NOTCH2 antibody

Principal name

NOTCH2 antibody

Alternative names for NOTCH2 antibody

Notch 2, hN2, Neurogenic locus notch homolog protein 2

SwissProt ID

O35516 (Mouse), Q04721 (Human), Q9QW30 (Rat)

Gene ID

4853 (NOTCH2), 29492 (Notch2), 18129

Available reactivities

Can (Canine), Chimp (Chimpanzee), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Por (Porcine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat, Hamster

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F), Immunoprecipitation (IP)

Background of NOTCH2 antibody

NOTCH2 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch sigling network is an evolutiorily conserved intercellular sigling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular sigling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. NOTCH2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor for membrane bound ligands, and may play a role in vascular, rel and hepatic development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch sigling network is an evolutiorily conserved intercellular sigling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular sigling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, rel and hepatic development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Chen CD et al. Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J Neurochem 97:30-43 (2006). PubMed: 16515557
Search PubMed (MEDLINE) for references to Notch 2 intra 1. Rutenberg, J. B., Fischer, A., Jia, H., Gessler, M., Zhong, T. P., and Mercola, M. (2006) Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors, 133, 4381-4390.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOTCH2 antibody

Western blot analysis of extracts from 293 cells treated with TNF-a (20ng/ml, 30mins), using Notch 2 (cleaved-Asp1733) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 24hours), using NOTCH2 (Cleaved-Ala1734) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 24hours), using NOTCH2 (Cleaved-Val1697) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOTCH2 (N-term of NICD) antibody

anti-NOTCH 2 antibody was diluted 1:500 to detect NOTCH 2 in human liver tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. Rabbit IgG Serum Hu, Ms, Rt E, P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

NOTCH2 (Intra) antibody

WB using anti-Notch 2 (intra) antibody shows detection of a band at ~110 kDa corresponding to active Notch 2 protein (arrowhead). WB analysis was performed for Notch 2 expression using human mesothelial SV40 cells lysate obtained fromtransfected with a plasmid encoding a constitutively active Notch 2 (intra cellular Notch 2). Lanes 1-3 contain lysate 24 h (1), 48 h (2), and 72 h (3) post transfection. Lanes 4-6 are the corresponding control cells (untransfected). Anti-Notch 2 was used at 1:400. Rabbit Serum Can, Chimp, Hu, Ms, Rt E, P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

Predicted cell location: Cytoplasm. Positive control: Human brain tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using NOTCH2 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

Predicted band size: 266kDa. Positive control: Hela cell lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

WB Suggested Anti-NOTCH2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 721_B cell lysateThere is BioGPS gene expression data showing that NOTCH2 is expressed in 721_B Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

Western blot analysis of NOTCH2 (Cleaved-Ala1734) expression in Jurkat cells, treated with etoposide Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

Western blot analysis of Notch 2 (Cleaved-Asp1733) expression in293 cell extract treated with TNF-alpha Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOTCH2 antibody

NOTCH2 Rabbit IgG Serum Can, Hu, Mky, Ms, Rt E, WB
50 µl / €310.00
  Acris Antibodies GmbH

NOTCH2 (2396-2409) antibody

Formalin-Fixed Paraffin-Embedded Human Kidney stained with NOTCH2 antibody Cat.-No AP07611SU-N Rabbit Serum Can, Hu E, ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

NOTCH2 antibody

Figure 1. Staining NOTCH2 in Liver by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Supernatant Hu E, P
50 µl / €470.00
  Acris Antibodies GmbH

NOTCH2 control peptide

NOTCH2 Purified WB
50 µg / €190.00
  Acris Antibodies GmbH

NOTCH2 (2457-2471) antibody

Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with NOTCH2 antibody AP22760PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Bov, Can, Elephant, Hst, Hu, Mky, Ms, Por, Prim, Rb, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

NOTCH2 antibody

NOTCH2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

NOTCH2 antibody

NOTCH2 Goat Hu, Ms, Rt E
0.1 mg / €390.00
  Abnova Taiwan Corp.

NOTCH2 antibody

Immunohistochemical staining with NOTCH2 polyclonal antibody ( Cat # PAB10293 ) was diluted 1 : 500 to detect NOTCH 2 in human liver tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. Hu, Ms, Rt
0.2 ml / €560.00
  Abnova Taiwan Corp.

NOTCH2 antibody

Immunohistochemical staining with NOTCH2 polyclonal antibody ( Cat # PAB10294 ) was diluted 1 : 500 to detect NOTCH 2 in human kidney tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. Chimp, Hu, Ms, Rt
0.2 ml / €560.00
  Abnova Taiwan Corp.

NOTCH2 (cleaved) antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Notch 2 (Cleaved-Asp1733) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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