NIPP-1 antibody

Principal name

NIPP-1 antibody

Alternative names for NIPP-1 antibody

PPP1R8, ARD1, NIPP1, Nuclear inhibitor of protein phosphatase 1

SwissProt ID

Q12972 (Human), Q28147 (Bovin), Q8R3G1 (Mouse)

Gene ID

5511 (PPP1R8), 100336 (Ppp1r8)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of NIPP-1 antibody

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

General readings

Jin Q., et al. (1999) Biochem. J. 342:13-19Beullens M., et al. (2000) Biochem. J. 352:651-658

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NIPP-1 antibody

  PPP1R8 mouse monoclonal antibody, clone OTI4D5 (formerly 4D5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PPP1R8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804811) Mouse IgG2b OTI4D5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NIPP-1 antibody

  PPP1R8 mouse monoclonal antibody, clone OTI4E5 (formerly 4E5)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-PPP1R8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804812) Mouse IgG1 OTI4E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NIPP-1 antibody

  PPP1R8 mouse monoclonal antibody, clone OTI5H9 (formerly 5H9)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PPP1R8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804813) Mouse IgG1 OTI5H9 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NIPP-1 (C-term) antibody

  Goat Polyclonal Antibody against PPP1R8  
TA302884 staining (2µg/ml) of H460 lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NIPP-1 antibody

  Rabbit polyclonal anti-PPP1R8 antibody  
Western blot analysis of extracts from Jurkat cells, using PPP1R8 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NIPP-1 antibody

  Rabbit Polyclonal Anti-PPP1R8 Antibody  
WB Suggested Anti-PPP1R8 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysatePPP1R8 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NIPP-1 antibody

  Rabbit Polyclonal Anti-PPP1R8 Antibody  
WB Suggested Anti-PPP1R8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: OVCAR-3 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

NIPP-1 antibody

  Rabbit Polyclonal Anti-PPP1R8 Antibody  
WB Suggested Anti-PPP1R8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: 293T cell lysatePPP1R8 is supported by BioGPS gene expression data to be expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NIPP-1 antibody

  Rabbit Polyclonal Anti-PPP1R8 Antibody  
WB Suggested Anti-PPP1R8 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NIPP-1 antibody

  PPP1R8 mouse monoclonal antibody, clone OTI1E2 (formerly 1E2)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R8 (RC210575, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R8. Mouse IgG1 OTI1E2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NIPP-1 antibody

  Purified PPP1R8 mouse monoclonal antibody, clone OTI1E9 (formerly 1E9)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R8 (RC210575, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R8. Mouse IgG1 OTI1E9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NIPP-1 antibody

  PPP1R8 mouse monoclonal antibody, clone OTI2E12 (formerly 2E12)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-PPP1R8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804806) Mouse IgG1 OTI2E12 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NIPP-1 antibody

  PPP1R8 mouse monoclonal antibody, clone OTI2B2 (formerly 2B2)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R8 (RC210575, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R8. Mouse IgG1 OTI2B2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NIPP-1 antibody

Western blot analysis of extracts from Jurkat cells, using PPP1R8 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

NIPP-1 antibody

Western blot analysis of extracts from Jurkat cells, using PPP1R8 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

PPP1R8 - human gene knockout kit via CRISPR

PPP1R8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PPP1R8 - human gene knockout kit via CRISPR

PPP1R8 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PPP1R8 - human gene knockout kit via CRISPR

PPP1R8 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PPP1R8 - human gene knockout kit via CRISPR

PPP1R8 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NIPP-1 (transcript variant 2)

  Recombinant protein of human protein phosphatase 1, regulatory (inhibitor) subunit 8 (PPP1R8), transcript variant 2  
NIPP-1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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