Neutral ceramidase / ASAH2 antibody

Principal name

Neutral ceramidase / ASAH2 antibody

Alternative names for Neutral ceramidase / ASAH2 antibody

HNAC1, BCDase, LCDase, hCD, Non-lysosomal ceramidase, N-acylsphingosine amidohydrolase 2, Acylsphingosine deacylase 2, N-acylsphingosine amidohydrolase 2

SwissProt ID

Q5W7F1 (Danre), Q91XT9 (Rat), Q9JHE3 (Mouse), Q9NR71 (Human)

Gene ID

56624 (ASAH2), 54447 (Asah2), 114104

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Neutral ceramidase / ASAH2 antibody

Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neutral ceramidase / ASAH2 antibody

  Rabbit Polyclonal ASAH2 Antibody  
Western blot analysis of ASAH2 in 293 cell lysate with ASAH2 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neutral ceramidase / ASAH2 (C-term) antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Neutral ceramidase / ASAH2 antibody

Western blot analysis of ASAH2 expression in Jurkat cell lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Neutral ceramidase / ASAH2 antibody

Western blot analysis of ASAH2 in 293 cell lysate with ASAH2 polyclonal antibody ( Cat # PAB13057 ) at ( A ) 1 and ( B ) 2 µg/ml. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

ASAH2 - human gene knockout kit via CRISPR

ASAH2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ASAH2 - human gene knockout kit via CRISPR

ASAH2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asah2 - mouse gene knockout kit via CRISPR

Asah2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Asah2 - mouse gene knockout kit via CRISPR

Asah2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asah2 - mouse gene knockout kit via CRISPR

Asah2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asah2 - mouse gene knockout kit via CRISPR

Asah2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ASAH2 overexpression lysate

ASAH2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ASAH2 (mGFP-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ASAH2 (mGFP-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,870.00
  OriGene Technologies, Inc.

Lenti ORF particles, ASAH2 (mGFP-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ASAH2 (mGFP-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.

Lenti ORF particles, ASAH2 (Myc-DDK-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ASAH2 (Myc-DDK-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,680.00
  OriGene Technologies, Inc.

Lenti ORF particles, ASAH2 (Myc-DDK-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ASAH2 (Myc-DDK-tagged)-Human N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (ASAH2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,530.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Asah2 (GFP-tagged) - Mouse N-acylsphingosine amidohydrolase 2 (Asah2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asah2 (GFP-tagged) - Mouse N-acylsphingosine amidohydrolase 2 (Asah2), 200 uL, >10^7 TU/mL  
200 µl / €1,460.00
  OriGene Technologies, Inc.

Lenti ORF particles, Asah2 (Myc-DDK-tagged) - Mouse N-acylsphingosine amidohydrolase 2 (Asah2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asah2 (Myc-DDK-tagged) - Mouse N-acylsphingosine amidohydrolase 2 (Asah2), 200 uL, >10^7 TU/mL  
200 µl / €1,310.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Asah2 (GFP-tagged ORF) - Rat N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (Asah2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asah2 (GFP-tagged ORF) - Rat N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (Asah2), 200 uL, >10^7 TU/mL  
200 µl / €1,460.00
  OriGene Technologies, Inc.

Lenti ORF particles, Asah2 (Myc-DDK-tagged ORF) - Rat N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (Asah2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asah2 (Myc-DDK-tagged ORF) - Rat N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (Asah2), 200 uL, >10^7 TU/mL  
200 µl / €1,314.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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