NOXA antibody

Principal name

NOXA antibody

Alternative names for NOXA antibody

PMAIP1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1

SwissProt ID

Q13794 (Human), Q5U777 (Rat), Q9JM54 (Mouse)

Gene ID

5366 (PMAIP1), 58801 (Pmaip1), 492821

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of NOXA antibody

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified , which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9 . Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53 (1-3). Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development (4).

General readings

Bai Y, Ahmad U, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennett CF, Bothwell AL, Pober JS, Tellides G.
Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.
J Biol Chem. 2008 Mar 14;283(11):6832-42. Epub 2008 Jan 11.
PMID: 18192275

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOXA antibody

  Rabbit Polyclonal Noxa Antibody  
Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

  Goat Anti-PMAIP1 / NOXA Antibody  
(0.03ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

  Rabbit polyclonal anti-Noxa antibody  
Western blot analysis of Noxa expression in Jurkat cell lysate. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

  Rabbit Polyclonal Noxa Antibody  
Western Blot: Noxa Antibody [TA336343] - Noxa expression was stably reduced in HCT116 cells by shRNA. Image from verified customer review. Rabbit Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

  Mouse Monoclonal Noxa Antibody (114C307.1)  
Western Blot: Noxa Antibody (114C307.1) [TA336673] - detection of Noxa antibody in A) 293 cells transfected with human Noxa, B) RL-7 cell (a follicular lymphoma) and C) T98G lysate using this antibody. Mouse IgG1 114C307.1 Purified Hu, Ms C, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

Formalin fixed, paraffin embedded human stomach stained with Rabbit anti human NOXA (AP05558PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NOXA antibody

Formalin fixed, paraffin embedded human stomach stained with Rabbit anti human NOXA (AP05558PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €300.00
  Acris Antibodies GmbH

NOXA antibody

Immunohistochemistry staining of human brain / cortex (Formalin-fixed, Paraffin-embedded tissue after heat-induced antigen retrieval) using NOXA antibody Cat.-No. AP07195PU-N (concentration 10 ug/ml). Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

NOXA antibody

AP07509PU-N NOXA antibody staining of Formalin-Fixed Paraffin-Embedded Huuman Pancreas at 5 ug/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PMAIP1 - human gene knockout kit via CRISPR

PMAIP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PMAIP1 - human gene knockout kit via CRISPR

PMAIP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PMAIP1 - human gene knockout kit via CRISPR

PMAIP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pmaip1 - mouse gene knockout kit via CRISPR

Pmaip1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pmaip1 - mouse gene knockout kit via CRISPR

Pmaip1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pmaip1 - mouse gene knockout kit via CRISPR

Pmaip1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pmaip1 - mouse gene knockout kit via CRISPR

Pmaip1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NOXA

  Recombinant protein of human phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)  
NOXA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PMAIP1 overexpression lysate

PMAIP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PMAIP1 (mGFP-tagged) - Human phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1), 200 uL, >10^7 TU/mL

Lenti ORF particles, PMAIP1 (mGFP-tagged) - Human phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, PMAIP1 (Myc-DDK tagged) - Human phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PMAIP1 (Myc-DDK tagged) - Human phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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