Neuronal acetylcholine receptor subunit alpha-2 antibody

Principal name

Neuronal acetylcholine receptor subunit alpha-2 antibody

Alternative names for Neuronal acetylcholine receptor subunit alpha-2 antibody

CHRNA2, Nicotinic acetylcholine receptor subunit alpha 2

SwissProt ID

P12389 (Rat), Q15822 (Human), Q91X60 (Mouse)

Gene ID

1135 (CHRNA2), 170945 (Chrna2), 110902

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of Neuronal acetylcholine receptor subunit alpha-2 antibody

Nicotinic Acetylcholine Receptors (ChRs) mediate the physiological effects of exogenous nicotine. They also play critical physiological roles throughout the brain and body by mediating cholinergic excitatory neurotransmission, modulating the release of neurotransmitters, and have longer-term effects on gene expression and cellular connections.ChRs are pentameric complexes made up of combitions of a number of different ChR subunits, which can be classified as a subunits, containing two cysteine residues at positions alogous to Cys192 and Cys193, and non-alpha subunits (â??structuralâ?? subunits), which can be defined as Ã? subunits when they are expressed in the vertebrate nervous system. There are nine a subunits (a2â??a10) and three Ã? subunits (Ã?2, Ã?3, and Ã?4) in the CNS. Nicotinic receptors are assembled as combitions of a (2-6) and and Ã? (2-4) subunits. All a subunits are expressed in neurol cells except for the a1 subunit which is specifically expressed in skeletal muscle. They are also expressed in non-neurol cells such as bronchial epithelial cells, as well lymphocytes.In humans, a mutant a2 subunit has been identified, which forms ChRs with increased agonist sensitivity and causes a form of familial epilepsy6. Further, an a2 subunit mouse model has been used to demonstrate a role for a2 ChR in nicotine-induced modulation of long-term potentiation in the mouse hippocampal CA1 region, which may underlie some of the cognitive effects of nicotine.

General readings

Elliott, K. J., et al., (1996) J. Mol. Neurosci. 7:217-228

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neuronal acetylcholine receptor subunit alpha-2 antibody

  Rabbit Polyclonal Anti-Nicotinic Acetylcholine Receptor Alpha2 (extracellular)  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain membranes: 1-2. Anti-Nicotinic Acetylcholine Receptor a2(extracellular) antibody, (1:400). 3-4. Anti-Nicotinic Acetylcholine Receptor a2(extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit alpha-2 antibody

  Rabbit Polyclonal Anti-CHRNA2 Antibody  
Host: Rabbit; Target Name: CHRNA2 Lane A: HepG2 cell lysates Lane B: Raji cell lysates; Antibody Dilution: 0.5ug/ml Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit alpha-2 (N-term) antibody

CHRNA2 Antibody (N-term) (Cat. #AP50908PU-N) western blot analysis in Jurkat cell line lysates (35µg/lane).This demonstrates the CHRNA2 antibody detected the CHRNA2 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CHRNA2 - human gene knockout kit via CRISPR

CHRNA2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CHRNA2 - human gene knockout kit via CRISPR

CHRNA2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CHRNA2 - human gene knockout kit via CRISPR

CHRNA2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CHRNA2 - human gene knockout kit via CRISPR

CHRNA2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Chrna2 - mouse gene knockout kit via CRISPR

Chrna2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Chrna2 - mouse gene knockout kit via CRISPR

Chrna2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Chrna2 - mouse gene knockout kit via CRISPR

Chrna2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Chrna2 - mouse gene knockout kit via CRISPR

Chrna2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neuronal acetylcholine receptor subunit alpha-2

  Recombinant protein of human cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2)  
Neuronal acetylcholine receptor subunit alpha-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CHRNA2 overexpression lysate

CHRNA2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CHRNA2 (mGFP-tagged) - Human cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), 200 uL, >10^7 TU/mL

Lenti ORF particles, CHRNA2 (mGFP-tagged) - Human cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CHRNA2 (Myc-DDK tagged) - Human cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CHRNA2 (Myc-DDK tagged) - Human cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Chrna2 (GFP-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna2 (GFP-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, Chrna2 (Myc-DDK-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna2 (Myc-DDK-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Chrna2 (GFP-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna2 (GFP-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL  
200 µl / €1,130.00
  OriGene Technologies, Inc.

Lenti ORF particles, Chrna2 (Myc-DDK-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna2 (Myc-DDK-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 2 (neuronal) (Chrna2), 200 uL, >10^7 TU/mL  
200 µl / €1,014.00
  OriGene Technologies, Inc.

19 Item(s)

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