Nicastrin antibody

Principal name

Nicastrin antibody

Alternative names for Nicastrin antibody

NCSTN, KIAA0253, UNQ1874/PRO4317

SwissProt ID

P57716 (Mouse), Q8CGU6 (Rat), Q92542 (Human)

Gene ID

23385 (NCSTN), 289231 (Ncstn)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Nicastrin antibody

Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, γ-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the α and γ cleavage site) or the toxic Aβ amyloid peptide (from the β and γ cleavage site). It is thought that accumulation of the Aβ peptide is the precursor to Alzheimer’s disease. Nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality.

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Nicastrin (C-term) antibody

  Rabbit Polyclonal Nicastrin Antibody  
Western blot analysis of Nicastrin in mouse brain tissue lysate with Nicastrin antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

  Rabbit Polyclonal Nicastrin Antibody  
Western blot analysis of Nicastrin in human brain tissue lysate with Nicastrin antibody at (A) 0.5 and (B) 1ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

  NCSTN Rabbit Polyclonal Antibody  
Western blot analysis of brain cell and C6 cell lysate using NCSTN antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

  Rabbit Polyclonal Anti-NCSTN Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: Jurkat cells, Primary antibody: (NCSTN Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Nicastrin antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Nicastrin antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cortex. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Nicastrin

  Recombinant protein of human nicastrin (NCSTN)  
Nicastrin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NCSTN overexpression lysate

NCSTN overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NCSTN (mGFP-tagged) - Human nicastrin (NCSTN), 200 uL, >10^7 TU/mL

Lenti ORF particles, NCSTN (mGFP-tagged) - Human nicastrin (NCSTN), 200 uL, >10^7 TU/mL  
200 µl / €1,580.00
  OriGene Technologies, Inc.

Lenti ORF particles, NCSTN (Myc-DDK tagged) - Human nicastrin (NCSTN) , 200 uL, >10^7 TU/mL

Lenti ORF particles, NCSTN (Myc-DDK tagged) - Human nicastrin (NCSTN) , 200 uL, >10^7 TU/mL  
200 µl / €1,420.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ncstn (GFP-tagged ORF) - Rat nicastrin (Ncstn), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ncstn (GFP-tagged ORF) - Rat nicastrin (Ncstn), 200 uL, >10^7 TU/mL  
200 µl / €1,390.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ncstn (Myc-DDK-tagged ORF) - Rat nicastrin (Ncstn), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ncstn (Myc-DDK-tagged ORF) - Rat nicastrin (Ncstn), 200 uL, >10^7 TU/mL  
200 µl / €1,251.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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