Notum antibody

Principal name

Notum antibody

Alternative names for Notum antibody

SwissProt ID

Q6P988 (Human), Q8R116 (Mouse)

Gene ID

147111 (NOTUM), 77583 (Notum)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Notum antibody

Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the alpha/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Notum antibody

Western blot analysis of NOTUM in human kidney tissue lysate with NOTUM antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Notum antibody

Western blot of HepG2 cell lysate (11 µg/lane) using AP05257PU-N (10 µg/ml). Blots were developed with anti Rabbit HRP 1:100k and using Pierce Super Signal West
Femto. Rabbit IgG Purified Hu, Ms C, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Notum Control Peptide

Notum
50 µg / €160.00
  Acris Antibodies GmbH

Notum antibody

Notum Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Notum antibody

Western blot of HepG2 cell lysate (11 µg/lane) using Notum polyclonal antibody ( Cat # PAB10141 ) (10 µg/ml). Rabbit Hu, Ms C, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Notum antibody

Immunohistochemistry-Paraffin: NOTUM Antibody [NBP1-77060] - Human brain tissue with NOTUM antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Notum antibody

Immunohistochemistry-Paraffin: NOTUM Antibody [NBP1-86003] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells of tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Notum

Notum Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Notum

Notum Human
2 µg / €300.00
  Abnova Taiwan Corp.

Notum

Notum Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Notum

Notum Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

NOTUM overexpression lysate

NOTUM overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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