Neutrophil elastase antibody

Principal name

Neutrophil elastase antibody

Alternative names for Neutrophil elastase antibody

ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE

SwissProt ID

P08246 (Human), Q3UP87 (Mouse)

Gene ID

1991 (ELANE), 8619916 (act22)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit, Sheep

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Flow Cytometry (F), Western blot / Immunoblot (WB), Radioimmunoassay (R), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Neutrophil elastase antibody

The human organism reacts with an inflammatory response to attacks of invading pathogens (microorganisms and viruses) or damaged tissue (after accidents or surgery). Polymorphonuclear (PMN) granulocytes play an important role as primary defence cells in this inflammatory reaction. Different bloodstream mediators (cytokines, leukotrienes, complement factors, bacterial endotoxins, clotting and fibrinolysis factors) attract and stimulate these cells to phagocytize and destroy not naturally occurring agents. PMN granulocytes use proteinases to digest these agents and tissue debris. One of these proteinases is PMN elastase which is localised in the azurophilic granules of the polymorphonuclear granulocytes. During phagocytosis of foreign substances these enzymes are also partially excreted into the extracellular surrounding, where the activity of PMN elastase is regulated by inhibitors (esp. the alpha 1-proteinase inhibitor, alpha 1- PI). An overwhelming release of PMN elastase, however, can exceed the inhibitory potential of the alpha 1-proteinase inhibitor. Thus, enzymatically active PMN elastase, together with simultaneously produced oxidants (O2-radicals, H2O, OH-radicals), can cause local tissue injury. Due to the bloodstream and lymphatic system, however, alpha 1-PI is delivered subsequently and eventually able to form a complex with all excreted elastase. Therefore, the concentration of the PMN elastase/alpha 1- PI complex correlates with the released PMN elastase and can be used as a measure for the activity of granulocytes during an inflammatory response. Primarily, determinations of PMN elastase find its application in observation of the course of trauma, shock and sepsis. Further indications are the areas of hemodialysis, infections by obstetrics, joint diseases, effusions of sport injuries, intestinal affection, pancreatitis, cystic fibrosis and male adnex affections.

General readings

Kallquist, L. et al., Exp. Cell Res. 316(19): 3182-3196 (2010)
Rabai, G. et al., Thromb. Res. 126 (2): e94-E101 (2010)
Newburger, P.E. et al., Pediatr Blood Cancer 55(2): 314-317 (2010)
Hayashi, M. et al., J Nippon Med Sch 77(2): 80-85 (2010)
Hector, A. et al., Mediators Inflamm. 2010: 809591 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG1 265-3K1 Hu E, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Neutrophil elastase Goat Serum Hu E, R, WB
0.1 ml / €250.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Neutrophil elastase Goat Serum Hu E, R, WB
20 µl / €130.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Sheep Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

Neutrophil elastase (N-term) antibody

Western blot analysis in A2058 cell line lysates (35ug/lane) using Neutrophil elastase antibody Cat.-No. AP52858PU-N (N-term). This demonstrates this antibody detected the Neutrophil elastase protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG1 39A Purified Hu E, F, FN
0.2 mg / €360.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Neutrophil elastase Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG2a 4E11 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Detection limit for recombinant GST tagged ELA2 is approximately 1ng/ml as a capture antibody. Mouse IgG2a 4B11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG2a 4E12 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Detection limit for recombinant GST tagged ELA2 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 4E12 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Detection limit for recombinant GST tagged ELA2 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 3E5 Purified Hu E
50 µg / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG2a 3E5 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG1 3B1 Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG1 3B1 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Detection limit for recombinant GST tagged ELA2 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 1A11 Purified Hu E
50 µg / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG2a 1A11 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG2b 2D10 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgM Hu E, R
0.1 mg / €390.00
  Abnova Taiwan Corp.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgM Hu E, R
0.1 mg / €390.00
  Abnova Taiwan Corp.

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