NMDAR2D antibody

Principal name

NMDAR2D antibody

Alternative names for NMDAR2D antibody

NR2D, GRIN2D, NMDAR2D, Glutamate [NMDA] receptor subunit epsilon-4, N-methyl D-aspartate receptor subtype 2D

SwissProt ID

O15399 (Human), Q03391 (Mouse), Q62645 (Rat)

Gene ID

2906 (GRIN2D), 24412 (Grin2d)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P)

Background of NMDAR2D antibody

The NMDA receptors (NMDARs) are members of the glutamate receptor family of ion channels that also include the AMPA and Kaite receptors. The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functiol NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit. The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neurol depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels. Ca2+ entry through the NMDAR regulates numerous downstream sigling pathways including long term potentiation (a molecular model of memory) and syptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinsonâ??s and Alzheimerâ??s disease. The expression and function of NMDA receptors are modulated by a variety of factors including receptor trafficking to the sypses and interlization as well as phosphorylation and interaction with other intracellular proteins.

15 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NMDAR2D antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and ovarian cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human breast and ovarian cancer tissue using GRIN2D antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2D antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and ovarian cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human breast and ovarian cancer tissue using GRIN2D antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NMDAR2D antibody

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain membranes: 1. Anti-NMDA Receptor 2D (GluN2D) (extracellular) antibody, (1:200). 2. Anti-NMDA Receptor 2D (GluN2D) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NMDAR2D antibody

ELISA: NMDAR2D Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

NMDAR2D antibody

Western blot (WB) analysis of NMDAε4 antibody (Cat.-No.: AP21181PU-N) in extracts from COS-7 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NMDAR2D antibody

NMDAR2D Goat Hu, Ms, Rt E
0.1 mg / €390.00
  Abnova Taiwan Corp.

NMDAR2D antibody

Western blot analysis of extracts from COS7 cells, using GRIN2D Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

NMDAR2D antibody

Western blot analysis of extracts from COS7 cells, using GRIN2D Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

NMDAR2D antibody

Western blot analysis of NMDAR2D expression in HEK293T (A); HepG2 (B) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

NMDAR2D antibody

Western blot analysis of NMDAR2D expression in HEK293T (A); HepG2 (B) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

NMDAR2D antibody

Western blot analysis of NMDAR2D expression in HEK293T (A); HepG2 (B) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

NMDAR2D antibody

ELISA: NMDAR2D Antibody [36340002] Rabbit Hu E, WB
50 µg / €400.00
  Novus Biologicals Inc.

NMDAR2D antibody

NMDAR2D Rabbit Purified Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

NMDAR2D antibody

NMDAR2D Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

NMDAR2D antibody

NMDAR2D Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
50 µg / €290.00
  Novus Biologicals Inc.

15 Item(s)

per page
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