Neurotensin receptor 1 antibody

Principal name

Neurotensin receptor 1 antibody

Alternative names for Neurotensin receptor 1 antibody

NT-R-1,NTSR1, NTRR, NTR1, High-affinity levocabastine-insensitive neurotensin

SwissProt ID

O88319 (Mouse), P20789 (Rat), P30989 (Human)

Gene ID

4923 (NTSR1), 18216 (Ntsr1), 366274

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Guinea Pig, Rabbit, Mouse, Chicken

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Functional assay (FN), Frozen Sections (C)

Background of Neurotensin receptor 1 antibody

Neurotensin receptor 1 (NTS1) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestil tract. NTS1 and NTS2 belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily while the third neurotensin receptor NTS3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTS1 and NTS3 bind neurotensin with high affinity while NTS2 binds it with low affinity. NTS1 sigls preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+ mobilization, although coupling with Gi/o and to Gs has been observed in some expression systems. NTS1 is mainly expressed in the brain and gastrointestil tract. In the brain, NTS1 mediates body temperature regulation, feeding behavior and locomotion regulation. One of the best studied roles of NTS1 is the regulation of dopamine release suggesting that NTS1 can be a suitable target for the development of a new class of anti-psychotics. In the periphery, NTS1 expression has been linked to the control of intestine motility and in the stimulation of growth of the intestine mucosa in both physiological and pathological conditions. NTS1 has been shown to be upregulated in several human cancers where it stimulates tumor growth in response to locally produced neurotensin peptide.

General readings

Ovigne J.M. et al, Neuropeptides 3 : 247-256 (1998)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neurotensin receptor 1 (N-term) antibody

  Rabbit Polyclonal Anti-NTSR1 Antibody (N-Terminus)  
Anti-NTSR1 / NTR antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

  Rabbit Polyclonal Anti-NTSR1 Antibody (Cytoplasmic Domain)  
Anti-NTSR1 / NTR antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

  Rabbit polyclonal anti-NTR1 antibody  
Western blot analysis of extracts from Jurkat cells, using NTR1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

  Anti-NTSR1 Rabbit Polyclonal Antibody  
Predicted band size: 46 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/200-1000. (Gel: %SDS-PAGE Lysate: 40 ug Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

  NTSR1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of Jurkat cell line, using NTSR1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

  Rabbit Polyclonal Anti-Neurotensin Receptor 1 (extracellular)  
Western blot analysis of human colon cancer HT-29 (lanes 1 and 4), human lung small cell carcinoma NCI-H526 (lanes 2 and 5) and human breast adenocarcinoma MDA-MB-468 (lanes 3 and 6) cell lysates: 1-3. Anti-Neurotensin Receptor 1 (extracellular) antibody, (1:200). 4-6. Anti-Neurotensin Receptor 1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

  Rabbit Polyclonal Anti-NTSR1 Antibody (C-Terminus)  
Anti-NTSR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

  Rabbit Polyclonal Anti-NTSR1 Antibody  
WB Suggested Anti-NTSR1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: OVCAR-3 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neurotensin receptor 1 antibody

A typical staining pattern with the B-N6 monoclonal antibody of NTR transfected CHO cell line Mouse IgM B-N6 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

Neurotensin receptor 1 antibody

A typical staining pattern with the B-N6 monoclonal antibody of NTR transfected CHO cell line Mouse IgM B-N6 Purified Hu F
2ml (200 Tests) / €250.00
  Acris Antibodies GmbH

Neurotensin receptor 1 antibody

Western blot (WB) analysis of NTR1 antibody (Cat.-No.: AP01325PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Neurotensin receptor 1 antibody

Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Neurotensin receptor 1 antibody

Western blot analysis of extracts from MCF7 cells, using NTR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

Neurotensin receptor 1 antibody

Western blot analysis of extracts from MCF7 cells, using NTR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

Neurotensin receptor 1 antibody

Immuofluorescent detection of NTS1 in cell bodies of neurons in rat dorsal root ganglia (red fluorescence). Chicken Aff - Purified Ms C, ICC/IF
0.1 ml / €350.00
  Neuromics Antibodies

