NOX4 antibody

Principal name

NOX4 antibody

Alternative names for NOX4 antibody

RENOX, NADPH oxidase 4, Kidney superoxide-producing NADPH oxidase, KOX-1, Renal NAD(P)H-oxidase

SwissProt ID

Q924V1 (Rat), Q9JHI8 (Mouse), Q9NPH5 (Human)

Gene ID

50507 (NOX4), 50490 (Nox4), 85431

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Sh (Sheep), Por (Porcine), Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of NOX4 antibody

NOX4 (DPH oxidase 4) is a constitutive DPH oxidase which complex with CYBA/p22phox for generating superoxide intracellularly and is found primarily in vascular cells, fibroblasts, osteoclasts and is abundantly expressed in the kidney. NOX4 regulates sigling cascades through phosphatases inhibition and function as oxygen sensor regulating the KCNK3/TASK-1 potassium channel as well as HIF1 alpha activity. NOX4 has also been implicated in regulation of insulin sigling cascade, apoptosis, bone resorption and LPS-mediated activation of NFkB. In vascular smooth muscle cells, NOX4 is positively regulated by Poldip2 which is a Nox4/p22phox interacting protein and Nox4/p22phox-Poldip2 complex regulates Rho-dependent cytoskeletal reorganization as well as cellular migration. TGF- beta is another positive regulator of Nox4 which is important in vascular fibrosis and differentiation. Unlike Nox1/Nox2, Nox4 is constitutively active, producing primarily H2O2 rather thanO2 and this difference in the species generated underlie NOX-specific actions in cell sigling. Nox4 contributes to basal ROS production through its constitutive activity and to increased ROS generation when stimulated by Ang II, glucose, TNF alpha and growth factors. NOX4 has been implicated in hypertension, atherosclerosis, and cardiovascular and rel complications of diabetes and in remodeling of pulmory arteries in hypertension.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOX4 antibody

  Anti-NOX4 Rabbit Polyclonal Antibody  
Predicted band size: 67 kDa . Positive control: Human kidney tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

  Anti-NOX4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human gastric cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using NOX4 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

  Rabbit polyclonal NOX4 Antibody (N-term)  
NOX4 Antibody (N-term) (Cat. #TA324531) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NOX4 antibody detected the NOX4 protein (arrow). Rabbit IgG Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

  Rabbit anti-NOX4 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using NOX4 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOX4 antibody

  Rabbit Polyclonal Anti-NOX4 Antibody  
Western blot analysis of NOX4 in Jurkat cell lysate with NOX4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

NOX4 - human gene knockout kit via CRISPR

NOX4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NOX4 - human gene knockout kit via CRISPR

NOX4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOX4 - human gene knockout kit via CRISPR

NOX4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOX4 - human gene knockout kit via CRISPR

NOX4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nox4 - mouse gene knockout kit via CRISPR

Nox4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nox4 - mouse gene knockout kit via CRISPR

Nox4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nox4 - mouse gene knockout kit via CRISPR

Nox4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nox4 - mouse gene knockout kit via CRISPR

Nox4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NOX4 overexpression lysate

NOX4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NOX4 (mGFP-tagged) - Human NADPH oxidase 4 (NOX4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, NOX4 (mGFP-tagged) - Human NADPH oxidase 4 (NOX4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NOX4 (mGFP-tagged)-Human NADPH oxidase 4 (NOX4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NOX4 (mGFP-tagged)-Human NADPH oxidase 4 (NOX4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, NOX4 (Myc-DDK tagged) - Human NADPH oxidase 4 (NOX4), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, NOX4 (Myc-DDK tagged) - Human NADPH oxidase 4 (NOX4), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, NOX4 (Myc-DDK-tagged)-Human NADPH oxidase 4 (NOX4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, NOX4 (Myc-DDK-tagged)-Human NADPH oxidase 4 (NOX4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Nox4 (GFP-tagged) - Mouse NADPH oxidase 4 (Nox4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nox4 (GFP-tagged) - Mouse NADPH oxidase 4 (Nox4), 200 uL, >10^7 TU/mL  
200 µl / €1,220.00
  OriGene Technologies, Inc.

Lenti ORF particles, Nox4 (Myc-DDK-tagged) - Mouse NADPH oxidase 4 (Nox4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Nox4 (Myc-DDK-tagged) - Mouse NADPH oxidase 4 (Nox4), 200 uL, >10^7 TU/mL  
200 µl / €1,090.00
  OriGene Technologies, Inc.

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