NOL3 / ARC antibody

Principal name

NOL3 / ARC antibody

Alternative names for NOL3 / ARC antibody

Nucleolar protein 3, NOP, Myp, Nop30, Nucleolar protein of 30 kDa, Muscle-enriched cytoplasmic protein, Apoptosis repressor with CARD

SwissProt ID

O60936 (Human), O60936-2, Q62881 (Rat), Q9D1X0 (Mouse)

Gene ID

8996 (NOL3), 85383 (Nol3), 78688

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of NOL3 / ARC antibody

NOL3(Nucleolar protein 3), also known as ARC, NOP30, CARD2 and MYP, is a protein that in humans is encoded by the NOL3 gene. NOL3 has been shown to interact with SFRS9 and Caspase 8. By genomic sequence analysis, Stoss et al. (1999) determined that the NOL3 gene, which encodes NOP30 and MYP and which they called NOP, is composed of 4 exons. The alternative 5-prime splice site that generates the 2 isoforms is located in exon 2. It is reported that expression of the ARC cDNA encoding the smaller transcript inhibited apoptosis in a dose-dependent manner when coexpressed with CASP8 but not when coexpressed with CASP9. ARC also inhibited apoptosis induced by stimulation of CD95/FAS, tumor necrosis factor receptor-1, and TRAMP/death receptor-3. Enzymatic analysis showed that ARC inhibits the enzymatic activity of CASP8. Immunoprecipitation and immunoblot analysis indicated that ARC interacts with CASP2 and CASP8 through its N-terminal death effector domain but does not interact with CASP1, CASP3, or CASP9.

General readings

1. Abmayr, S., Crawford, R. W., Chamberlain, J. S.Characterization of ARC, apoptosis repressor
interacting with CARD, in normal and dystrophin-deficient skeletal muscle.Hum. Molec. Genet. 13:
213-221, 2004.
2. Koseki, T., Inohara, N., Chen, S., Nunez, G.ARC, an inhibitor of apoptosis expressed in skeletal
muscle and heart that interacts selectively with caspases.Proc. Nat. Acad. Sci. 95: 5156-5160, 1998.
3. Stoss, O., Schwaiger, F.-W., Cooper, T. A., Stamm, S.Alternative splicing determines the intracellular
localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c.J. Biol.
Chem. 274: 10951-10962, 1999.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOL3 / ARC (C-term) antibody

  Rabbit Polyclonal ARC Antibody  
Western blot analysis of ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with ARC antibody at 1:1000 dilution. 1st Below: Immunohistochemistry of ARC in human heart tissue at 5 µg/ml. 2nd Below: Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 µg/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC (N-term) antibody

  Rabbit Polyclonal ARC Antibody  
Western blot analysis of ARC in HeLa whole cell lysates with ARC antibody at 1:500 dilution. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC antibody

  Rabbit Polyclonal Nop30 Antibody  
Western blot analysis of Nop30 in mouse muscle tissue lysate with Nop30 antibody at (A) 0.5, (B) 1 and (C) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC antibody

  Rabbit polyclonal anti-NOL3 / ARC antibody  
Western blot analysis of extracts from HeLa cells, using ARC antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC antibody

  Rabbit Polyclonal Anti-NOL3 Antibody  
WB Suggested Anti-NOL3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Muscle Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC antibody

  Rabbit Polyclonal ARC/NOL3 Antibody  
Western Blot: NOL3 Antibody [TA336665] - Analysis of TA336665 at 1:1000 dilution. Lane 1: NIH3T3 cells. Lane 2: NIH3T3 cells transfected with NOL3. Lane 3: Recombinant ARC. Lane 4: Recombinant NOL3. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC antibody

  Rabbit Polyclonal Anti-ARC Antibody  
Western blot analysis on HeLa cell lysate using ARC Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC antibody

  Rabbit Polyclonal Anti-NOL3 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using (NOL3 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOL3 / ARC antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ARC Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €230.00
  Assay Biotech

NOL3 / ARC antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ARC Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €330.00
  Assay Biotech

NOL3 / ARC Control Peptide

NOL3 / ARC Liquid
0.1 mg / €170.00
  Neuromics Antibodies

NOL3 / ARC antibody

NOL3 / ARC Rabbit Purified Hu ICC/IF, WB
50 µl / €230.00
  Neuromics Antibodies

NOL3 / ARC (isoform 2) antibody

NOL3 / ARC Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €460.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

NOL3 - human gene knockout kit via CRISPR

NOL3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NOL3 - human gene knockout kit via CRISPR

NOL3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOL3 - human gene knockout kit via CRISPR

NOL3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOL3 - human gene knockout kit via CRISPR

NOL3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NOL3 / ARC

  Recombinant protein of human nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3)  
NOL3 / ARC Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

NOL3 / ARC (transcript variant 3)

  Recombinant protein of human nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), transcript variant 3.  
NOL3 / ARC Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

NOL3 / ARC (1-208, His-tag)

NOL3 / ARC Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

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