Neurotensin receptor 1 antibody

Expression of NTS1 receptors in sensory neurons and spinal cord. (a) Immunoperoxidase staining reveals the presence of NTS1-like immunoreactivity throughout the lumbar dorsal horn of the spinal cord. Immunolabeling is most prominent in the superficial layers of the dorsal horn. The lateral spinal nucleus (lsn) is also moderately labeled (arrow). (b) High magnification of (a). A dense NTS1 immunostaining is observed over laminae I and II of the dorsal horn. Numerous immunopositive nerve cell bodies are visible in the superficial laminae and in the nucleus proprius of the dorsal horn (arrows). (c) Light microscopic analysis of NTS1 expression in primary afferent neurons. NTS1 is expressed in subpopulations of small- and medium-ganglion cells. No apparent labeling is detected in large DRG neurons (arrows). At higher magnification, NTS1 neurons exhibit a cytoplasmic pattern of immunoreactivity (d, arrowheads). (e) Identification of endogenously expressed NTS1 receptors, by western blotting, in homogenates from DRGs, lumbar spinal cord and brain. The 47 kDa protein band corresponds to the molecular weight deduced from the cDNA sequence of NTS1. Each lane represents the transfer of 25 lg of protein. Scale bars: (a, b, c, and d) 300, 150, 70 and 20 lm, respectively. doi:10.1111/j.1471-4159.2007.05205.x. Guinea Pig Serum Rt ICC/IF
50 µl / €230.00
  Neuromics Antibodies

Neurotensin receptor 1 antibody

Expression of NTS1 receptors in sensory neurons and spinal cord. (a) Immunoperoxidase staining reveals the presence of NTS1-like immunoreactivity throughout the lumbar dorsal horn of the spinal cord. Immunolabeling is most prominent in the superficial layers of the dorsal horn. The lateral spinal nucleus (lsn) is also moderately labeled (arrow). (b) High magnification of (a). A dense NTS1 immunostaining is observed over laminae I and II of the dorsal horn. Numerous immunopositive nerve cell bodies are visible in the superficial laminae and in the nucleus proprius of the dorsal horn (arrows). (c) Light microscopic analysis of NTS1 expression in primary afferent neurons. NTS1 is expressed in subpopulations of small- and medium-ganglion cells. No apparent labeling is detected in large DRG neurons (arrows). At higher magnification, NTS1 neurons exhibit a cytoplasmic pattern of immunoreactivity (d, arrowheads). (e) Identification of endogenously expressed NTS1 receptors, by western blotting, in homogenates from DRGs, lumbar spinal cord and brain. The 47 kDa protein band corresponds to the molecular weight deduced from the cDNA sequence of NTS1. Each lane represents the transfer of 25 lg of protein. Scale bars: (a, b, c, and d) 300, 150, 70 and 20 lm, respectively. doi:10.1111/j.1471-4159.2007.05205.x. Guinea Pig Serum Rt ICC/IF
0.1 ml / €350.00
  Neuromics Antibodies

Neurotensin receptor 1 Control Peptide

Expression of NTS1 receptors in sensory neurons and spinal cord. (a) Immunoperoxidase staining reveals the presence of NTS1-like immunoreactivity throughout the lumbar dorsal horn of the spinal cord. Immunolabeling is most prominent in the superficial layers of the dorsal horn. The lateral spinal nucleus (lsn) is also moderately labeled (arrow). (b) High magnification of (a). A dense NTS1 immunostaining is observed over laminae I and II of the dorsal horn. Numerous immunopositive nerve cell bodies are visible in the superficial laminae and in the nucleus proprius of the dorsal horn (arrows). (c) Light microscopic analysis of NTS1 expression in primary afferent neurons. NTS1 is expressed in subpopulations of small- and medium-ganglion cells. No apparent labeling is detected in large DRG neurons (arrows). At higher magnification, NTS1 neurons exhibit a cytoplasmic pattern of immunoreactivity (d, arrowheads). (e) Identification of endogenously expressed NTS1 receptors, by western blotting, in homogenates from DRGs, lumbar spinal cord and brain. The 47 kDa protein band corresponds to the molecular weight deduced from the cDNA sequence of NTS1. Each lane represents the transfer of 25 lg of protein. Scale bars: (a, b, c, and d) 300, 150, 70 and 20 lm, respectively. doi:10.1111/j.1471-4159.2007.05205.x. Purified
0.1 mg / €150.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Ntsr1 - mouse gene knockout kit via CRISPR

Ntsr1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NTSR1 overexpression lysate

NTSR1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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