Norepinephrine Transporter antibody

Principal name

Norepinephrine Transporter antibody

Alternative names for Norepinephrine Transporter antibody

Slc6a2, Sodium-dependent noradrenaline transporter, NET, Solute carrier family 6 member 2

SwissProt ID

O55192 (Mouse), P23975 (Human), P51143 (Bovin)

Gene ID

6530 (SLC6A2), 20538

Available reactivities

Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Chk (Chicken), Hu (Human), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Dot blot (Dot), Enzyme Immunoassay (E), Frozen Sections (C)

Background of Norepinephrine Transporter antibody

Many physiological, endocrine and behavioral functions are determined and regulated by monoamine sigling. Many brain disorders such as depression, drug abuse, schizophrenia, attention deficit hyperactivity disorder (ADHD) are caused by the malfunction of monoaminergic transmission. The intensity of monoaminergic sigling is determined by the availability of the monoamine, which is in turn determined in part by its uptake from the extracellular milieu via monoamine transporters. These transporters include DAT, SERT, and NET, responsible for uptaking dopamine, serotonin and noradreline respectively, and recycling them back for release. While the activity of each transporter is faithful to its neurotransmitter, NET has been shown to clear dopamine in DAT deprived or low DAT regions such as the brain cortex. DAT, SERT and NET are members of the +/Cl dependent membrane transporter family which also includes other members. These transporters consist of 12 transmembrane domains and intracellular N- and C-termini. NET also has a significant extracellular loop between transmembrane regions three and four, which contains various glycosylation sites. Like its counterparts, NETâ??s intracellular N- and C-termil domains are also subject to phosphorylation and protein-protein interactions important for modulating its activity and localization. In addition altertive splicing has also been shown to regulate NETâ??s expression and function. NET is specifically expressed on noradreline nerve termils, and is also expressed in the periphery, such as adrel glands and placenta. NET malfunction is largely associated with attention and mood, as well as various cardiovascular disorders. NET is also a target for psychostimulants such as cocaine and amphetamines which disrupt its function, thereby causing an increase of noradreline in syptic clefts.

General readings

Holton, et al., Nature Neuroscience (2005) 8(7):881-888.
Mash, et al., J. Neuroscience Methods (2005) 143(1):79-85.
Mao, et al., Am J Physiol Heart Circ Physiol (2004) 288(5):H2381-H2389.
Hahn, et al., J. Neuroscience (2003) 23(11):4470-4478.
Sung, et al., J. Neuroscience (2003) 23(5):1697-1709.
Bauman, PA and Blakely, RD, Arch Biochem Biophys (2000) 404(1):80-91.
Zhu, et al., J. Neurochemistry (2002) 82(1):146-153.
Apparsundaram, et al., J. Pharmacol Exp Ther (2001) 299(2):666-677.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Norepinephrine Transporter antibody

Human Heart; WB Suggested Anti-SLC6A2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human heart; SLC6A2 antibody - middle region (ARP41893_P050) in Human Heart cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Norepinephrine Transporter (N-term) antibody

Western blot of rat cortex homogenate showing specific immunolabeling of the ~ 55k norepinephrine transporter protein. Mouse IgG2b NET-05 Aff - Purified Bov, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Norepinephrine Transporter antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-Noradrenaline Transporter (NET) (extracellular) antibody, (1:400). 3, 4. Anti-Noradrenaline Transporter (NET) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Norepinephrine Transporter

Norepinephrine Transporter
0.25 mg / €250.00
  Acris Antibodies GmbH

Norepinephrine Transporter antibody

Norepinephrine Transporter Rabbit Aff - Purified Hu, Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Norepinephrine Transporter antibody

Norepinephrine Transporter Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Norepinephrine Transporter antibody

Norepinephrine Transporter Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Norepinephrine Transporter antibody

Western Blot: Noradrenaline transporter Antibody [NBP1-28665] - Western blot of rat cortex homogenate showing specific immunolabeling of the ~ 55k norepinephrine transporter protein. Mouse IgG Purified Ms, Rt WB
0.1 ml / €380.00
  Novus Biologicals Inc.

Norepinephrine Transporter antibody

Western Blot: Noradrenaline transporter Antibody [NBP1-60120] - This Anti-SLC6A2 antibody was used in Western Blot of Fetal Heart tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

9 Item(s)

per page
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