Neurochondrin antibody

Principal name

Neurochondrin antibody

Alternative names for Neurochondrin antibody

NCDN, KIAA0607

SwissProt ID

O35095 (Rat), Q2KJ97 (Bovin), Q9UBB6 (Human), Q9VI25 (Drome), Q9Z0E0 (Mouse)

Gene ID

23154 (NCDN), 89791 (Ncdn)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of Neurochondrin antibody

Norbin, also known as Neurochondrin, is a neuron-specific cytoplasmic protein involved in dendrite outgrowth. Overexpression of norbin in cultured Neuro 2a cells induced neurite-outgrowth (1). Norbin is located at rat chromosome 5q36. In addition to its involvement in dendrite outgrowth, Norbin is implicated in neural plasticity, chondrocyte differentiation, and early embryogenesis and in bone metabolism by inducing bone marrow cells to absorb bone matrix (2). Norbin is also an important endogenous modulator of metabotropic glutamate receptor 5 (mGluR5). It increases the cell surface localization of the receptor and positively regulates its signaling by physically interacting with the receptor (3). Norbin also acts as a signal molecule. It is a negative regulator of Ca2+/Calmodulin-dependent protein kinase II (CaMKII) phosphorylation and it is essential for the spatial learning process of the neurons (4).
Recently it was shown that Norbin is a Diaphanous1 (Dia1) interacting protein, specifically binding to only the formin homology 3 (FH3). Furthermore, it was uncovered that the first 100 amino acids, but not the C-terminal region, of Norbin were responsible for its effect on neurite outgrowth (5). Norbin knockout mice showed a behavioral phenotype associated with a rodent model of schizophrenia and disruption of norbin gene resulted in epileptic seizure (3). Targeted disruption of Norbin gene resulted in embryonic lethality (6). It is also suggested that Norbin is involved in age and sex dependent brain function. Norbin is expressed in hippocampus, amygdala, septum, nucleus accumbens and dorsal striatum. It is approximately an 87.5kDa protein (729 amino acids).

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neurochondrin antibody

  Rabbit Polyclonal Anti-NCDN Antibody  
WB Suggested Anti-NCDN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neurochondrin antibody

Neurochondrin Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NCDN - human gene knockout kit via CRISPR

NCDN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NCDN - human gene knockout kit via CRISPR

NCDN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NCDN - human gene knockout kit via CRISPR

NCDN - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NCDN - human gene knockout kit via CRISPR

NCDN - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NCDN overexpression lysate

NCDN overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NCDN (mGFP-tagged) - Human neurochondrin (NCDN), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, NCDN (mGFP-tagged) - Human neurochondrin (NCDN), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NCDN (mGFP-tagged)-Human neurochondrin (NCDN), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NCDN (mGFP-tagged)-Human neurochondrin (NCDN), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NCDN (Myc-DDK tagged) - Human neurochondrin (NCDN), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, NCDN (Myc-DDK tagged) - Human neurochondrin (NCDN), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, NCDN (Myc-DDK-tagged)-Human neurochondrin (NCDN), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NCDN (Myc-DDK-tagged)-Human neurochondrin (NCDN), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ncdn (GFP-tagged ORF) - Rat neurochondrin (Ncdn), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ncdn (GFP-tagged ORF) - Rat neurochondrin (Ncdn), 200 uL, >10^7 TU/mL  
200 µl / €1,420.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ncdn (Myc-DDK-tagged ORF) - Rat neurochondrin (Ncdn), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ncdn (Myc-DDK-tagged ORF) - Rat neurochondrin (Ncdn), 200 uL, >10^7 TU/mL  
200 µl / €1,276.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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