NFKBIA / IKBA antibody

Principal name

NFKBIA / IKBA antibody

Alternative names for NFKBIA / IKBA antibody

I-kappa-B-alpha, MAD3, NFKBI, I kappa B-alpha, IkappaBalpha, IkB-alpha, NF-kappa-B inhibitor alpha, Major histocompatibility complex enhancer-binding protein MAD3

SwissProt ID

P25963 (Human), Q08353 (Pig), Q63746 (Rat), Q91974 (Chick), Q9Z1E3 (Mouse)

Gene ID

4792 (NFKBIA), 18035 (Nfkbia)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Sh (Sheep), Mky (Monkey)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Electrophoretic Mobility Shift Assay (EMSA), Flow Cytometry (F)

Background of NFKBIA / IKBA antibody

Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers.Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83.

General readings

1. A. Baldwin, Ann.Rev.Immunol.(1996) 14, 649-681.
2. Hoffmann, A. et al. (2002) The IκB-NFκB Signaling Module: Temporal Control and Selective Gene Activation.
Science 298:8; pp 1241-1245.

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CRISPR

Catalog No. Species Donor Vector  

NFKBIA - human gene knockout kit via CRISPR

NFKBIA - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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