Notum antibody

Principal name

Notum antibody

Alternative names for Notum antibody

SwissProt ID

Q6P988 (Human), Q8R116 (Mouse)

Gene ID

147111 (NOTUM), 77583 (Notum)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Notum antibody

Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the alpha/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Notum antibody

  Rabbit Polyclonal NOTUM Antibody  
Western blot analysis of NOTUM in human kidney tissue lysate with NOTUM antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Notum antibody

Western blot of HepG2 cell lysate (11 µg/lane) using AP05257PU-N (10 µg/ml). Blots were developed with anti Rabbit HRP 1:100k and using Pierce Super Signal West
Femto. Rabbit IgG Purified Hu, Ms C, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NOTUM - human gene knockout kit via CRISPR

NOTUM - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NOTUM - human gene knockout kit via CRISPR

NOTUM - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOTUM - human gene knockout kit via CRISPR

NOTUM - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOTUM - human gene knockout kit via CRISPR

NOTUM - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Notum - mouse gene knockout kit via CRISPR

Notum - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Notum - mouse gene knockout kit via CRISPR

Notum - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Notum - mouse gene knockout kit via CRISPR

Notum - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Notum - mouse gene knockout kit via CRISPR

Notum - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Notum

  Recombinant protein of human notum pectinacetylesterase homolog (Drosophila) (NOTUM)  
Notum Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

NOTUM overexpression lysate

NOTUM overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NOTUM (mGFP-tagged) - Human notum pectinacetylesterase homolog (Drosophila) (NOTUM), 200 uL, >10^7 TU/mL

Lenti ORF particles, NOTUM (mGFP-tagged) - Human notum pectinacetylesterase homolog (Drosophila) (NOTUM), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NOTUM (Myc-DDK tagged) - Human notum pectinacetylesterase homolog (Drosophila) (NOTUM) , 200 uL, >10^7 TU/mL

Lenti ORF particles, NOTUM (Myc-DDK tagged) - Human notum pectinacetylesterase homolog (Drosophila) (NOTUM) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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