NHLRC1 antibody

Principal name

NHLRC1 antibody

Alternative names for NHLRC1 antibody

EPM2B, NHL repeat-containing protein 1

SwissProt ID

Q6IMG5 (Rat), Q6VVB1 (Human), Q8BR37 (Mouse)

Gene ID

378884 (NHLRC1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of NHLRC1 antibody

Progressive myoclonic epilepsy type 2 (EPM2), also called Lafora disease, is an autosomal recessive disease characterized by grand mal seizures and/or myoclonus at about 15 years of age. Rapid and severe mental deterioration follows, often with psychotic features. Survival is less than 10 years after onset. Starch-like, endoplasmic reticulum-associated polyglucosans, called Lafora bodies, can be observed in brain, muscle, liver and heart. One cause of Lafora disease is due to mutations in NHLRC1, the gene encoding Malin. Forty-nine different mutations in NHLRC1 have been shown to cause EPM2. Malin, also called NHL repeat-containing protein 1  ( NHLRC1), is a single subunit E3 ubiquitin ligase, containing 6 NHL repeats and 1 RING-type zinc finger. Malin’s RING domain is responsible for its ability to mediate ubiquitination. Malin interacts with and polyubiquitinates Laforin, a protein also implicated in EPM2. Malin localizes to the endoplasmic reticulum and, to a lesser extent, in the nucleus. Malin is expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NHLRC1 antibody

Immunoblot against extracts of COS cells transiently transfected with Flag-tagged Malin or untagged Kv2.1 plasmid probed with N85/18 TC supe (left) or rabbit polyclonal (right). Mouse IgG1 N85/18 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

NHLRC1 antibody

Immunoblot against extracts of COS cells transiently transfected with Flag-tagged Malin or untagged Kv2.1 plasmid probed with N85/18 TC supe (left) or rabbit polyclonal (right). Mouse IgG1 N85/18 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

NHLRC1 (N-term) antibody

NHLRC1 Mouse IgG1 S85-18 Purified Hu ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

NHLRC1 antibody

NHLRC1 Mouse IgG2a 3G6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

NHLRC1 antibody

Immunohistochemistry: NHLRC1 Antibody [NBP1-31284] - Immunohistochemical analysis of paraffin-embedded Huh7, using NHLRC1 antibody at 1:100 dilution. Rabbit IgG Hu P
0.1 mg / €340.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NHLRC1

NHLRC1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

NHLRC1

NHLRC1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

7 Item(s)

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