NOTCH4 antibody

Principal name

NOTCH4 antibody

Alternative names for NOTCH4 antibody

Notch 4, hNotch4, Neurogenic locus notch homolog protein 4

SwissProt ID

Q99466 (Human)

Gene ID

4855 (NOTCH4)

Available reactivities

Hu (Human), Por (Porcine), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of NOTCH4 antibody

NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch sigling network is an evolutiorily conserved intercellular sigling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, rel and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch sigling network is an evolutiorily conserved intercellular sigling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular sigling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, rel and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An altertive splice variant has been described but its biological ture has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Sugaya K., et al., (1997) Gene 189:235-244

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOTCH4 antibody

Predicted band size: 61kDa. Positive control: Human liver cancer and kidney tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: Human liver cancer tissue lysate Lane2: Human kidney tissue lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOTCH4 antibody

Predicted cell location: Cytoplasm. Positive control: Human tonsil and thyroid cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human tonsil tissue using NOTCH4 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOTCH4 antibody

WB Suggested Anti-NOTCH4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

NOTCH4 antibody

WB Suggested Anti-NOTCH4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NOTCH4 (cleaved) antibody

Western blot analysis of extracts from 293/COS7 cells, treated with etoposide 25uM 1h, using NOTCH4 (Cleaved-Val1432) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

NOTCH4 (cleaved) antibody

Western blot analysis of extracts from 293/COS7 cells, treated with etoposide 25uM 1h, using NOTCH4 (Cleaved-Val1432) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

NOTCH4 antibody

Human HepG2; WB Suggested Anti-NOTCH4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; NOTCH4 antibody - middle region (ARP32052_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu, Por WB
50 µg / €350.00
  AVIVA Systems Biology

NOTCH4 antibody

Human Breast; Immunohistochemistry with Human Breast tissue at an antibody concentration of 5.0ug/ml using anti-NOTCH4 antibody (ARP32726_P050); NOTCH4 antibody - middle region (ARP32726_P050) in Human Breast cells using Immunohistochemistry Rabbit IgG Aff - Purified Hu, Por P, WB
50 µg / €350.00
  AVIVA Systems Biology

NOTCH4 (C-term) antibody

NOTCH4 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

NOTCH4 antibody

NOTCH4 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

NOTCH4 antibody

NOTCH4 Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

NOTCH4 overexpression lysate

NOTCH4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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