Neutrophil elastase antibody

Principal name

Neutrophil elastase antibody

Alternative names for Neutrophil elastase antibody

ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE

SwissProt ID

P08246 (Human), Q3UP87 (Mouse)

Gene ID

1991 (ELANE), 50701

Available reactivities

Hu (Human)

Available hosts

Mouse, Goat, Sheep, Rabbit

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Flow Cytometry (F), Western blot / Immunoblot (WB), Radioimmunoassay (R), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of Neutrophil elastase antibody

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

General readings

Kallquist, L. et al., Exp. Cell Res. 316(19): 3182-3196 (2010)
Rabai, G. et al., Thromb. Res. 126 (2): e94-E101 (2010)
Newburger, P.E. et al., Pediatr Blood Cancer 55(2): 314-317 (2010)
Hayashi, M. et al., J Nippon Med Sch 77(2): 80-85 (2010)
Hector, A. et al., Mediators Inflamm. 2010: 809591 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Neutrophil elastase antibody

  Mouse monoclonal Anti-Neutrophil elastase Clone NP57  
Neutrophil elastase Mouse IgG1 NP57 Purified Hu ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Neutrophil elastase antibody

  Rabbit Monoclonal anti-Neutrophil Elastase Antibody  
Human tonsil stained with anti-neutrophil elastase antibody. Rabbit IgG SP203. Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG1 265-3K1 Hu E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Neutrophil elastase Goat Serum Hu E, R, WB
0.1 ml / €250.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Neutrophil elastase Goat Serum Hu E, R, WB
20 µl / €130.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Sheep Purified Hu E, Ie, P
50 µg / €470.00
  Acris Antibodies GmbH

Neutrophil elastase (N-term) antibody

Western blot analysis in A2058 cell line lysates (35ug/lane) using Neutrophil elastase antibody Cat.-No. AP52858PU-N (N-term). This demonstrates this antibody detected the Neutrophil elastase protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Neutrophil elastase antibody

Neutrophil elastase Mouse IgG1 39A Purified Hu E, F, FN
0.2 mg / €360.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ELANE - human gene knockout kit via CRISPR

ELANE - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ELANE - human gene knockout kit via CRISPR

ELANE - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ELANE - human gene knockout kit via CRISPR

ELANE - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ELANE - human gene knockout kit via CRISPR

ELANE - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Elane - mouse gene knockout kit via CRISPR

Elane - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Elane - mouse gene knockout kit via CRISPR

Elane - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Neutrophil elastase

Neutrophil elastase Human Purified > 95 % pure by SDS-PAGE Neutrophils
0.1 mg / €480.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

ELANE overexpression lysate

ELANE overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ELANE (mGFP-tagged) - Human elastase, neutrophil expressed (ELANE), 200 uL, >10^7 TU/mL

Lenti ORF particles, ELANE (mGFP-tagged) - Human elastase, neutrophil expressed (ELANE), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, ELANE (Myc-DDK tagged) - Human elastase, neutrophil expressed (ELANE) , 200 uL, >10^7 TU/mL

Lenti ORF particles, ELANE (Myc-DDK tagged) - Human elastase, neutrophil expressed (ELANE) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Elane (GFP-tagged) - Mouse elastase, neutrophil expressed (Elane), 200 uL, >10^7 TU/mL

Lenti ORF particles, Elane (GFP-tagged) - Mouse elastase, neutrophil expressed (Elane), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Elane (Myc-DDK-tagged) - Mouse elastase, neutrophil expressed (Elane), 200 uL, >10^7 TU/mL

Lenti ORF particles, Elane (Myc-DDK-tagged) - Mouse elastase, neutrophil expressed (Elane), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

20 Item(s)

per page
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