Neuronal acetylcholine receptor subunit alpha-2 antibody

Principal name

Neuronal acetylcholine receptor subunit alpha-2 antibody

Alternative names for Neuronal acetylcholine receptor subunit alpha-2 antibody

CHRNA2, Nicotinic acetylcholine receptor subunit alpha 2

SwissProt ID

P12389 (Rat), Q15822 (Human), Q91X60 (Mouse)

Gene ID

1135 (CHRNA2), 170945 (Chrna2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of Neuronal acetylcholine receptor subunit alpha-2 antibody

Nicotinic Acetylcholine Receptors (ChRs) mediate the physiological effects of exogenous nicotine. They also play critical physiological roles throughout the brain and body by mediating cholinergic excitatory neurotransmission, modulating the release of neurotransmitters, and have longer-term effects on gene expression and cellular connections.ChRs are pentameric complexes made up of combitions of a number of different ChR subunits, which can be classified as a subunits, containing two cysteine residues at positions alogous to Cys192 and Cys193, and non-alpha subunits (â??structuralâ?? subunits), which can be defined as Ã? subunits when they are expressed in the vertebrate nervous system. There are nine a subunits (a2â??a10) and three Ã? subunits (Ã?2, Ã?3, and Ã?4) in the CNS. Nicotinic receptors are assembled as combitions of a (2-6) and and Ã? (2-4) subunits. All a subunits are expressed in neurol cells except for the a1 subunit which is specifically expressed in skeletal muscle. They are also expressed in non-neurol cells such as bronchial epithelial cells, as well lymphocytes.In humans, a mutant a2 subunit has been identified, which forms ChRs with increased agonist sensitivity and causes a form of familial epilepsy6. Further, an a2 subunit mouse model has been used to demonstrate a role for a2 ChR in nicotine-induced modulation of long-term potentiation in the mouse hippocampal CA1 region, which may underlie some of the cognitive effects of nicotine.

General readings

Elliott, K. J., et al., (1996) J. Mol. Neurosci. 7:217-228

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neuronal acetylcholine receptor subunit alpha-2 antibody

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain membranes: 1-2. Anti-Nicotinic Acetylcholine Receptor a2(extracellular) antibody, (1:400). 3-4. Anti-Nicotinic Acetylcholine Receptor a2(extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit alpha-2 antibody

Host: Rabbit; Target Name: CHRNA2 Lane A: HepG2 cell lysates Lane B: Raji cell lysates; Antibody Dilution: 0.5ug/ml Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit alpha-2 (N-term) antibody

CHRNA2 Antibody (N-term) (Cat. #AP50908PU-N) western blot analysis in Jurkat cell line lysates (35µg/lane).This demonstrates the CHRNA2 antibody detected the CHRNA2 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Neuronal acetylcholine receptor subunit alpha-2 antibody

Neuronal acetylcholine receptor subunit alpha-2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Neuronal acetylcholine receptor subunit alpha-2 antibody

HepG2, Raji; Host:. Rabbit. Target Name:. CHRNA2Lane A: HepG2 cell lysatesLane B: Raji cell lysates. Antibody Dilution: 0.5ug/ml; CHRNA2 antibody - N-terminal region (AVARP13064_T100) in HepG2, Raji cells using Western Blot Rabbit Aff - Purified Hu
0.1 mg / €310.00
  AVIVA Systems Biology

Neuronal acetylcholine receptor subunit alpha-2 antibody

Neuronal acetylcholine receptor subunit alpha-2 Rabbit Aff - Purified Hu WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neuronal acetylcholine receptor subunit alpha-2

Neuronal acetylcholine receptor subunit alpha-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit alpha-2

Neuronal acetylcholine receptor subunit alpha-2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Neuronal acetylcholine receptor subunit alpha-2

Neuronal acetylcholine receptor subunit alpha-2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CHRNA2 overexpression lysate

CHRNA2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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