Nicastrin antibody

Principal name

Nicastrin antibody

Alternative names for Nicastrin antibody

NCSTN, KIAA0253, UNQ1874/PRO4317

SwissProt ID

P57716 (Mouse), Q8CGU6 (Rat), Q92542 (Human)

Gene ID

23385 (NCSTN), 289231 (Ncstn)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Nicastrin antibody

Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, γ-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the α and γ cleavage site) or the toxic Aβ amyloid peptide (from the β and γ cleavage site). It is thought that accumulation of the Aβ peptide is the precursor to Alzheimer’s disease. Nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Nicastrin (C-term) antibody

Western blot analysis of Nicastrin in mouse brain tissue lysate with Nicastrin antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

Western blot analysis of Nicastrin in human brain tissue lysate with Nicastrin antibody at (A) 0.5 and (B) 1ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

Western blot analysis of brain cell and C6 cell lysate using NCSTN antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: Jurkat cells, Primary antibody: (NCSTN Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Nicastrin antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cortex. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Nicastrin Control Peptide

Nicastrin
50 µg / €160.00
  Acris Antibodies GmbH

Nicastrin Control Peptide

Nicastrin
50 µg / €160.00
  Acris Antibodies GmbH

Nicastrin antibody

NCSTN polyclonal antibody (A01), Lot # 051214JC01. Western Blot analysis of NCSTN expression in NIH/3T3. Mouse Serum Hu, Ms E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Nicastrin antibody

Western Blot analysis of NCSTN expression in transfected 293T cell line (H00023385-T01) by NCSTN MaxPab polyclonal antibody.

Lane 1: NCSTN transfected lysate(75.79 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Nicastrin antibody

NCSTN MaxPab rabbit polyclonal antibody. Western Blot analysis of NCSTN expression in mouse lung. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Nicastrin antibody

Nicastrin Mouse IgG2a 1E8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Nicastrin antibody

Western blot analysis of mouse brain tissue extracts ( 80 µg ) and probed with NCSTN monoclonal antibody, clone AT3B2 ( Cat # MAB4200 ; 1 : 500 ). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT3B2 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Nicastrin antibody

Immunohistochemistry of NCSTN in human brain tissue with NCSTN polyclonal antibody ( Cat # PAB13231 ) at 5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Nicastrin antibody

Immunohistochemistry of NCSTN in human brain tissue with NCSTN polyclonal antibody ( Cat # PAB13232 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Nicastrin

Nicastrin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Nicastrin

Nicastrin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Nicastrin

Nicastrin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

NCSTN 293T Cell Transient Overexpression Lysate(Denatured)

NCSTN 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

NCSTN overexpression lysate

NCSTN overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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