Noggin antibody

Principal name

Noggin antibody

Alternative names for Noggin antibody

NOG

SwissProt ID

P97466 (Mouse), Q13253 (Human), Q62809 (Rat)

Gene ID

9241 (NOG), 18121 (Nog)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Can (Canine), Bov (Bovine), Por (Porcine), Sh (Sheep)

Available hosts

Goat, Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP)

Background of Noggin antibody

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Bachiller, D., Klingensmith, J., Kemp, C., Belo, J. A., Anderson, R. M., May, S. R., McMahon, J. A., McMahon, A. P., Harland, R. M., Rossant, J. and De Robertis, E. M. The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403: 658-661, 2000.
2. Valenzuela, D.M., Economides, A.N., Rojas, E., Lamb, T.M., Nunez, L., Jones, P., Ip ,N.Y., Espinosa, R. III, Brannan, C.I., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Le Beau, M.M., Harland, R.M., and Yancopoulos,G.D.,
Identification of mammalian noggin and its expression in the adult nervous system. (1995) J. Neurosci. 15:6077-6084.
3. Gong, Y., Krakow, D., Marcelino, J., Wilkin, D., Chitayat, D., Babul-Hirji, R., Hudgins, L., Cremers, C.W., Cremers, F.P.M., Brunner, H.G., Reinker, K., Rimoin, D.L., Cohn, D.H., Goodman, F.R., Reardon, W., Patton, M., Francomano, C.A., and Warman,M.L., Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. (1999) Nat. Genet. 21:302-304

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Noggin antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-Nog mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500028) Mouse IgG2b OTI4C12 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Noggin antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-Nog mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500029) Mouse IgG2b OTI1H8 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Noggin antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of lung using anti-Nog (TA500116) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min). Mouse IgG2b OTI1C1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Noggin antibody

NOG MaxPab rabbit polyclonal antibody. Western Blot analysis of NOG expression in human liver. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Noggin antibody

Western Blot: Noggin Antibody [TA336497] 20ug of human hippocampus tissue lysate (lanes 2 and 4) with Noggin polyclonal at 1:1000 dilution followed by secondary at 1:5000 dilution MW marker Lane 1 peptide absorption control lane 3. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Noggin antibody

Western Blot: Noggin Antibody [TA336514] - Western blot detection of Noggin in 20 ug of human hippocampus tissue lysate (lanes 2 and 4) with Noggin polyclonal at 1:1000 dilution followed by AP-conjugated secondary at 1:5000 dilution. MW marker lane 1. Pep Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Noggin antibody

WB Suggested Anti-NOG Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Noggin antibody

Western blot detection of Noggin in CHO-K1 cell lysates over-expressing Noggin-PDGFR transmembrane domain fused protein using Noggin mouse mAb (1:1000 diluted).Predicted band size:26KDa.Observed band size:37KDa. Mouse IgG3 1D2-G8-G1 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Noggin antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Noggin antibody

Western Blot analysis of NOG expression in transfected 293T cell line (H00009241-T01) by NOG MaxPab polyclonal antibody.

Lane 1: NOG transfected lysate(25.52 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Noggin antibody

NOG MaxPab rabbit polyclonal antibody. Western Blot analysis of NOG expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Noggin antibody

Noggin Mouse IgG2b 4C9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Noggin antibody

Noggin Mouse IgG2a 3A2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Noggin antibody

Noggin Mouse IgG2b 4A1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Noggin antibody

Noggin Mouse IgG2a 2E10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Noggin antibody

Noggin Mouse IgG2b 2C10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Noggin antibody

Western blot analysis of NOG in 20 µg of human hippocampus tissue lysate ( Lanes 2 and 4 ) with NOG polyclonal antibody at 1 : 1000 dilution ( Cat# PAB12096 ). Lane1 : MW marker, Lane3 : control. Rabbit Hu, Ms, Rt WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Noggin (Center) antibody

Human ACHN; WB Suggested Anti-NOG Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: ACHN cell lysate; NOG antibody - middle region (ARP58773_P050) in Human ACHN cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Noggin antibody

Noggin staining of Cardiac Tissue of 11 d.p.c. Mouse Embryos. Tissue was stained with goat HRP-DAB  (brown) and  counterstained with Hematoxylin (blue). Goat Aff - Purified Ms C, E, ICC/IF, WB
0.1 mg / €450.00
  Neuromics Antibodies

Noggin antibody

Noggin Rabbit IgG Hu, Ms, Rt E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

Items 1 to 20 of 38 total

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