NOX4 antibody

Principal name

NOX4 antibody

Alternative names for NOX4 antibody

RENOX, NADPH oxidase 4, Kidney superoxide-producing NADPH oxidase, KOX-1, Renal NAD(P)H-oxidase

SwissProt ID

Q924V1 (Rat), Q9JHI8 (Mouse), Q9NPH5 (Human)

Gene ID

50507 (NOX4), 50490 (Nox4), 85431

Available reactivities

Bov (Bovine), Hu (Human), Mky (Monkey), Ms (Mouse), Rb (Rabbit), Rt (Rat), Sh (Sheep), Can (Canine), Por (Porcine), Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Flow Cytometry (F), Immunoprecipitation (IP)

Background of NOX4 antibody

NOX4 (DPH oxidase 4) is a constitutive DPH oxidase which complex with CYBA/p22phox for generating superoxide intracellularly and is found primarily in vascular cells, fibroblasts, osteoclasts and is abundantly expressed in the kidney. NOX4 regulates sigling cascades through phosphatases inhibition and function as oxygen sensor regulating the KCNK3/TASK-1 potassium channel as well as HIF1 alpha activity. NOX4 has also been implicated in regulation of insulin sigling cascade, apoptosis, bone resorption and LPS-mediated activation of NFkB. In vascular smooth muscle cells, NOX4 is positively regulated by Poldip2 which is a Nox4/p22phox interacting protein and Nox4/p22phox-Poldip2 complex regulates Rho-dependent cytoskeletal reorganization as well as cellular migration. TGF- beta is another positive regulator of Nox4 which is important in vascular fibrosis and differentiation. Unlike Nox1/Nox2, Nox4 is constitutively active, producing primarily H2O2 rather thanO2 and this difference in the species generated underlie NOX-specific actions in cell sigling. Nox4 contributes to basal ROS production through its constitutive activity and to increased ROS generation when stimulated by Ang II, glucose, TNF alpha and growth factors. NOX4 has been implicated in hypertension, atherosclerosis, and cardiovascular and rel complications of diabetes and in remodeling of pulmory arteries in hypertension.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOX4 antibody

Western Blot: NOX4 Antibody [TA336529] - Detection of NOX4 in human kidney lysates using TA336529 at 2.0 ug/ml. A non-specific band is often observed running at 50 kDa in tissue lysates which is believed to correspond to the human IgG heavy chain. Rabbit Purified Bov, Hu, Ms, Por, Prim, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

Predicted band size: 67 kDa . Positive control: Human kidney tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

Predicted cell location: Cytoplasm, Nucleus. Positive control: Human gastric cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using NOX4 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

NOX4 Antibody (N-term) (Cat. #TA324531) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NOX4 antibody detected the NOX4 protein (arrow). Rabbit IgG Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

Western blot analysis of extracts of various cell lines, using NOX4 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

Western blot analysis of NOX4 in Jurkat cell lysate with NOX4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

NOX4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

NOX4 antibody

NOX4 Rabbit Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

NOX4 antibody

Western blot analysis of NOX4 in human kidney lysates with NOX4 polyclonal antibody at 2.0 µg/ml ( Cat# PAB12095 ). A non-specific band is often observed running at 50 kDa in tissue lysates which is believed to correspond to the human IgG heavy chain. Rabbit Bov, Hu, Ms, Rt, Sh C, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

NOX4 antibody

NOX4 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

NOX4 antibody

Western blot analysis of NOX4 expression in JAR (A); Jurkat (B); SP2/0 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

NOX4 antibody

Western blot analysis of NOX4 expression in JAR (A); Jurkat (B); SP2/0 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

NOX4 antibody

Western blot analysis of NOX4 expression in JAR (A); Jurkat (B); SP2/0 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

NOX4 antibody

Detection of NOX4 in human kidney lysates using NB110-58849 at 2.0 ug/ml. A non-specific band is often observed running at 50 kDa in tissue lysates which is believed to correspond to the human IgG heavy chain. Rabbit Biotin Bov, Hu, Mky, Ms, Rt, Sh P, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

NOX4 antibody

NOX4 Rabbit DyLight488 Bov, Hu, Mky, Ms, Rt, Sh P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

NOX4 antibody

Detection of NOX4 in proximal convoluted tubules of the kidney using NB110-58849 at 5ug/ml. Rabbit HRP Bov, Hu, Mky, Ms, Rt, Sh WB
0.1 ml / €380.00
  Novus Biologicals Inc.

NOX4 Control Peptide

NOX4
50 µg / €140.00
  Novus Biologicals Inc.

NOX4 antibody

NOX4 Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rb, Rt, Sh ICC/IF, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NOX4

NOX4 Human
2 µg / €300.00
  Abnova Taiwan Corp.

NOX4

NOX4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

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