Neuropilin 2 antibody

Principal name

Neuropilin 2 antibody

Alternative names for Neuropilin 2 antibody

NRP2, VEGF165R2, Vascular endothelial cell growth factor 165 receptor 2

SwissProt ID

O35276 (Rat), O35375 (Mouse), O60462 (Human)

Gene ID

81527 (Nrp2), 8828 (NRP2)

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse)

Available hosts


Available applications

Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Neuropilin 2 antibody

NRP2(Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped to 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3 (PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in NRP2- brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of NRP2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons.

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