NFKB2 / NF-kappa-B p100/p52 antibody

Principal name

NFKB2 / NF-kappa-B p100/p52 antibody

Alternative names for NFKB2 / NF-kappa-B p100/p52 antibody

LYT10, KBF2, H2TF1, NF-kB p100, NF-kB p52, NF kappa B, Nuclear factor NF-kappa-B p100 subunit, DNA-binding factor KBF2, Lymphocyte translocation chromosome 10, Oncogene Lyt-10

SwissProt ID

O73630 (Xenla), P98150 (Chick), Q00653 (Human), Q9WTK5 (Mouse)

Gene ID

4791 (NFKB2), 18034 (Nfkb2)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of NFKB2 / NF-kappa-B p100/p52 antibody

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing.

General readings

Xiao,G., et al., (2004) J. Biol. Chem. 279 (29), 30099-30105

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NFKB2 / NF-kappa-B p100/p52 antibody

Western blot analysis of extracts from RAW264.7 cells, using NF-kappaB p100/p52 (Ab-869) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NFKB2 / NF-kappa-B p100/p52 antibody

Predicted band size: 97 kDa . Positive control: HT-29 and SKOV3 cell lysate. Recommended dilution: 1/1000-5000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NFKB2 / NF-kappa-B p100/p52 antibody

Predicted cell location: Cytoplasm. Positive control: Human cervical cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using NFKB2 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NFKB2 / NF-kappa-B p100/p52 antibody

Western blot analysis of NF-kappaB p100/p52 expression in ovarycancer whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NFKB2 / NF-kappa-B p100/p52 antibody

Western blot analysis of extracts of various cell lines, using NFKB2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

NFKB2 / NF-kappa-B p100/p52 pSer865 antibody

NFKB2 / NF-kappa-B p100/p52 Rabbit Aff - Purified Hu, Ms E, IP, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 pSer869 antibody

Immunohistochemistry (IHC) analysis of NFκB-p100/p52 antibody (Cat.-No.: AP01642PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms E, IP, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

Figure 1. Immunohistochemical analysis of Paraffin-Embedded Human breast carcinoma tissue using NFκB-p100/p52 antibody AP02558PU (Left) or the same antibody preincubated with Blocking peptide (Right) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

Figure 1. Immunohistochemical analysis of Paraffin-Embedded Human breast carcinoma tissue using NFκB-p100/p52 antibody AP02558PU (Left) or the same antibody preincubated with Blocking peptide (Right) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p100/p52 antibody (AP02559PU-S or AP02559PU-N). Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p100/p52 antibody (AP02559PU-S or AP02559PU-N). Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €230.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using NFκB-p100/p52 antibody. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using NFκB-p100/p52 antibody. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

Immunohistochemistry (IHC) analyzes of NFκB-p100/p52 antibody (Cat.-No.: AP06241PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 (1-19) antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Thymus. Rabbit Hu E, ICC/IF, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 pSer872 antibody

Western blot analysis of extracts from RAW264.7 cells treated with EGF using Phospho-NF-κB p100 (Ser872) antibody AP55875PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €340.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 pSer872 antibody

Western blot analysis of extracts from RAW264.7 cells treated with EGF using Phospho-NF-κB p100 (Ser872) antibody AP55875PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
50 µl / €270.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

NFKB2 / NF-kappa-B p100/p52 Rabbit Serum Hu E, IP, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 control peptide

NFKB2 / NF-kappa-B p100/p52 Purified
50 µg / €190.00
  Acris Antibodies GmbH

NFKB2 / NF-kappa-B p100/p52 antibody

NFKB2 / NF-kappa-B p100/p52 Mouse IgG2b 9D2 Hu, Ms, Rt E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

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