NHLRC1 antibody

Principal name

NHLRC1 antibody

Alternative names for NHLRC1 antibody

EPM2B, NHL repeat-containing protein 1

SwissProt ID

Q6IMG5 (Rat), Q6VVB1 (Human), Q8BR37 (Mouse)

Gene ID

378884 (NHLRC1), 105193 (Nhlrc1), 364682

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of NHLRC1 antibody

Progressive myoclonic epilepsy type 2 (EPM2), also called Lafora disease, is an autosomal recessive disease characterized by grand mal seizures and/or myoclonus at about 15 years of age. Rapid and severe mental deterioration follows, often with psychotic features. Survival is less than 10 years after onset. Starch-like, endoplasmic reticulum-associated polyglucosans, called Lafora bodies, can be observed in brain, muscle, liver and heart. One cause of Lafora disease is due to mutations in NHLRC1, the gene encoding Malin. Forty-nine different mutations in NHLRC1 have been shown to cause EPM2. Malin, also called NHL repeat-containing protein 1  ( NHLRC1), is a single subunit E3 ubiquitin ligase, containing 6 NHL repeats and 1 RING-type zinc finger. Malin’s RING domain is responsible for its ability to mediate ubiquitination. Malin interacts with and polyubiquitinates Laforin, a protein also implicated in EPM2. Malin localizes to the endoplasmic reticulum and, to a lesser extent, in the nucleus. Malin is expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NHLRC1 antibody

Immunoblot against extracts of COS cells transiently transfected with Flag-tagged Malin or untagged Kv2.1 plasmid probed with N85/18 TC supe (left) or rabbit polyclonal (right). Mouse IgG1 N85/18 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

NHLRC1 antibody

Immunoblot against extracts of COS cells transiently transfected with Flag-tagged Malin or untagged Kv2.1 plasmid probed with N85/18 TC supe (left) or rabbit polyclonal (right). Mouse IgG1 N85/18 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

NHLRC1 (N-term) antibody

NHLRC1 Mouse IgG1 S85-18 Purified Hu ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NHLRC1 - human gene knockout kit via CRISPR

NHLRC1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NHLRC1 - human gene knockout kit via CRISPR

NHLRC1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NHLRC1 - human gene knockout kit via CRISPR

NHLRC1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NHLRC1 - human gene knockout kit via CRISPR

NHLRC1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nhlrc1 - mouse gene knockout kit via CRISPR

Nhlrc1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nhlrc1 - mouse gene knockout kit via CRISPR

Nhlrc1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nhlrc1 - mouse gene knockout kit via CRISPR

Nhlrc1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NHLRC1 (mGFP-tagged) - Human NHL repeat containing 1 (NHLRC1), 200 uL, >10^7 TU/mL

Lenti ORF particles, NHLRC1 (mGFP-tagged) - Human NHL repeat containing 1 (NHLRC1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NHLRC1 (Myc-DDK tagged) - Human NHL repeat containing 1 (NHLRC1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, NHLRC1 (Myc-DDK tagged) - Human NHL repeat containing 1 (NHLRC1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Nhlrc1 (GFP-tagged) - Mouse NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nhlrc1 (GFP-tagged) - Mouse NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Nhlrc1 (Myc-DDK-tagged) - Mouse NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nhlrc1 (Myc-DDK-tagged) - Mouse NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Nhlrc1 (GFP-tagged ORF) - Rat NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nhlrc1 (GFP-tagged ORF) - Rat NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Nhlrc1 (Myc-DDK-tagged ORF) - Rat NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nhlrc1 (Myc-DDK-tagged ORF) - Rat NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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