NMDA Receptor 2C antibody

Principal name

NMDA Receptor 2C antibody

Alternative names for NMDA Receptor 2C antibody

GRIN2C, NMDAR2C, NR2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C

SwissProt ID

Q00961 (Rat), Q01098 (Mouse), Q14957 (Human)

Gene ID

24411 (Grin2c), 2905 (GRIN2C), 14813

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Dros (Drosophila), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of NMDA Receptor 2C antibody

The NMDA receptors (NMDARs) are members of the glutamate receptor family of ion channels that also include the AMPA and Kaite receptors. The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functiol NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit. The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neurol depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels. NMDA are generally highly expressed in the central nervous system, particularly in the brain. In addition, NMDAR2C has been also detected in the heart, sketeletal muscle, and pancreas. Ca2+ entry through the NMDAR regulates numerous downstream sigling pathways including long term potentiation (a molecular model of memory) and syptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinsonâ??s and Alzheimerâ??s disease. The expression and function of NMDA receptors are modulated by a variety of factors including receptor trafficking to the sypses and interlization as well as phosphorylation and interaction with other intracellular proteins.

General readings

Self,R.L., et al., (2004) Brain Res. 995 (1), 39-45

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NMDA Receptor 2C (N-term) antibody

  Rabbit Anti-NMDA NR2C Subunit Antibody  
Western blot of 10 ug of rat cerebellar lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor. Rabbit IgG Aff - Purified Hu, Ms, Rt IP, WB
10 µg / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2C antibody

  Rabbit Anti-NMDA NR2C Subunit (Ser1096) Antibody (Phospho-Specific)  
Western blot of mouse brain lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1096. The phosphospecificity is shown in the second lane where immunoreactivity is blocked by preadsorption with the phospho-peptide (Peptide) used as antigen but not by the dephosphopeptide (not shown). Rabbit IgG Purified Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2C antibody

  Rabbit Anti-NMDA NR2C Subunit (Ser1244) Antibody (Phospho-Specific)  
Western blot of rat cerebellum lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1244. The phosphospecificity is shown in the second lane where immunoreactivity is blocked by preadsorption with the phospho-peptide (Peptide) used as antigen but not by the dephosphopeptide (not shown). Rabbit IgG Purified Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2C antibody

  Anti-GRIN2C Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus, Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using GRIN2C antibody at dilution 1/100, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2C antibody

  Anti-GRIN2C Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human ovarian cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using GRIN2C antibody at dilution 1/80, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDA Receptor 2C antibody

  Rabbit Polyclonal Anti-NMDA Receptor 2C (GluN2C) (extracellular)  
Western blot analysis of rat brain membrane: 1. Anti-NMDA Receptor 2C (GluN2C) (extracellular) antibody, (1:200). 2. Anti-NMDA Receptor 2C (GluN2C) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NMDA Receptor 2C antibody

  Rabbit Polyclonal Anti-GRIN2C Antibody  
WB Suggested Anti-GRIN2C Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate GRIN2C is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

GRIN2C - human gene knockout kit via CRISPR

GRIN2C - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GRIN2C - human gene knockout kit via CRISPR

GRIN2C - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRIN2C - human gene knockout kit via CRISPR

GRIN2C - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRIN2C - human gene knockout kit via CRISPR

GRIN2C - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grin2c - mouse gene knockout kit via CRISPR

Grin2c - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Grin2c - mouse gene knockout kit via CRISPR

Grin2c - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grin2c - mouse gene knockout kit via CRISPR

Grin2c - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grin2c - mouse gene knockout kit via CRISPR

Grin2c - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grin2c (GFP-tagged) - Mouse glutamate receptor, ionotropic, NMDA2C (epsilon 3) (Grin2c), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grin2c (GFP-tagged) - Mouse glutamate receptor, ionotropic, NMDA2C (epsilon 3) (Grin2c), 200 uL, >10^7 TU/mL  
200 µl / €2,100.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grin2c (Myc-DDK-tagged) - Mouse glutamate receptor, ionotropic, NMDA2C (epsilon 3) (Grin2c), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grin2c (Myc-DDK-tagged) - Mouse glutamate receptor, ionotropic, NMDA2C (epsilon 3) (Grin2c), 200 uL, >10^7 TU/mL  
200 µl / €1,890.00
  OriGene Technologies, Inc.

17 Item(s)

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