Nogo 66 receptor antibody

Principal name

Nogo 66 receptor antibody

Alternative names for Nogo 66 receptor antibody

Reticulon-4 receptor, Nogo receptor, RTN4R, NOGOR

SwissProt ID

Q99M75 (Rat), Q99PI8 (Mouse), Q9BZR6 (Human)

Gene ID

65078 (RTN4R), 65079 (Rtn4r), 113912

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Goat, Rabbit, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Nogo 66 receptor antibody

The Nogo receptor is a leucine-rich repeat (LRR) containing protein with a glycosylphosphatidylinositol (GPI) anchored C-terminus. The receptor was identified on the basis of its ability to bind with high affinity to Nogo-A a member of the reticulon family expressed in the cell membrane of oligodendrocytes. Nogo-A attracted attention when it was demonstrated that it is a myelin protein capable of inhibiting axol growth following nerve injury. Other myelin proteins also identified as axol growth inhibitors are the myelin-associated glycoprotein (MAG) a sialic-dependent immunoglobulin-like family member lectin (SIGLEC) and the oligodendrocyte myelin glycoprotein (OmgP) which is a GPI-anchored membrane protein. Remarkably, despite their structural diversity, all three axol growth inhibitors bind to the Nogo receptor with high affinity. Since the Nogo receptor is a GPI-anchored protein it was expected that it would require another protein component to transduce the Nogo-A binding information into the responding neurons interior. Indeed, it was shown that the neurotrophin receptor p75 (p75NTR) interacts with Nogo receptor and a third protein termed LINGO-1 to mediate axol growth inhibition sigling. We are pleased to offer a new antibody directed against a highly conserved epitope situated in the linker region between the LRRs and the GPI anchor. The antibody will work with human, mouse and rat samples and has been tested in western blot, immunocytochemistry and immunohistochemistry techniques.

General readings

Shao Z, Browning JL, Lee X, Scott ML, Shulga-Morskaya S, Allaire N, Thill G, Levesque M, Sah D, McCoy JM, Murray B, Jung V, Pepinsky RB, Mi S. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron. 2005 Feb 3;45(3):353-9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Nogo 66 receptor antibody

  Goat Polyclonal Antibody against Nogo 66 receptor  
TA302551 (0.3µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide.  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nogo 66 receptor antibody

  Rabbit Polyclonal Anti-Nogo Receptor  
Western blot analysis of rat brain lysate: 1. Anti-Nogo Receptor (extracellular) antibody, (1:200). 2. Anti-Nogo Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Nogo 66 receptor antibody

  Rabbit anti-RTN4R Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using RTN4R antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nogo 66 receptor antibody

  Rabbit Polyclonal Anti-RTN4R Antibody  
Nogo 66 receptor Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Nogo 66 receptor antibody

Nogo 66 receptor Rat IgG2 3D66 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Nogo 66 receptor (27-447) antibody

Nogo Receptor staining in sections of paraffin-embedded human spinal cord. Tissues were stained with anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue). Goat Aff - Purified Hu E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

RTN4R - human gene knockout kit via CRISPR

RTN4R - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RTN4R - human gene knockout kit via CRISPR

RTN4R - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RTN4R - human gene knockout kit via CRISPR

RTN4R - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RTN4R - human gene knockout kit via CRISPR

RTN4R - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rtn4r - mouse gene knockout kit via CRISPR

Rtn4r - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Rtn4r - mouse gene knockout kit via CRISPR

Rtn4r - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rtn4r - mouse gene knockout kit via CRISPR

Rtn4r - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rtn4r - mouse gene knockout kit via CRISPR

Rtn4r - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Nogo 66 receptor

  Recombinant protein of human reticulon 4 receptor (RTN4R)  
Nogo 66 receptor Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €399.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

RTN4R overexpression lysate

RTN4R overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, RTN4R (mGFP-tagged) - Human reticulon 4 receptor (RTN4R), 200 uL, >10^7 TU/mL

Lenti ORF particles, RTN4R (mGFP-tagged) - Human reticulon 4 receptor (RTN4R), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, RTN4R (Myc-DDK tagged) - Human reticulon 4 receptor (RTN4R) , 200 uL, >10^7 TU/mL

Lenti ORF particles, RTN4R (Myc-DDK tagged) - Human reticulon 4 receptor (RTN4R) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Rtn4r (GFP-tagged) - Mouse reticulon 4 receptor (Rtn4r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn4r (GFP-tagged) - Mouse reticulon 4 receptor (Rtn4r), 200 uL, >10^7 TU/mL  
200 µl / €1,080.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rtn4r (Myc-DDK-tagged) - Mouse reticulon 4 receptor (Rtn4r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn4r (Myc-DDK-tagged) - Mouse reticulon 4 receptor (Rtn4r), 200 uL, >10^7 TU/mL  
200 µl / €970.00
  OriGene Technologies, Inc.

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