NEUROD1 antibody

Principal name

NEUROD1 antibody

Alternative names for NEUROD1 antibody

NEUROD1, NEUROD, Neurogenic differentiation factor 1

SwissProt ID

P79765 (Chick), Q13562 (Human), Q60867 (Mouse), Q64289 (Rat)

Gene ID

4760 (NEUROD1), 18012 (Neurod1), 29458

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Eq (Equine), Por (Porcine), Sh (Sheep)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of NEUROD1 antibody

The NEUROD1 gene encodes a member of the NeuroD family of basic-loop-helix transcription factors.  The NEUROD 1 was first described by Lee et al (1995) who observed that the gene was transiently expressed in subsets of neuronal cells of the central and peripheral nervous system at the time of their terminal differentiation into mature neurons. They also showed that ectopic expression of the NEUROD1 gene could convert non-neuronal cells to neuronal cells. The NEUROD1 protein forms heterodimers with other bHLH proteins and activates the transcription of a large set of genes that contain the E-box DNA sequence 5’-CANNTG’-3.  NEUROD1 is involved in the regulation of several cell differentiation pathways including the development of retinal ganglion cell, inner ear sensory neurons, and endocrine islet cells. NeuroD1 regulates the expression of numerous genes including the insulin gene. Mutations in the NEUROD1 gene has been associated with type II diabetes mellitus. Defects in expression of  NEUROD1 is linked with Maturity onset diabetes of the young type 6 (MODY6).  The NEUROD1 protein may be localized in the cytoplasm and the nucleus.  In Min 6 insulinoma cells Petersen et al (2002) were able to conclude that MEK-ERK associated phosphorylation of the serine 274 on NEUROD1 induces the translocation of the protein to the nucleus and that this may normally be associated with cell glucose concentration.

General readings

Peng,S.Y., et al., (2005) Biochim. Biophys. Acta 1731 (3), 154-159

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CRISPR

Catalog No. Species Donor Vector  

Neurod1 - mouse gene knockout kit via CRISPR

Neurod1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Neurod1 - mouse gene knockout kit via CRISPR

Neurod1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NEUROD1

  Recombinant protein of human neurogenic differentiation 1 (NEUROD1)  
NEUROD1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NEUROD1 overexpression lysate

NEUROD1 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NEUROD1 (mGFP-tagged) - Human neurogenic differentiation 1 (NEUROD1), 200 uL, >10^7 TU/mL

Lenti ORF particles, NEUROD1 (mGFP-tagged) - Human neurogenic differentiation 1 (NEUROD1), 200 uL, >10^7 TU/mL  
200 µl / €1,082.00
  OriGene Technologies, Inc.

Lenti ORF particles, NEUROD1 (Myc-DDK tagged) - Human neurogenic differentiation 1 (NEUROD1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, NEUROD1 (Myc-DDK tagged) - Human neurogenic differentiation 1 (NEUROD1) , 200 uL, >10^7 TU/mL  
200 µl / €969.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Neurod1 (GFP-tagged) - Mouse neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Neurod1 (GFP-tagged) - Mouse neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Neurod1 (Myc-DDK-tagged) - Mouse neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Neurod1 (Myc-DDK-tagged) - Mouse neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Neurod1 (GFP-tagged ORF) - Rat neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Neurod1 (GFP-tagged ORF) - Rat neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Neurod1 (Myc-DDK-tagged ORF) - Rat neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Neurod1 (Myc-DDK-tagged ORF) - Rat neurogenic differentiation 1 (Neurod1), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

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