NLRC4 antibody

Principal name

NLRC4 antibody

Alternative names for NLRC4 antibody

CARD12, CLAN, CLAN1, IPAF, NLR family CARD domain-containing protein 4

SwissProt ID

Q9NPP4 (Human)

Gene ID

58484 (NLRC4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of NLRC4 antibody

CARD12, also known as CLAN, IPAF and CLAN1 is a member of the CED4 family of proteins. The CED4/Apaf-1 proteins are critical regulators of apoptosis and NF-kappaB sigling pathways, and CARD12 is no exception. CARD12 has been implicated in coordition of downstream activation of both apoptotic and inflammatory sigling pathways (PMID: 11374873). Additiolly, CARD12 has shown to coprecipitate with caspase 1, an enzyme that participates in both the sigling of apoptosis and cytokine processing, further demonstrating its integral role in programmed cell death (PMID: 11374873). As part of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins, CARD12 is known to be an important regulator of caspase-1 activation via an ATP/dATP nucleotide-binding pocket (PMID: 15882992). CARD12 has four known isoforms. Isoform 1 is highly expressed in lung, followed by leukocytes (especially monocytes), lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Although it is expressed ubiquitously, Isoform 2 is more prominent at the highest levels in lung and spleen. Isoform 4 can only been found in the brain.

General readings

Clark,H.F., et al., (2003) Genome Res. 13 (10), 2265-2270

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NLRC4 antibody

  Rabbit Polyclonal Ipaf Antibody  
Western blot analysis of Ipaf in human PBL lysate with Ipaf antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL, respectively. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NLRC4 antibody

  Rabbit Polyclonal Anti-NLRC4 Antibody  
WB Suggested Anti-NLRC4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

NLRC4 antibody

  Rabbit Polyclonal CARD12 Antibody  
Western Blot: CARD12 Antibody [TA336660] - Western Blot analysis of CLAN in lung lysate with anti-CLAN at a 1:500 dilution. Detects CLAN-A and CLAN-B isoforms. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NLRC4 antibody

  Rabbit Polyclonal CARD12 Antibody  
Immunohistochemistry: CARD12 Antibody [TA336852] - IHC analysis of CARD12 in mouse lung using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NLRC4 antibody

  Rabbit Polyclonal CARD12 Antibody  
Immunohistochemistry: CARD12 Antibody [TA336853] - IHC analysis of CARD12 in mouse lung using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NLRC4 antibody

  Mouse Monoclonal anti-NLRC4 (IPAF) Antibody  
Western blot analysis of THP-1 (lane 1) and 293T (lane2) using anti-NLRC4 antibody (6H9B13). GAPDH (poly6314) was used a loading control. Mouse 6H9B13 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NLRC4 antibody

AP07715PU-N NLRC4 antibody satining of Formalin-Fixed Paraffin-Embedded Human Brain, Cortex at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NLRC4 - human gene knockout kit via CRISPR

NLRC4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NLRC4 - human gene knockout kit via CRISPR

NLRC4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NLRC4 - human gene knockout kit via CRISPR

NLRC4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NLRC4 - human gene knockout kit via CRISPR

NLRC4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NLRC4 overexpression lysate

NLRC4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NLRC4 (mGFP-tagged) - Human NLR family, CARD domain containing 4 (NLRC4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, NLRC4 (mGFP-tagged) - Human NLR family, CARD domain containing 4 (NLRC4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, NLRC4 (Myc-DDK tagged) - Human NLR family, CARD domain containing 4 (NLRC4), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, NLRC4 (Myc-DDK tagged) - Human NLR family, CARD domain containing 4 (NLRC4), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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