Neuroserpin / SERPINI1 antibody

Principal name

Neuroserpin / SERPINI1 antibody

Alternative names for Neuroserpin / SERPINI1 antibody

Serpin I1, PI12, PI-12, Peptidase inhibitor 12

SwissProt ID

O35684 (Mouse), Q90935 (Chick), Q99574 (Human), Q9JLD2 (Rat)

Gene ID

5274 (SERPINI1), 20713 (Serpini1)

Available reactivities

Hu (Human), Ms (Mouse), Chimp (Chimpanzee), Rt (Rat), Bov (Bovine), Por (Porcine), Can (Canine), Eq (Equine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Goat, Rabbit, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot)

Background of Neuroserpin / SERPINI1 antibody

Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala. The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB).

General readings

Onda M, Belorgey D, Sharp LK, Lomas DA. Latent Ser49Pro neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies. J Biol Chem. 2005 Jan 21; [Epub ahead of print]

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neuroserpin / SERPINI1 antibody

TA303009 (1µg/ml) staining of Human Brain  lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Chimp, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuroserpin / SERPINI1 antibody

Predicted band size: 46 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neuroserpin / SERPINI1 antibody

To detect Human Neuroserpin by direct ELISA (using 100 ml/well) a concentration of approximately 1.0 ug/ml of this antibody is required. This biotinylated polyclonal antibody allows the detection of at least 0.2-0.4 ng/well of recombinant Human Neuroserpin. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuroserpin / SERPINI1 antibody

To detect hNeuroserpin by sandwich ELISA (using 100ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human Neuroserpin (TA328402) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeuroserpin. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuroserpin / SERPINI1 antibody

WB Suggested Anti-SERPINI1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: NCI-H226 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neuroserpin / SERPINI1 antibody

Western blot analysis of extract from Mouse brain tissue using Neuroserpin Antibody Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neuroserpin / SERPINI1 antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1D10 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Neuroserpin / SERPINI1 antibody

Western blot (WB) analysis of Neuropsin antibody (Cat.-No.: AP01329PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Neuroserpin / SERPINI1 (N-term) antibody

Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SERPINI1 antibody (N-term) Cat.-No AP53865PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SERPINI1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Neuroserpin / SERPINI1 antibody

Immunoperoxidase of monoclonal antibody to SERPINI1 on formalin-fixed paraffin-embedded human cerebral cortex. [antibody concentration 3 ug/ml] Mouse IgG1 1D10 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neuroserpin / SERPINI1 antibody

SERPINI1 monoclonal antibody (M03), clone 1E10. Western Blot analysis of SERPINI1 expression in HeLa ( Cat # L013V1 ). Mouse IgG1 1E10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neuroserpin / SERPINI1 antibody

SERPINI1 polyclonal antibody ( Cat # PAB6763 ) ( 1 µg/ml ) staining of human brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Neuroserpin / SERPINI1 antibody

Human NCI-H226; WB Suggested Anti-SERPINI1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: NCI-H226 cell lysate; SERPINI1 antibody - middle region (ARP56616_P050) in Human NCI-H226 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Neuroserpin / SERPINI1 antibody

Western Blot: Neuroserpin Antibody [NB100-1528] - NB100-1529 (1ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Neuroserpin / SERPINI1 antibody

Western Blot: Neuroserpin Antibody [NBP1-31037] - Western blot analysis of Neuroserpin Antibody on: A:A431 B:HeLa S3 C:Hep G2 10% SDS PAGE diluted at 1:1500 Rabbit IgG Hu Dot, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Neuroserpin / SERPINI1 antibody

Immunohistochemistry-Paraffin: Neuroserpin Antibody [NBP1-82587] Immunohistochemical staining of human lateral ventricle shows strong cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neuroserpin / SERPINI1 (transcript variant 1)

Neuroserpin / SERPINI1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 25 µg / €199.00

Special Price: 25 µg / €139.00

  OriGene Technologies, Inc.

Neuroserpin / SERPINI1

Neuroserpin / SERPINI1 Human Purified > 96 % pure by SDS-PAGE gel and HPLC analyses E. coli
25 µg / €230.00
  Acris Antibodies GmbH

Neuroserpin / SERPINI1

Neuroserpin / SERPINI1 Human Purified > 96 % pure by SDS-PAGE gel and HPLC analyses E. coli
5 µg / €140.00
  Acris Antibodies GmbH

Neuroserpin / SERPINI1

Neuroserpin / SERPINI1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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