Neutral ceramidase / ASAH2 antibody

Principal name

Neutral ceramidase / ASAH2 antibody

Alternative names for Neutral ceramidase / ASAH2 antibody

HNAC1, BCDase, LCDase, hCD, Non-lysosomal ceramidase, N-acylsphingosine amidohydrolase 2, Acylsphingosine deacylase 2, N-acylsphingosine amidohydrolase 2

SwissProt ID

Q5W7F1 (Danre), Q91XT9 (Rat), Q9JHE3 (Mouse), Q9NR71 (Human)

Gene ID

56624 (ASAH2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Neutral ceramidase / ASAH2 antibody

Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neutral ceramidase / ASAH2 antibody

Western blot analysis of ASAH2 in 293 cell lysate with ASAH2 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neutral ceramidase / ASAH2 (C-term) antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Neutral ceramidase / ASAH2 Control Peptide

Neutral ceramidase / ASAH2
50 µg / €160.00
  Acris Antibodies GmbH

Neutral ceramidase / ASAH2 antibody

Western blot analysis of ASAH2 expression in Jurkat cell lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Neutral ceramidase / ASAH2 antibody

Western blot analysis of ASAH2 in 293 cell lysate with ASAH2 polyclonal antibody ( Cat # PAB13057 ) at ( A ) 1 and ( B ) 2 µg/ml. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Neutral ceramidase / ASAH2 antibody

Neutral ceramidase / ASAH2 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Neutral ceramidase / ASAH2 antibody

Western Blot: NAAA Antibody [NBP1-76360] - Analysis of ASAH2 in 293 cell lysate with ASAH2 antibody at (A) 1 and (B) 2 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

ASAH2 overexpression lysate

ASAH2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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