat brain. Mouse Purified Hu, Rt E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Neurochondrin antibody

Neurochondrin Mouse IgG2a 1C7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neurochondrin antibody

Neurochondrin Goat Hu, Ms, Rt E
0.1 mg / €390.00
  Abnova Taiwan Corp.

Neurochondrin antibody

Human Brain; WB Suggested Anti-NCDN Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human brain; NCDN antibody - N-terminal region (ARP54995_P050) in Human Brain cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Neurochondrin antibody

Neurochondrin Goat IgG Aff - Purified E, WB
0.1 mg / €310.00
  Novus Biologicals Inc.

Neurochondrin antibody

Western Blot: neurochondrin Antibody [NBP1-55390] - This Anti-NCDN antibody was used in Western Blot of Fetal Brain tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Neurochondrin antibody

Immunohistochemistry-Paraffin: Neurochondrin Antibody [NBP1-87901] - Immunohistochemical staining of human cerebral cortex shows distinct cytoplasmic positivity in neurons. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neurochondrin

Neurochondrin Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Neurochondrin

Neurochondrin Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Neurochondrin

Neurochondrin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Neurochondrin

Neurochondrin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

NCDN 293T Cell Transient Overexpression Lysate(Denatured)

NCDN 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

NCDN overexpression lysate

NCDN overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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