Neurotrypsin antibody

Principal name

Neurotrypsin antibody

Alternative names for Neurotrypsin antibody

PRSS12, Serine protease 12, Motopsin, Leydin

SwissProt ID

P56730 (Human)

Gene ID

8492 (PRSS12)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Neurotrypsin antibody

Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator.
There are three sequences published for neurotrypsin to date; 875, 834 and 505 amino acids in length. The predicted masses are 97, 92.5 and 55.7 kDa respectively, with predicted pI of 9.14, 8.88 and 6.57. The three forms all start at the same place. The 505 residue form terminates in the last SRCR domain, before the catalytic domain, and the 834 amino acid form has a 40 amino acid deletion that starts just after the PC site, and includes the catalytic histidine, thus both species would be proteolytically inactive.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neurotrypsin (N-term) antibody

  Rabbit Polyclonal Neurotrypsin Antibody  
Western blot analysis of neurotrypsin in SK-N-SH cell lysate with neurotrypsin antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neurotrypsin antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, Cerebellum. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Neurotrypsin antibody

Neurotrypsin Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €460.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

PRSS12 - human gene knockout kit via CRISPR

PRSS12 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PRSS12 - human gene knockout kit via CRISPR

PRSS12 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRSS12 - human gene knockout kit via CRISPR

PRSS12 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRSS12 - human gene knockout kit via CRISPR

PRSS12 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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