Neutrophil antibiotic peptide NP-5 antibody

Principal name

Neutrophil antibiotic peptide NP-5 antibody

Alternative names for Neutrophil antibiotic peptide NP-5 antibody

Microbicidal peptide NP-5

SwissProt ID

P07466 (Rabit)

Gene ID

100009136 (LOC100009136)

Available reactivities

Rb (Rabbit)

Available hosts


Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C)

Background of Neutrophil antibiotic peptide NP-5 antibody

Alpha defensins belong together with the ß-defensins to the family of cationic trisulfide-containing microbicidal peptides. They exert their microbicidal activity by permeating the membrane involving the formation of voltage regulated ion channels. Rabbit neutrophils contain large amount of alpha defensins (Neutrophil Defensin) NP 1 - 6. Defensins constitute more than 15% of total protein in rabbit neutrophils and are accumulated in dense cytoplasmic granules. Rabbit neutrophils express all six rabbit alpha-defensins, NP 1 - 6. Among myeloid rabbit alpha-defensins NP 1 - 6, NP 3 - 6 are neutrophil specific, while NP 1 - 2 are expressed in rabbit alveolar macrophages. Defensins are relatively resistant to proteolysis, low pH and boiling. Rabbit neutrophil defensins, whose three-dimensiol structures are very similar to those of human alpha defensins may be helpful in understanding the role of antimicrobial peptides in innate and acquired immunity and in the studies on the role of neutrophils in pathological situations and in various rabbit models of human diseases.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neutrophil antibiotic peptide NP-5 antibody

Neutrophil antibiotic peptide NP-5 Mouse IgG2a R3 Purified Rb C, E, P, WB
  Acris Antibodies GmbH

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