NOXA antibody

Principal name

NOXA antibody

Alternative names for NOXA antibody

PMAIP1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1

SwissProt ID

Q13794 (Human), Q5U777 (Rat), Q9JM54 (Mouse)

Gene ID

5366 (PMAIP1), 58801 (Pmaip1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP), Frozen Sections (C)

Background of NOXA antibody

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

General readings

Bai Y, Ahmad U, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennett CF, Bothwell AL, Pober JS, Tellides G.
Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.
J Biol Chem. 2008 Mar 14;283(11):6832-42. Epub 2008 Jan 11.
PMID: 18192275

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NOXA antibody

Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

(0.03ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

Western blot analysis of Noxa expression in Jurkat cell lysate. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

Western Blot: Noxa Antibody [TA336343] - Noxa expression was stably reduced in HCT116 cells by shRNA. Image from verified customer review. Rabbit Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA antibody

Western Blot: Noxa Antibody (114C307.1) [TA336673] - detection of Noxa antibody in A) 293 cells transfected with human Noxa, B) RL-7 cell (a follicular lymphoma) and C) T98G lysate using this antibody. Mouse IgG1 114C307.1 Purified Hu, Ms C, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NOXA Control Peptide

NOXA Purified
50 µg / €190.00
  Acris Antibodies GmbH

NOXA antibody

Formalin fixed, paraffin embedded human stomach stained with Rabbit anti human NOXA (AP05558PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NOXA antibody

Formalin fixed, paraffin embedded human stomach stained with Rabbit anti human NOXA (AP05558PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €300.00
  Acris Antibodies GmbH

NOXA antibody

Immunohistochemistry staining of human brain / cortex (Formalin-fixed, Paraffin-embedded tissue after heat-induced antigen retrieval) using NOXA antibody Cat.-No. AP07195PU-N (concentration 10 ug/ml). Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

NOXA antibody

AP07509PU-N NOXA antibody staining of Formalin-Fixed Paraffin-Embedded Huuman Pancreas at 5 ug/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

NOXA Control Peptide

NOXA
50 µg / €160.00
  Acris Antibodies GmbH

NOXA antibody

NOXA Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

NOXA antibody

NOXA Mouse Hu WB
50 µl / €370.00
  Abnova Taiwan Corp.

NOXA antibody

NOXA Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

NOXA antibody

Western blot detection of PMAIP1 in RL-7 cell ( a follicular lymphoma ) lysate. A protein of approximate molecular weight of 11 kDa is detected. Using PMAIP1 monoclonal antibody, clone 114C307.1 ( Cat # MAB0093 ) at 2 µg/ml. Mouse IgG1 114C307.1 Purified Hu ICC/IF, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

NOXA antibody

Western blot analysis of Pmaip1 in A ) human, B ) mouse, and C ) rat thymus tissue using Pmaip1 polyclonal antibody ( Cat # PAB0201 ) at 2 µg/ml. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

NOXA antibody

NOXA Rabbit Ms WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

NOXA antibody

NOXA Rabbit Ms WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

NOXA antibody

Western blot analysis of PMAIP1 expression in Jurkat cell lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

NOXA antibody

Immunohistochemistry of Pmaip1 in human stomach tissue with Pmaip1 polyclonal antibody ( Cat # PAB12863 ) at 1 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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