NMDA Receptor 2A antibody

Principal name

NMDA Receptor 2A antibody

Alternative names for NMDA Receptor 2A antibody

NMDAR2A, GRIN2A, NR2A, Glutamate [NMDA] Receptor subunit epsilon-1

SwissProt ID

P35436 (Mouse), Q00959 (Rat), Q12879 (Human)

Gene ID

2903 (GRIN2A), 24409 (Grin2a), 14811

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Frog, Rb (Rabbit), Fi (Fish), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of NMDA Receptor 2A antibody

The NMDA receptors are members of the glutamate receptor family of ion channels that also include the AMPA and Kaite receptors. The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functiol NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit. The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neurol depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels. Ca2+ entry through the NMDAR regulates numerous downstream sigling pathways including long term potentiation (a molecular model of memory) and syptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimerâ??s disease. NMDA receptors expression and function are modulated by a variety of factors including receptor trafficking to the sypses and interlization as well as phosphorylation and interaction with other intracellular proteins.

General readings

Endele, S., et al. Nat. Genet. 42(11):1021-1026(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010)
King, J.E., et al. Am. J. Pathol. 176(6):2819-2830(2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NMDA Receptor 2A (C-term) antibody

Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~180k NR2A subunit of the NMDA receptor. Rabbit IgG Aff - Purified Hu, Ms, Rt C, IP, WB
10 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2A antibody

Western blot analysis of rat brain lysates: 1. Anti-NMDA Receptor 2A (GluN2A) (extracellular) antibody, (1:600). 2. Anti-NMDA Receptor 2A (GluN2A) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NMDA Receptor 2A (C-term) antibody

Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2A subunit of the NMDA receptor. Rabbit IgG Serum Hu, Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2A (N-term) antibody

Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2A subunit of the NMDA receptor. Rabbit IgG Aff - Purified Bov, Ms, Rt C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2A (75-325, Extracell. Dom.) antibody

NMDA Receptor 2A Mouse IgG2a S327-95 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2A antibody

NMDA Receptor 2A Mouse IgG2b S327A-38 Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2A antibody

WB Suggested Anti-GRIN2A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2A antibody

Adult rat hippocampus immunohistochemstry Mouse IgG2a N327/95 Supernatant Hu, Ms, Rt C, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

NMDA Receptor 2A antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged NR2A, NR2B or untagged Kv2.1 plasmid and probed with N327A/38 (left) and N86/38 (right) TC supe. Mouse IgG2b N327A/38 Supernatant Hu, Ms, Rt C, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

NMDA Receptor 2A antibody

Adult rat hippocampus immunohistochemstry Mouse IgG2a N327/95 Purified Hu, Ms, Rt C, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

NMDA Receptor 2A (875-885) antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Hst, Hu, Mky, Ms, Op, Platypus, Prim, Rt, Tr, Xen P
50 µg / €470.00
  Acris Antibodies GmbH

NMDA Receptor 2A (C-term) antibody

Immunostaining of rabbit retina showing NR2A in the rod and cone photoreceptors in the outer plexiform layer as well as the entire inner plexiform layer. Rabbit Ig Aff - Purified Hu, Ms, Rt IP, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

NMDA Receptor 2A pTyr1325 antibody

Western blot of Rat hippocampal lysate showing specific immunolabeling of the ~180k NR2A subunit of the NMDAR phosphorylated at Tyr1325 (Control). The phosphospecificity of this labeling is shown in the second lane where immunoreactivity is blocked by preadsorption with the phospho-peptide (Peptide) used as antigen but not by the dephosphopeptide (not shown). Rabbit IgG Aff - Purified Ms, Rt WB
0.1 ml / €380.00
  Acris Antibodies GmbH

NMDA Receptor 2A (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with NMDA Receptor 2A Antibody (Center) Cat.-No AP51952PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

NMDA Receptor 2A (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue reacted with NMDA Receptor 2A Antibody (C-term) Cat.-No AP51953PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

NMDA Receptor 2A antibody

Western blot of 10 µg of rat hippocampal lysate showing specific immunolabeling of the ~180k Grin2a subunit of the NMDA receptor. Using Grin2a polyclonal antibody ( Cat # PAB9635 ). Rabbit Bov, Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

NMDA Receptor 2A antibody

Western blot of 10 µg of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~180k Grin2a subunit of the NMDA receptor. Using Grin2a polyclonal antibody ( Cat # PAB9699 ). Rabbit Hu, Ms, Rt C, IP, WB
10 µg / €470.00
  Abnova Taiwan Corp.

NMDA Receptor 2A pTyr1246/1252 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using NMDAR2A/B (Phospho-Tyr1246/1252) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

NMDA Receptor 2A pTyr1246/1252 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using NMDAR2A/B (Phospho-Tyr1246/1252) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

NMDA Receptor 2A antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using NMDAR2A/B (Ab-1246/1252) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

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