NMDAR2B antibody

Principal name

NMDAR2B antibody

Alternative names for NMDAR2B antibody

GRIN2B, NMDA Receptor 2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3

SwissProt ID

Q00960 (Rat), Q01097 (Mouse), Q13224 (Human)

Gene ID

2904 (GRIN2B), 24410 (Grin2b), 14812

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Rb (Rabbit), Bov (Bovine), Chk (Chicken), Can (Canine), Ze (Zebrafish), Xen (Xenopus), African clawed frog, Prim (Primate)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P)

Background of NMDAR2B antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
NR2B containing receptors have been implicated in synaptic plasticity, memory formation and pain modulation (3). Studies suggest that the NR2B subunit of glutamate receptors may be potential targets for relieving pain; NR2B may be a probable target for anti-nociceptive drugs, and may also be useful as analgesics (4).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NMDAR2B (C-term) antibody

  Rabbit Anti-NMDA NR2B Subunit Antibody  
Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDA receptor. Rabbit IgG Aff - Purified Hu, Ms, Rt C, IP, WB
10 µg / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Polyclonal Anti-NMDA Receptor 2B (GluN2B) (extracellular)  
Western blot analysis of rat brain lysates: 1. Anti-NMDA Receptor 2B (GluN2B) (extracellular) antibody, (1:600). 2. Anti-NMDA Receptor 2B (GluN2B) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NMDAR2B antibody

immunoblot against rat brain membranes (RBM) and neuronal lysates from NR2B knockout (KO) and heterozygote (Het) mice. Samples courtesy of Ben Hall and Anirvan Ghosh (UCSD Mouse IgG2b N59/36 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

NMDAR2B antibody

Immunoblot against rat brain membranes (RBM) and neuronal lysates from NR2B knockout (KO) and heterozygote (Het) mice. Samples courtesy of Ben Hall and Anirvan Ghosh (UCSD). Mouse IgG2b N59/36 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

NMDAR2B antibody

  Goat Polyclonal Antibody against GRIN2B  
TA303120 (2µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NMDAR2B (C-term) antibody

  Rabbit Anti-NMDA NR2B Subunit Antibody  
Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDA receptor. Rabbit IgG Serum Hu, Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

NMDAR2B (N-term) antibody

  Rabbit Polyclonal Anti-NMDA NR2B Subunit, N-terminus Antibody  
Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDA receptor. Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Anti-NMDA NR2B Subunit (Tyr1252) Antibody (Phospho-Specific)  
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDAR phosphorylated at Tyr1252 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the phospho-Tyr1252 NMDA NR2B subunit antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase. Rabbit IgG Purified Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Anti-NMDA NR2B Subunit (Tyr1336) Antibody (Phospho-Specific)  
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDAR phosphorylated at Tyr1336 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the phospho-Tyr1336 NMDA NR2B antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase. Rabbit IgG Purified Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Anti-NMDA NR2B Subunit (Tyr1472) Antibody (Phospho-Specific)  
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDAR phosphorylated at Tyr1472 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the phospho-Tyr1472 NMDA NR2B antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase. Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Anti-NMDA NR2B Subunit (Ser1480) Antibody (Phospho-Specific)  
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDAR phosphorylated at Ser1480 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the phospho-Ser1480 NMDA NR2B subunit antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase. Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B (N-term) antibody

  Mouse Monoclonal anti-NR2B Antibody  
Western blot analysis of NR2B in rat brain membrane lysates using a 1:1000 dilution of TA309447. Mouse IgG2a S59-20 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NMDAR2B (N-term) antibody

  Mouse Monoclonal anti-NR2B Antibody  
Western blot analysis of NR2B in rat brain membrane lysates using a 1:1000 dilution of TA309448. Mouse IgG2b S59-36 Purified Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit polyclonal GRIN2B(Ab-1303) antibody  
Western blot analysis of extracts from mouse brain cells, using GRIN2B(Ab-1303) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit polyclonal NMDAR2B (Tyr1336) antibody(Phospho-specific)  
Western blot analysis of extracts from Jurkat cells, treated with TNF (20ng/ml, 30mins), using NMDAR2B (Phospho-Tyr1336) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Anti-GRIN2B Rabbit Polyclonal Antibody  
Predicted band size: 166 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 40 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Polyclonal NMDAR2B Antibody  
Western blot analysis of NMDAR2B expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Polyclonal NMDAR2B Antibody  
Western blot analysis of NMDAR2B expression in A549 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Polyclonal NMDAR2B (Tyr1336) Antibody (Phospho-specific)  
Western blot analysis of NMDAR2B phosphorylation expression in TNF treated Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2B antibody

  Rabbit Polyclonal NMDAR2B (Tyr1474) Antibody (Phospho-specific)  
Western blot analysis of NMDAR2B phosphorylation expression in UV treated Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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