Neuronal acetylcholine receptor subunit alpha-6 antibody

Principal name

Neuronal acetylcholine receptor subunit alpha-6 antibody

Alternative names for Neuronal acetylcholine receptor subunit alpha-6 antibody

Nicotinic acetylcholine receptor subunit alpha-6, CHRNA6

SwissProt ID

P43143 (Rat), P49581 (Chick), Q15825 (Human), Q9R0W9 (Mouse)

Gene ID

8973 (CHRNA6), 81721 (Chrna6), 11440

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Av (Birds), Bov (Bovine), Eq (Equine), Fe (Feline), Ft (Ferret), Fi (Fish), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Bear

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E)

Background of Neuronal acetylcholine receptor subunit alpha-6 antibody

Neurol nicotinic acetylcholine receptors (ChRs) belong to the superfamily of ligand-gated ion channels and are widely expressed throughout the central and peripheral nervous systems. ChRs play crucial roles in modulating a wide range of higher cognitive functions by mediating presyptic, postsyptic, and extrasyptic sigling.Nicotinic acetylcholine receptors containing a6 subunits (ChRa6) exhibit a unique expression pattern in the mammalian brain. ChRs a6 are abundantly expressed in the midbrain dopaminergic (DAergic) system, including mesocorticolimbic and nigrostriatal pathways, and particularly present in presyptic nerve termils. ChRa6 expressed on DAergic neurons can be activated by endogenous acetylcholine (Ach) or exogenous nicotine and alogs, which suggests that the activation of ChRa6 may play a vital role in central cholinergic circuits, including modulation of locomotor behaviour and drug addiction. In addition, ChRa6 is particularly susceptible to nigrostriatal damage, which may lead to Parkinsonâ??s disease (PD). ChRa6 are also expressed by sensory neurons; therefore, they may also play a role in disorders related to sensory perception.

General readings

Keskitalo Vuokko k., et al. (2011) Nicotine Tob Res. 13(8): 686-90.
Groot Kormrlink P J., et al. (2004) J Gen Physiol. 123: 697-708.

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neuronal acetylcholine receptor subunit alpha-6 antibody

  Rabbit Polyclonal Anti-Nicotinic Acetylcholine Receptor Alpha6 (extracellular)  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1,2. Anti-Nicotinic Acetylcholine Receptor a6(extracellular) antibody, (1:1000). 3,4. Anti-Nicotinic Acetylcholine Receptor a6(extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit alpha-6 antibody

  Rabbit Polyclonal Anti-CHRNA6 Antibody  
CHRNA6 (cholinergic receptor, nicotinic, alpha 6) Antibody (against the N terminal of CHRNA6) (50ug) validated by WB using THP-1 cell lysate at 0.2-1 ug/ml. Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit alpha-6 (91-103) antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Av, Bear, Bov, Can, Elephant, Eq, Fe, Fi, Ft, GP, Hst, Hu, Mky, Op, Platypus, Por, Prim, Rb P
50 µg / €470.00
  Acris Antibodies GmbH

Neuronal acetylcholine receptor subunit alpha-6 antibody

Neuronal acetylcholine receptor subunit alpha-6 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CHRNA6 - human gene knockout kit via CRISPR

CHRNA6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CHRNA6 - human gene knockout kit via CRISPR

CHRNA6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CHRNA6 - human gene knockout kit via CRISPR

CHRNA6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CHRNA6 - human gene knockout kit via CRISPR

CHRNA6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Chrna6 - mouse gene knockout kit via CRISPR

Chrna6 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neuronal acetylcholine receptor subunit alpha-6 (26-239, His-tag)

Neuronal acetylcholine receptor subunit alpha-6 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Neuronal acetylcholine receptor subunit alpha-6 (26-239, His-tag)

Neuronal acetylcholine receptor subunit alpha-6 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

CHRNA6 overexpression lysate

CHRNA6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CHRNA6 (Myc-DDK tagged) - Human cholinergic receptor, nicotinic, alpha 6 (CHRNA6), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CHRNA6 (Myc-DDK tagged) - Human cholinergic receptor, nicotinic, alpha 6 (CHRNA6), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Chrna6 (GFP-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 6 (Chrna6), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna6 (GFP-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 6 (Chrna6), 200 uL, >10^7 TU/mL  
200 µl / €1,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, Chrna6 (Myc-DDK-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 6 (Chrna6), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna6 (Myc-DDK-tagged) - Mouse cholinergic receptor, nicotinic, alpha polypeptide 6 (Chrna6), 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Chrna6 (GFP-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 6 (Chrna6), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna6 (GFP-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 6 (Chrna6), 200 uL, >10^7 TU/mL  
200 µl / €1,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, Chrna6 (Myc-DDK-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 6 (Chrna6), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chrna6 (Myc-DDK-tagged ORF) - Rat cholinergic receptor, nicotinic, alpha 6 (Chrna6), 200 uL, >10^7 TU/mL  
200 µl / €993.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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