Neurotrophin 3 / NTF3 antibody

Principal name

Neurotrophin 3 / NTF3 antibody

Alternative names for Neurotrophin 3 / NTF3 antibody

Neurotrophin-3, NT-3, Neurotrophic factor, HDNF, Nerve growth factor 2, NGF-2

SwissProt ID

P18280 (Rat), P20181 (Mouse), P20783 (Human), P25433 (Chick), P25435 (Xenla), Q06AV0 (Pig), Q08DT3 (Bovin), Q9TST2 (Felca)

Gene ID

4908 (NTF3), 18205 (Ntf3), 81737

Available reactivities

Hu (Human), Rt (Rat), Chk (Chicken), Ms (Mouse), Rb (Rabbit), Bov (Bovine)

Available hosts

Goat, Mouse, Rabbit, Sheep

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Dot blot (Dot), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Neutralisation (NEUT)

Background of Neurotrophin 3 / NTF3 antibody

Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes nerve growth factor (NGF) neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). All neurotrophins are synthesized as preproneurotrophin precursors that are subsequently processed within the intracellular transport pathway to yield proneurotrophins that are further processed to generate the mature form. The mature form of BDNF is a non-covalent stable homodimer that can be secreted in both constitutive and regulated pathways. Until recently, the functiol role of the neurotrophins prodomains was thought to include assistance in the correct folding of the mature protein and the sorting of the neurotrophins into the constitutive or regulated secretory pathway. However, a growing body of evidence suggests that the uncleaved proneurotrophin precursors can be secreted from cells and that they may mediate different biological functions.Several studies implicate both proNGF and proBDNF in several physiological and pathological conditions. Today it remains to be established whether proNT-3 has similarly, different biological functions than the mature NT-3 neurotrophin.

General readings

1. Willerth SM, The effects of soluble growth factors on embryonic stem cell differentiation inside of fibrin scaffolds Stem Cells. ;25(9):2235-44 9/1/2007 17585170
2. Tauszig-Delamasure, S. The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proceedings of the National Academy of Sciences of the U S A.;104(33):13361-6. 8/14/2007 17686986
3. Rao, M.S. Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy.
Neurobiology of Disease.;27(2):117-32. 8/1/2007 17618126
4. Qin, H. Regulation of Apoptosis and Differentiation by p53 in Human Embryonic Stem Cells. Journal of Biological Chemistry.;282(8):5842-52 2/23/2007 17179143
5. Iohara K, Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells. ;24(11):2493-503. 11/1/2006 16873765
6. Cass WA, Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine Ann N Y Acad Sci. ;1074:272-81 8/1/2006 17105923
7. Soen Y, Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments Mol Syst Biol. 2006;2:37 7/4/2006 16820778
8. Takaki M, In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells Stem Cells. ;24(6):1414-22. 6/1/2006 16527901
9. Pyle AD Neurotrophins mediate human embryonic stem cell survival Nat Biotechnol. ;24(3):344-50 3/1/2006 16444268
Toma JG, Isolation and characterization of multipotent skin-derived precursors from human skin Stem Cells. ;23(6):727-37 6/1/2005 15917469
10. Yoshimura T GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity Cell; 120(1):137-49 1/14/2005 15652488
11. Fernandes KJ A dermal niche for multipotent adult skin-derived precursor cells Nature Cell Biology. 2004 Nov;6(11):1082-93 11/1/2004 15517002
12. Claudio Rivera BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion J. of Cell Bio. Vol:159 (5) pp. 747-752 12/9/2002 12473684
13. Xiao-hui Zhang Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon Neuron Vol: 36 pp. 675-688 11/1/2002 12441056
14. Kaplan MR Differential Control of Clustering of the Sodium Channels Nav1.2 and Nav1.6 at Developing CNS Nodes of Ranvier Neuron. Vol.30: pp.105-119 4/1/2001 11343648
15. Wang S A Role for the Helix-Loop-Helix Protein Id2 in the Control of Oligodendrocyte Development Neuron. Vol.29: pp.603-614 3/1/2001 11301021
16. Fernandez PA Evidence that Axon-Derived Neuregulin Promotes Oligodendrocyte Survival in the Developing Rat Optic Nerve Neuron. Volume 28. Pp.81-90 10/1/2000 11086985
17. Ohgoh, M. Astroglial trophic support and neuronal cell death: influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons. Journal of Neurochemistry.;75(3):925-33 9/1/2000 10936172
18. Salehi AH NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor-Dependent Apoptosis Neuron, Volume 27. Pp.279-288 8/2/2000 10985348
19. Johnson, J.R. Possible role of CREB in the stimulation of oligodendrocyte precursor cell proliferation by neurotrophin-3. The Journal of Neurochemistry.;74(4):1409-17. 4/1/2000 10737596
20. Tang DG Long-Term Culture of Purified Postnatal Oligodendrocyte Precursor Cells: Evidence for an Intrinsic Maturation Program that Plays out over Months The Rockefeller University Press. The Journal of Cell Biology. Volume 148. Number 5 pp. 971-984 3/6/2000 10704447
21. Sano, M. Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo. Journal of Neurochemistry.;72(6):2256-63 6/1/1999 10349833
22. Vicario-Abejon C Neurotrophins Induce Formation of Functional Excitatory and Inhibitory Synapses between Cultured Hippocampal Neurons The Journal of Neuroscience. 18(18): pp.7256-7271 9/15/1998 9736647
23. Back SA Maturation-Dependent Vulnerability of Oligodendrocyted to Oxidative Stress-Induced Death Caused by Glutathione Depletion The Journal of Neuroscience 18(16): pp 6241-6253 8/15/1998 9698317

