NMDA Receptor 1 antibody

Principal name

NMDA Receptor 1 antibody

Alternative names for NMDA Receptor 1 antibody

NMDAR1,GRIN1, Glutamate [NMDA] receptor subunit zeta-1

SwissProt ID

P35438 (Mouse), P35439 (Rat), Q05586 (Human), Q5R1P0 (Canfa)

Gene ID

2902 (GRIN1), 24408 (Grin1), 14810

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Mky (Monkey), Xen (Xenopus)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Dot blot (Dot), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of NMDA Receptor 1 antibody

The NMDA receptors are members of the glutamate receptor family of ion channels that also include the AMPA and Kaite receptors. The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functiol NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit. The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neurol depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels. Ca2+ entry through the NMDAR regulates numerous downstream sigling pathways including long term potentiation (a molecular model of memory) and syptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimerâ??s disease. NMDA receptors expression and function are modulated by a variety of factors including receptor trafficking to the sypses and interlization as well as phosphorylation and interaction with other intracellular proteins.

General readings

Rajji T, Chapman D, Eichenbaum H, Greene R. The role of CA3 hippocampal NMDA receptors in paired associate learning. J Neurosci. 2006 Jan 18;26(3):908-15. PMID: 16421310

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NMDA Receptor 1 (1-564) antibody

Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor. Mouse IgG1 R1JHL Supernatant Ms, Rt C, IP, WB
15 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 (C1 splice variant) antibody

Western blot of 10 ug of HEK 293 cells expressing: Lane 1 - HEK cells without NR1 expression (Mock); Lane 2 - NR1 subunit containing only the C2 Insert; Lane 3 - NR1 subunit containing the C1 and C2' Insert; Lane 4 - NR1 subunit containing the N1 and C2' Insert showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor containing the C1 splice variant insert. Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt C, WB
25 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 (C2 splice variant) antibody

Western blot of 10 ug of HEK 293 cells showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor containing the C2 splice variant insert. Lane 1 - HEK cells without NR1 expression; Lane 2 - NR1 subunit containing only the C2 Insert; Lane 3 - NR1 subunit containing the C1 and C2' insert; Lane 4 - NR1 subunit containing the N1 and C2' insert. Rabbit IgG Aff - Purified Hu, Ms, Rt C, WB
25 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 (N1 splice variant) antibody

Western blot of 10 ug of HEK 293 cells expressing: Lane 1 - NR1 subunit containing the N1 and C2' Insert showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor containing the N1 splice variant insert.; Lane 2 - NR1 subunit containing only the C2 Insert; Lane 3 - NR1 subunit containing the C1 and C2' Insert; Lane 4 - without NR1 expression (Mock). Rabbit IgG Aff - Purified Can, Chk, Hu, Ms, non-Human Primates, Rt, Xen C, WB
25 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 (C2' Splice Variant) antibody

Figure 1. Western blot of 10 µg of HEK 293 cells expressing:  Lane 1: HEK cells without NR1 expression (Mock). Lane 2: NR1 subunit containing only the C2 Insert. Lane 3: NR1 subunit containing the C1 and C2' Insert. Lane 4: NR1 subunit containing the N1 and C2' Insert showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor containing the C2’ splice variant insert. Rabbit IgG Aff - Purified Bov, Hu, Ms, Rt C, WB
25 µg / €380.00
  Acris Antibodies GmbH

NMDA Receptor 1 antibody

TA303128 (2µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Western blot of 10 ug of HEK 293 cells expressing: Lane 1 - HEK cells without NR1 expression (Mock); Lane 2 - NR1 subunit containing only the C2 Insert; Lane 3 - NR1 subunit containing the C1 and C2' Insert; Lane 4 - NR1 subunit containing the N1 and C2' Insert showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor containing the C2’ splice variant insert. Rabbit IgG Purified Ms, Rt P, WB
25 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Anti-GRIN1 / NMDAR1 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit IgG Purified Hu, Ms, Rt E
50 µg / €345.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and esophagus cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using GRIN1 antibody at dilution 1/45, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using GRIN1 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 (42-361, Extracell. Dom.) antibody

Western blot analysis of GluN1-NR1 in rat brain membrane tissues, using a 1:1000 dilution of the antibody Mouse IgG1 S308-48 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Western blot analysis of NMDAR1 expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Western blot analysis of NMDAR1 expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Western blot analysis of rat brain lysate: 1. Anti-NMDA Receptor 1 (GluN1) (extracellular) antibody, (1:600). 2. Anti-NMDA Receptor 1 (GluN1) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NMDA Receptor 1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 N308/48 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

NMDA Receptor 1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 N308/48 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

NMDA Receptor 1 pSer896 antibody

Figure 1. Western blot analysis of extract from MCF7 cells, untreated or treated with estradiol (100 nM, 20 min), using NMDAR1 (phospho-Ser896) antibody (AP02396PU). Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €320.00
  Acris Antibodies GmbH

NMDA Receptor 1 pSer896 antibody

Figure 1. Western blot analysis of extract from MCF7 cells, untreated or treated with estradiol (100 nM, 20 min), using NMDAR1 (phospho-Ser896) antibody (AP02396PU). Rabbit Aff - Purified Hu, Ms WB
50 µl / €240.00
  Acris Antibodies GmbH

NMDA Receptor 1 (C2 splice variant) antibody

NMDA Receptor 1 Rabbit IgG Purified Hu, Ms, Rt WB
25 µg / €510.00
  Acris Antibodies GmbH

NMDA Receptor 1 (N1 splice variant) antibody

NMDA Receptor 1 Rabbit IgG Purified Can, Chk, Hu, Mky, Ms, Rt, Xen WB
25 µg / €500.00
  Acris Antibodies GmbH

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