NHEDC2 antibody

Principal name

NHEDC2 antibody

Alternative names for NHEDC2 antibody

NHA2, Mitochondrial sodium / hydrogen exchanger NHA2, Na(+)/H(+) exchanger-like domain-containing protein 2

SwissProt ID

Q5BKR2 (Mouse), Q86UD5 (Human)

Gene ID

133308 (SLC9B2), 97086 (Slc9b2)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of NHEDC2 antibody

The sodium-proton exchangers (NHE) antiporters of the CPA1 family, catalyze + and H+ exchange. NHE activity is also involved in other cellular events such as cell migration, adhesion and proliferation in response to growth factors. Nhedc2 is a novel member of the CPA family and is the first mitochondrial NHA characterized to date. It is also unique in that it is the first eukaryotic and tissue-specific CPA2 characterized to date. Nhedc2 is localized to the mitochondria, where it mediates +-dependent exchanges in mitochondrial PH and + acetate induced mitochondrial passive swelling. It is strongly upregulated during RANKL-induced osteoclast differentiation in vivo and in vitro. R silencing of this gene reduces osteoclast differentiation and resorption, suggesting that it plays a key role(s) in normal osteoclast differentiation and function.

General readings

Battaglino,R.A., (2008) Bone 42 (1), 180-192

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NHEDC2 antibody

  Rabbit Polyclonal anti-Nhedc2 (NHA2) Antibody  
Protein extracts prepared from wild-type mouse bone marrow derived macrophages (BMMs) incubated without (-R, Lane 1, BMMs) or with RANKL (+R, Lane 2, Osteoclasts) were resolved by electrophoresis. The membrane was probed with polyclonal anti-Nhedc2 antibody. Protein was visualized by goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. This antibody recognizes Nhedc2, which runs at approximately 50 kD with predicted molecular weight of 58 kD. Rabbit IgG Poly6485 Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NHEDC2 antibody

  Rabbit Polyclonal Anti-SLC9B2 Antibody  
WB Suggested Anti-SLC9B2 Antibody Titration: 0.2-1 ug/ml; Positive Control: NTERA2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

SLC9B2 - human gene knockout kit via CRISPR

SLC9B2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SLC9B2 - human gene knockout kit via CRISPR

SLC9B2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC9B2 - human gene knockout kit via CRISPR

SLC9B2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC9B2 - human gene knockout kit via CRISPR

SLC9B2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc9b2 - mouse gene knockout kit via CRISPR

Slc9b2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Slc9b2 - mouse gene knockout kit via CRISPR

Slc9b2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc9b2 - mouse gene knockout kit via CRISPR

Slc9b2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc9b2 - mouse gene knockout kit via CRISPR

Slc9b2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC9B2 (mGFP-tagged)-Human Na+/H+ exchanger domain containing 2 (NHEDC2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC9B2 (mGFP-tagged)-Human Na+/H+ exchanger domain containing 2 (NHEDC2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC9B2 (Myc-DDK-tagged)-Human Na+/H+ exchanger domain containing 2 (NHEDC2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC9B2 (Myc-DDK-tagged)-Human Na+/H+ exchanger domain containing 2 (NHEDC2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc9b2 (GFP-tagged) - Mouse Na+/H+ exchanger domain containing 2 (Nhedc2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc9b2 (GFP-tagged) - Mouse Na+/H+ exchanger domain containing 2 (Nhedc2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc9b2 (Myc-DDK-tagged) - Mouse Na+/H+ exchanger domain containing 2 (Nhedc2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc9b2 (Myc-DDK-tagged) - Mouse Na+/H+ exchanger domain containing 2 (Nhedc2), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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