NEUROD1 antibody

Principal name

NEUROD1 antibody

Alternative names for NEUROD1 antibody

NEUROD1, NEUROD, Neurogenic differentiation factor 1

SwissProt ID

P79765 (Chick), Q13562 (Human), Q60867 (Mouse), Q64289 (Rat)

Gene ID

4760 (NEUROD1), 18012 (Neurod1), 29458

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Eq (Equine), Por (Porcine), Sh (Sheep)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of NEUROD1 antibody

The NEUROD1 gene encodes a member of the NeuroD family of basic-loop-helix transcription factors.  The NEUROD 1 was first described by Lee et al (1995) who observed that the gene was transiently expressed in subsets of neuronal cells of the central and peripheral nervous system at the time of their terminal differentiation into mature neurons. They also showed that ectopic expression of the NEUROD1 gene could convert non-neuronal cells to neuronal cells. The NEUROD1 protein forms heterodimers with other bHLH proteins and activates the transcription of a large set of genes that contain the E-box DNA sequence 5’-CANNTG’-3.  NEUROD1 is involved in the regulation of several cell differentiation pathways including the development of retinal ganglion cell, inner ear sensory neurons, and endocrine islet cells. NeuroD1 regulates the expression of numerous genes including the insulin gene. Mutations in the NEUROD1 gene has been associated with type II diabetes mellitus. Defects in expression of  NEUROD1 is linked with Maturity onset diabetes of the young type 6 (MODY6).  The NEUROD1 protein may be localized in the cytoplasm and the nucleus.  In Min 6 insulinoma cells Petersen et al (2002) were able to conclude that MEK-ERK associated phosphorylation of the serine 274 on NEUROD1 induces the translocation of the protein to the nucleus and that this may normally be associated with cell glucose concentration.

General readings

Peng,S.Y., et al., (2005) Biochim. Biophys. Acta 1731 (3), 154-159

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NEUROD1 (N-term) antibody

  Rabbit polyclonal NeuroD1 Antibody (N-term)  
Western blot analysis of hNeuroD1-Q30 (Cat. #TA324696) in HepG2 cell line lysates (35ug/lane). NEUROD1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu P
0.4 ml / €410.00
  OriGene Technologies, Inc.

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