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neurotrophin 3 / NTF3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver using anti-NTF3 (TA500115) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min). Mouse IgG2a OTI5C7 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Neurotrophin 3 / NTF3 antibody

Immunohistochemical staining of paraffin-embedded lung within the normal limits using anti-NTF3 (TA500030) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min). Mouse IgG1 OTI5A2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Neurotrophin 3 / NTF3 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-NTF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500032) Mouse IgG2a OTI3D4 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Neurotrophin 3 / NTF3 antibody

Immunohistochemistry-Paraffin: Neurotrophin 3 Antibody (5A2) [NBP1-47892] - Immunohistochemical staining of paraffin-embedded Carcinoma of lung using anti-NTF3 mouse monoclonal antibody. Mouse 5A2 Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

Neurotrophin 3 / NTF3 antibody

Western blot analysis using recombinant human NT-3. Lane 1: 200 ng, Lane 2: 500 ng. Rabbit Purified Hu WB
0.2 mg / €325.00
  OriGene Technologies, Inc.

Neurotrophin 3 / NTF3 antibody

Predicted band size: 31 kDa . Positive control: HT-29 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neurotrophin 3 / NTF3 antibody

Western blot analysis using Anti-NT-3 antibody (1:1000) (1-4) or anti-NT-3 antibody, preincubated with the control antigen peptide (5): 1. hNT-3, 10 ng 2. hß-NGF , 100 ng 3. hNT-4, 100 ng 4. hNT-3, 10 ng 5. Control peptide Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neurotrophin 3 / NTF3 antibody

Western blot analysis using Anti-proNT-3 antibody (1:600): 1. hNT-3 , (200 ng). 2. hNT-4 , (200 ng). 3. mNGF 2.5S (Grade II) , (200 ng). 4. hß-NGF, (200 ng). 5. hBDNF , (200 ng). 6. proNGF (WT-mouse), (200 ng). 7. proBDNF (WT-mouse), (200 ng). 8. recombinant proNT-3 10 ng. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Neurotrophin 3 / NTF3 antibody

Anti-NTF3 / Neurotrophin 3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

Neurotrophin 3 / NTF3 antibody

WB Suggested Anti-Ntf3 Antibody; Titration: 1.0 ug/ml; Positive Control: Rat Brain Rabbit IgG Purified Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Neurotrophin 3 / NTF3 antibody

Neurotrophin 3 / NTF3 Mouse IgM OTI2D1 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Neurotrophin 3 / NTF3 (C-term) antibody

Western blot analysis of anti-NTF3 Antibody (C-term) in mouse brain tissue lysates (35ug/lane). NTF3 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Neurotrophin 3 / NTF3 antibody

Immunohistochemical analysis of paraffin embedded rat tissue sections (brain) using NT3 antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Neurotrophin 3 / NTF3 antibody

Neurotrophin 3 / NTF3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Neurotrophin 3 / NTF3 antibody

NTF3 MaxPab rabbit polyclonal antibody. Western Blot analysis of NTF3 expression in mouse liver. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Neurotrophin 3 / NTF3 antibody

Neurotrophin 3 / NTF3 Rabbit Chk, Hu, Rt C, E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Neurotrophin 3 / NTF3 antibody

Immunohistochemical staining of NTF3 in crushed rat peripheral nerve using rabbit NTF3 polyclonal antibody ( Cat # PAB0706 ) . Rabbit Chk, Hu, Rt C, E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Neurotrophin 3 / NTF3 antibody

Immunohistochemical staining of NTF3 in rat purkinje cells of the cerebellum using rabbit NTF3 polyclonal antibody ( Cat # PAB0744 ) . Rabbit Chk, Hu, Rt C, E, WB
20 µg / €390.00
  Abnova Taiwan Corp.

Neurotrophin 3 / NTF3 antibody

Immunohistochemical analysis of paraffin-embedded rat brain sections using NTF3 polyclonal antibody ( Cat # PAB8000 ) . Rabbit Hu, Ms, Rb, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Neurotrophin 3 / NTF3 antibody

Neurotrophin 3 / NTF3 Sheep IgG Chk, Hu, Ms, Rt C, Dot, E, WB
50 µg / €390.00
  Abnova Taiwan Corp.

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