Neuromedin B receptor antibody

Principal name

Neuromedin B receptor antibody

Alternative names for Neuromedin B receptor antibody

NMB-R, NMBR

SwissProt ID

O54799 (Mouse), P24053 (Rat), P28336 (Human)

Gene ID

4829 (NMBR), 18101 (Nmbr), 25264

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Neuromedin B receptor antibody

Bombesin receptor 1 (BB1) is a member of a family of receptors that binds the 14 amino acid peptide bombesin. Bombesin was initially isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP) and neuromedin B (NMB), 27 and 10 amino acid homologues, respectively. BB1 is the preferred receptor for NMB (therefore it is also known as NMB receptor) while BB2 is the preferred receptor for GRP. BB3 was the third member of the bombesin family of receptors to be cloned based upon its sequence similarity to BB1 and BB2. The affinity of BB3 for bombesin is lower than that of the BB1 and BB2 receptors, as are its affinities for NMB and GRP. This suggests that the endogenous mammalian ligand for the BB3 receptor remains to be identified. All three bombesin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB1 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth. BB1 is expressed in the brain where it likely mediates the inhibition of food intake and regulates the stress and fear response. BB1 and its ligand NMB are expressed in the pituitary where they participate in the regulation of thyroid-stimulating hormone (TSH) secretion in both autocrine and paracrine fashions.In the periphery, BB1 is expressed in the gastrointestil and urogenital smooth muscle but its physiological function in these tissues is unclear. Filly, BB1 is over-expressed in several human tumors especially colon and non-small lung cancer where it acts as a growth factor receptor inducing tumor growth. BB1 is considered a potential target for the development of both diagnostics and anti-cancer therapies.

General readings

Luttrell, L.M. Mol. Biotechnol. 39(3): 239-264 (2008)
Dowal, L. et al., J. Biol. Chem. 281(33): 23999-24014 (2006)
Matusiak, D. et al., Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718-G728 (2005)
Lee, S. et al., FEBS Lett. 460(2): 263-269 (1999)
Sainz, E. et al., J. Biol. Chem. 273(26): 15927-15932 (1998)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neuromedin B receptor antibody

  Rabbit Polyclonal Anti-Bombesin Receptor 1  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-Bombesin Receptor 1 antibody, (1:1000). 3, 4. Anti-Bombesin Receptor 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neuromedin B receptor (Cytopl. Dom) antibody

  Rabbit Polyclonal Anti-NMBR Antibody (Cytoplasmic Domain)  
Anti-NMBR antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 16 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Neuromedin B receptor antibody

  Rabbit Polyclonal Anti-NMBR Antibody (C-Terminus)  
Anti-NMBR antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Neuromedin B receptor antibody

  Rabbit polyclonal anti-NMBR antibody  
Western blot analysis of extracts from 293 cells and Jurkat cells, using NMBR antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neuromedin B receptor antibody

  Rabbit Polyclonal Anti-NMBR Antibody - N-terminal region  
WB Suggested Anti-NMBR Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuromedin B receptor antibody

Western blot analysis with extracts from 293 cells using Neuromedin B receptor antibody (Cat.-No.  AP01274PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Neuromedin B receptor (N-term) antibody

Western blot analysis in MCF-7 cell line lysates (35ug/lane) using Neuromedin B receptor antibody Cat.-No. AP52896PU-N (N-term). This demonstrates this antibody detected the Neuromedin B receptor (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Neuromedin B receptor antibody

Immunofluorescence analysis of A549 cells, using NMBR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

Neuromedin B receptor antibody

Immunofluorescence analysis of A549 cells, using NMBR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

NMBR - human gene knockout kit via CRISPR

NMBR - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NMBR - human gene knockout kit via CRISPR

NMBR - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NMBR - human gene knockout kit via CRISPR

NMBR - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NMBR - human gene knockout kit via CRISPR

NMBR - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nmbr - mouse gene knockout kit via CRISPR

Nmbr - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nmbr - mouse gene knockout kit via CRISPR

Nmbr - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nmbr - mouse gene knockout kit via CRISPR

Nmbr - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nmbr - mouse gene knockout kit via CRISPR

Nmbr - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NMBR overexpression lysate

NMBR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NMBR (mGFP-tagged) - Human neuromedin B receptor (NMBR), 200 uL, >10^7 TU/mL

Lenti ORF particles, NMBR (mGFP-tagged) - Human neuromedin B receptor (NMBR), 200 uL, >10^7 TU/mL  
200 µl / €970.00
  OriGene Technologies, Inc.

Lenti ORF particles, NMBR (Myc-DDK tagged) - Human neuromedin B receptor (NMBR) , 200 uL, >10^7 TU/mL

Lenti ORF particles, NMBR (Myc-DDK tagged) - Human neuromedin B receptor (NMBR) , 200 uL, >10^7 TU/mL  
200 µl / €870.00
  OriGene Technologies, Inc.

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