NOBOX antibody

Principal name

NOBOX antibody

Alternative names for NOBOX antibody

Homeobox protein NOBOX

SwissProt ID

O60393, Q8VIH1

Gene ID

18291 (Nobox), 135935 (NOBOX)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of NOBOX antibody

Early ovarian folliculogenesis is characterized by the breakdown of germ cell clusters and formation of primordial follicles. The cessation of ovarian function under the age of 40 years results in premature ovarian failure (POF) and is accompanied by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. 1% of all women are affected by POF, and mutations in a few genes, including inhibin? fsh receptor and the LH/choriogonadotropin receptor have been linked to POF. In addition, several germ cell specific genes and downstream transcription factors are thought to play and important role in human oogenesis. NOBOX (newborn ovary homeobox gene), an ooctye-specific homeobox gene, is a critical protein involved in early folliculogenesis. Missense mutations have been shown to cause nonsyndromic ovarian failure by disrupting the NOBOX proteins ability to bind to NOBOX DNA-binding element (NBE), and thereby inhibiting its regulation of Pou5f1 and GDF-9. NOBOX expression in the ovary is oocyte specific, but it shows expression in adult testis and pancreas as well.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOBOX antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-NOBOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808379)(1:150) Mouse IgG1 OTI4C5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NOBOX antibody

WB Suggested Anti-Nobox Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Mouse Muscle Rabbit IgG Purified Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

NOBOX antibody

WB Suggested Anti-NOBOX Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

NOBOX antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NOBOX mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA808449)(1:150) Mouse IgG1 OTI8C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NOBOX antibody

NOBOX Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

NOBOX (Center) antibody

Mouse Muscle; WB Suggested Anti-Nobox Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Mouse Muscle; Nobox antibody - middle region (ARP37450_P050) in Mouse Muscle cells using Western Blot Rabbit Aff - Purified Ms WB
50 µg / €350.00
  AVIVA Systems Biology

Lysates

Catalog No.    

NOBOX overexpression lysate

NOBOX overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

7 Item(s)

per page
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