Neuronal acetylcholine receptor subunit beta-2 antibody

Principal name

Neuronal acetylcholine receptor subunit beta-2 antibody

Alternative names for Neuronal acetylcholine receptor subunit beta-2 antibody

Nicotinic acetylcholine receptor subunit beta 2, CHRNB2

SwissProt ID

P09484 (Chick), P12390 (Rat), P17787 (Human), Q9ERK7 (Mouse)

Gene ID

1141 (CHRNB2), 395605, 54239 (Chrnb2)

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog, Can (Canine), GP (Guinea Pig), Ye (Yeast)

Available hosts

Goat, Rabbit, Rat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of Neuronal acetylcholine receptor subunit beta-2 antibody

Acetylcholine, released by cholinergic neurons, activates two groups of acetylcholine receptors (AChRs); muscarinic AChRs (mAChRs) which belong to the superfamily of G-protein coupled receptors (GPCRs) and nicotinic AChRs (ChRs) which belong to the ligand-gated ion channel superfamily. ChRs also respond to nicotine, hence their me.To date, 17 different but related subunits of ChRs have been identified and cloned. They consist of a subunits (a1-10), which is responsible for the binding of ligands. In fact, this subunit includes a Cys-loop in the first extracellular domain that is required for agonist binding. The other subunits responsible for making up the active receptor are the Ã? (Ã?1-4), ?, d and e subunits. Structurally, all subunits have the following: a conserved large extracellular N-termil domain, 3 conserved transmembrane domains, a variable cytoplasmic loop and a fourth transmembrane domain with a short extracellular C-termil domain. An active ChR is generally a heteropentamer of these various subunits organized around a central pore.While most Ã? subunits are neurol, the Ã?1 subunit forms functiol receptors along with other subunits in the muscle. The diversity of these receptors and their functiol organization gives rise to unique properties and functions. The a4Ã?2 receptor composition makes up a high affinity nicotinic receptor. In fact, its upregulation (mainly expressed by the increase of functiol receptors at the membrane and not expression per se) is responsible for the increased appearance of binding sites following nicotine administrationimal studies have shown that ChR-related mechanisms are involved in attention function. Indeed a4Ã?2 ChR seems to also be involved in attention-deficit hyperactivity disorder (ADHD), a disease distinguished by a lack of attention, distractibility and hyperactivity. The a4Ã?2 and a7 ChRs appear to be critical in rats for attention and working memory. Also, a a4Ã?2 specific agonist was shown to reduce impulsivity, hyperactivity and attention deficits in adults with ADHD5. This same receptor subtype may also be involved in Parkinsonâ??s disease (PD) as smoking and a4Ã?2 ChR agonists show beneficial effects in PD.

General readings

Cook LJ, Ho LW, Taylor AE, Brayne C, Evans JG, Xuereb J, Cairns NJ, Pritchard A, Lemmon H, Mann D, St Clair D, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Owen MJ, Williams J, Lendon C, Rubinsztein DC.
Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease.
Neurosci Lett. 2004 Mar 25;358(2):142-6.
PMID: 15026168

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neuronal acetylcholine receptor subunit beta-2 antibody

TA305621 (1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit beta-2 antibody

Western blot analysis of SH-SY5Y human neuroblastoma cell lysate (lanes 1 and 4) and rat (lanes 2 and 5) and mouse (lanes 3 and 6) brain lysate: 1-3. Anti-Nicotinic Acetylcholine Receptor ß2(extracellular) antibody, (1:200). 4-6. Anti-Nicotinic Acetylcholine Receptor ß2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit beta-2 antibody

WB Suggested Anti-CHRNB2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit beta-2 antibody

WB Suggested Anti-CHRNB2 Antibody; Titration: 1.25 ug/ml; Positive Control: HepG2 Whole Cell Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit beta-2 antibody

WB Suggested Anti-CHRNB2 Antibody Titration: 5.0ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt, Ye WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit beta-2 antibody

WB Suggested Anti-CHRNB2 Antibody Titration: 2.5 ug/ml; Positive Control: Jurkat cell lysate CHRNB2 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuronal acetylcholine receptor subunit beta-2 antibody

Neuronal acetylcholine receptor subunit beta-2 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Neuronal acetylcholine receptor subunit beta-2 antibody

Neuronal acetylcholine receptor subunit beta-2 Rabbit Purified Hu C, E, WB
25 µg / €310.00
  Acris Antibodies GmbH

Neuronal acetylcholine receptor subunit beta-2 (C-term) antibody

Neuronal acetylcholine receptor subunit beta-2 Rabbit Serum Hu C, E, ICC/IF, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Neuronal acetylcholine receptor subunit beta-2 antibody

Neuronal acetylcholine receptor subunit beta-2 Mouse IgG2a 1C7 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neuronal acetylcholine receptor subunit beta-2 antibody

Human kidney; CHRNB2 antibody - middle region (ARP34970_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Por, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Neuronal acetylcholine receptor subunit beta-2 antibody

Human HepG2; WB Suggested Anti-CHRNB2 Antibody Titration: 5.0ug/ml. ELISA Titer: 1:312500. Positive Control: HepG2 cell lysate; CHRNB2 antibody - middle region (ARP37669_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Por, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

Neuronal acetylcholine receptor subunit beta-2 antibody

Human HepG2; WB Suggested Anti-CHRNB2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; CHRNB2 antibody - N-terminal region (AVARP13020_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Neuronal acetylcholine receptor subunit beta-2 antibody

Human HepG2; WB Suggested Anti-CHRNB2 Antibody. . Titration: 1.25 ug/ml. . Positive Control: HepG2 Whole Cell; CHRNB2 antibody - N-terminal region (AVARP13020_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Neuronal acetylcholine receptor subunit beta-2 antibody

Western Blot: CHRNB2 Antibody [NBP1-28467]-(1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neuronal acetylcholine receptor subunit beta-2

Neuronal acetylcholine receptor subunit beta-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Neuronal acetylcholine receptor subunit beta-2

Neuronal acetylcholine receptor subunit beta-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

17 Item(s)

per page
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